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DR. YASHWANT KUMAR, Ph.D.  

Research Scientist
+91-129-2876496 
y.kumar [at] thsti [dot] res [dot] in
Postdoc, Weizmann Institute of Science, Israel.
PhD, National Chemical Laboratory, India.
M.Sc., University of Pune.


Metabolomics research has benefited significant fractions of research investigation focused on understanding, diagnosing and preventing human disease. Large number of potential biomarker has been discovered using metabolomics and many of them has been tested for translational applications.  Our research focus on discovery of new biomarker in disease condition using metabolomics, multivariate data analysis and machine learning approaches. This approach can be step forward in disease diagnostics, future prediction and prognosis for any disease condition. At present, using high-resolution mass spectrometer with tandem (MS/MS) and sequential MS/MS (MSn) capability we are trying to measure the whole set of metabolites and lipids in a diabetic condition. We work on complete pipeline from experiment design, sample preparation, analysis, data processing and bioinformatics. Additionally, we are also working on determine the structure of metabolic pathway and flux in diseased condition using stable isotope.

1. Dar, M. S., Kumar, Y., Punekar, S. A., Gupta, V. S., Dholakia, B. B., & Giri, A. P. (2020). Comparative non-targeted metabolomics reveals differentiation of biochemical pathway network among fruits of natural populations and Cv. Alphonso of mango (Mangifera indica L.). Journal of Proteins and Proteomics. https://doi.org/10.1007/s42485-020-00047-6

2.  Chaudhary, D., Marzuki, M., Lee A., Bouzeyen R., Singh A., Gosain T.P., Kidwai, S., Grady C., Tsotetsi K., Chawla K., Shihui F., Lum J., Gupta S. K., Agarwal N., Tsenova L.,Kumar Y., Lee B., Kumar P., Thakur K. G., Singh R., Singhal A.,  Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response. bioRxiv 2020.09.01.277368; doi: https://doi.org/10.1101/2020.09.01.277368 [preprint]

3. Pant, A., Bag, S., Saha, B., Verma, J., Kumar, P., Banerjee, S., Kumar, B., Kumar, Y., Desigamani, A., Maiti, S., Maiti, T. K., Banerjee, S. K., Bhadra, R. K., Koley, H., Dutta, S., Nair, G. B., Ramamurthy, T., & Das, B. (2020). Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae . Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006283117

4. Kumar, A., Kumar, Y., Sevak, J. K., Kumar, S., Kumar, N., & Gopinath, S. D. (2020). Metabolomic analysis of primary human skeletal muscle cells during myogenic progression. Scientific Reports. https://doi.org/10.1038/s41598-020-68796-4

5. Mohammed, S. A., Paramesha, B., Kumar, Y., Tariq, U., Arava, S. K., & Banerjee, S. K. (2020).Allylmethylsulfide, a Sulfur Compound Derived from Garlic, Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2020/7856318

6. Jadhav, U., Mundhe, S., Kumar, Y., Jogaiah, S., Upadhyay, A., Gupta, V. S., & Kadoo, N. Y. (2020). Gibberellic Acid Induces Unique Molecular Responses in ‘Thompson Seedless’ Grapes as Revealed by Non-targeted Metabolomics. Journal of Plant Growth Regulation. https://doi.org/10.1007/s00344-020-10102-7

7. Kumari, S., Katare, P. B., Elancheran, R., Nizami, H. L., Paramesha, B., Arava, S., Sarma, P. P., Kumar, R., Mahajan, D., Kumar, Y., Devi, R., & Banerjee, S. K. (2020). Musa balbisiana Fruit Rich in Polyphenols Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats via Inhibition of Inflammation and Oxidative Stress. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/7147498

8. Nizami, H. L., Katare, P., Prabhakar, P., Kumar, Y., Arava, S. K., Chakraborty, P., Maulik, S. K., & Banerjee, S. K. (2019). Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing Myocardial Insulin Resistance. Molecular Nutrition and Food Research, 63(17). https://doi.org/10.1002/mnfr.201900109

9. Choudhary, E., Sharma, R., Kumar, Y., & Agarwal, N. (2019). Conditional silencing by CRISPRi reveals the role of DNA gyrase in formation of drug-tolerant persister population in Mycobacterium tuberculosis. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2019.00070

10. Lomate, P. R., Dewangan, V., Mahajan, N. S., Kumar, Y., Kulkarni, A., Wang, L., Saxena, S., Gupta, V. S., & Giri, A. P. (2018). Integrated transcriptomic and proteomic analyses suggest the participation of endogenous protease inhibitors in the regulation of protease gene expression in helicoverpa armigera. Molecular and Cellular Proteomics. https://doi.org/10.1074/mcp.RA117.000533

11. Kumar, V., Rana, A., Lal Meena, C., Sharma, N., Kumar, Y., & Mahajan, D. (2018). Electrophilic Activation of Carboxylic Anhydrides for Nucleophilic Acylation Reactions. Synthesis (Germany)50(19). https://doi.org/10.1055/s-0037-1609564

12. Kumar, Y., Zhang, L., Panigrahi, P., Dholakia, B. B., Dewangan, V., Chavan, S. G., Kunjir, S. M., Wu, X., Li, N., Rajmohanan, P. R., Kadoo, N. Y., Giri, A. P., Tang, H., & Gupta, V. S. (2016). Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics. Plant Biotechnology Journalhttps://doi.org/10.1111/pbi.12522

13.Kumar, Y., Dholakia, B. B., Panigrahi, P., Kadoo, N. Y., Giri, A. P., & Gupta, V. S. (2015). Metabolic profiling of chickpea-Fusarium interaction identifies differential modulation of disease resistance pathways. Phytochemistry. https://doi.org/10.1016/j.phytochem.2015.04.001

  1. Method of predict diabetes outcome susceptibility (201711041969).
  2. Method of preparing nutraceutical and pharmaceutical products based on Musa balbisiana and uses thereof (201911015320)
  3. A Herbal extract for treatment of obesity and related hyperglycemia and a method for its extraction (201831046382A)
  1. To identify unique differential signatures for the diagnosis of stage-specific Non-alcoholic fatty liver disease using the multi-omics approach: A pilot study. (Co-Principal Investigator)
  2. Metabolic profiling as per glycemic status [normoglycemia/prediabetes/diabetes] in women with a history of Gestational diabetes mellitus (GDM)-A cross-sectional study. (Co-Principal Investigator)
  3. Preclinical Evaluations of Select AYUSH Herbal Extracts / Formulations for Mitigating SARS- CoV2 and Associated Pathologies (Co-Principal Investigator)
  4. Multi-Omics Signatures of Human Placenta: Real time assessment of underlying mechanisms for prediction of birth outcomes and development (Co-Principal Investigator)
  5. Metabolite profiling in pregnant mothers: identification of signature metabolites in pregnancies leading to preterm birth. (Co-Principal Investigator)

 

1. Sonu Kumar Gupta

2. Taruna