Research Facility : Translational Research Facility

A pre-product development facility for healthcare solutions at THSTI

 

Mission

TRF Biofoundry creates a sustained pipeline of pre-clinical Leads from the high quality research outcome of THSTI and other BRIC institutions, Startups/ SMEs, providing a go to place for the Industry to steer such Leads for their potential clinical development.

Vision

Academia - industry collaboration to propel development of affordable, accessible health solutions promoting bio-innovation and bio-manufacturing for the country.

Goal

Biofoundry with state of art facilities, creating globally competent high quality innovative product leads and processes for industry to develop Vaccines, Monoclonal Antibodies, Live Biotherapeutics and Diagnostics. 

  • Develop a pipeline of industry relevant leads for healthcare solutions relevant for India, LMIC and global pandemic preparedness
  • Develop an interface for knowledge generation and sharing, training of human resource with high end skills
  • Promote bio-entrepreneurship, scaling up of Startups and SMEs by providing common access pilot to pre-product development facilities.

 

Expertise Area

 

Center for Excellence in Innovation and Development of Monoclonal Antibodies

  • Development of  high-quality monoclonal antibody
  • Monoclonal and polyclonal antibody production and purification services at a custom-made level
  • Cell line development

Live Biotherapeutics Development Unit

  • Indigenous microbial consortia as live biotherapeutics
  • Genetically modified probiotics as live biotherapeutics
  • Service for genome engineering

Vaccine Design and Development Laboratory

  • Designing of new generation sub-unit vaccine candidates
  • Advanced solutions for upstream & downstream processing with integrated regulatory expertise
  • in-depth Drug Substance Analysis

GMPure Center for Vaccine & Biologics

  • Production and characterization of recombinant protein and GMP-compliant cellbanks
  • Pre-clinical batches drug substance production

IVD Manufacturing Support Facility

  • Development of innovative in vitro diagnostic assays
  • Diagnostic solutions for rapid pathogen identification and antimicrobial susceptibility testing
  • Prototyping and feasibility studies

DMMP Centre for Therapeutic Development

  • Drug Metabolism and Pharmacokinetics (DMPK} services, applying state-of-the-art techniques
  • Tox studies
  • In-vitro ADME studies
  • Pre-clinical model development and In-vivo PK studie

 

Contact Details

Dr. Soma Patnaik
 soma@thsti.res.in
 0129- 2876299