M.Sc., M.Tech., Ph.D.
- 2017: JSPS Fellow, Osaka University, Japan
- 2008-2011: CNRS Fellow, The Institute of Integrative Biology of the Cell, France
- 2006-2008: CSIR Research Fellow, Indian Institute of Chemical Biology, India
- 2003-2006: ICMR Research Fellow, Indian Institute of Chemical Biology, India
- 2001-2003: M.Tech., Biotech. & Biochem. Eng., IIT-Kharagpur, India
Currently, my lab is working to understand the genome and genetics of microbial community associated with (a) Gastroenteritis (b) Sepsis (c) Term and preterm birth.
(a) Genomics of bacterial pathogens: We are investigating the (i) genome compositions and functions of bacterial pathogens associated with SEPSIS, DIARRHOEA and GASTRIC CANCER (ii) Emergence of antimicrobial resistant bacterial pathogens. In addition, our lab is actively involved in engineering bacterial genome for developing reporter strains to screen compound library and identify hit molecules that will help to restore the efficacy of existing antibiotics against drug resistant bacterial pathogens, specially Gram-negative ESKAPE pathogens.
Vision: Identify potential target and hit molecules for developing antibiotic potentiators.
(b) Reproductive tract microbiome: We are decoding the metagenomics sequences Indian women enrolled in the GARBH-Ini pregnancy cohort. Our major focus is oriented to understand the (i) role of vaginal microbiota in the birth outcomes (ii) specific microbial genomic signatures associated with birth outcomes. We have isolated different Lactobacillus species from the vaginal milieu of Indian women. Currently, decoding their genome sequences and looking for functions associated with inflammation, anti-inflammation, antimicrobial and antimicrobial resistance.
Vision: Understand the biology of preterm birth (PTB) and role of vaginal microbiota in PTB.
73. Biswas Q, Purohit A, Kumar A, Rakshit D, Maiti D, Das B, Bhadra RK, (2022) Genetic and mutational analysis of virulence traits and its modulation in an environmental toxigenic Vibrio cholerae non-O1/non-O139 strain VCE232. Microbiology, SGM (UK). doi: 10.1099/mic.0.001135 (Corresponding author)
72. Yadav YK, Banerjee SK, Das B, Chaudhary K (2022) Editorial: System biology and Omics approaches for understanding complex disease biology. Front. Genet. doi: 10.3389/fgene.2022.896818
71. Medigeshi M., Batra G, Murugesan D.R., Thiruvengadam R., Chattopadhyay S., Das B., Gosain M., Ayushi, Singh J., Anbalagan A., Shaman H., Pargai K., Mehdi F., Das S.J., Kahlon N., Singh S., Kshetrapal P., Wadhwa N., Pandey A.K., Bhatnagar S., Garg P.K. (2022) Sub-optimal Neutralisation of Omicron (B.1.1.529) Variant by Antibodies induced by Vaccine alone or SARS-CoV-2 Infection plus Vaccine (Hybrid Immunity) post 6-months. eBioMedicine doi.org/10.1101/2022.01.04.22268747
70. Bir R, Gautam H, Arif N, Verma J., Banerjee S, Tyagi S, Mohapatra S, Sood S, Dhawan B, Chaudhry R, Kapil A, Das BK, Das B (2022) Analysis of Colistin resistance in Carbapenem-Resistant Enterobacterales and XDR Klebsiella pneumoniae. Therapeutic Advances in Infectious Disease. doi:10.1177/20499361221080650
69. Aggarwal H, Pathak P, Singh V, Kumar Y, Shankar M, Das B, Jagavelu K, Dikshit M (2021) Vancomycin-induced modulation of Gram-positive gut bacteria and metabolites remediate insulin resistance in iNOS knockout mice. Front Cell Infect Microbiol. 19 January 2022DOI:10.21203/rs.3.rs-826534/v1
68. MehrotraT, Devi TB, Kumar S, Talukdar D, Karmakar SP, Kothidar A, Verma J, Kumari S, Alexander SM, Retnakumar RJ, Devadas K, Ray A, Mutreja A, Nair GB, Chattopadhyay S, Das B (2021) Antimicrobial resistance and virulence in Helicobacter pylori: Genomic insights. Genomics.2021 Oct 5;113(6):3951-3966(Corresponding Author)
67. KumarS,KumariN, Talukdar D, Kothidar A, Sarkar M, Mehta O, Kshetrapal P, Wadhwa N, Thiruvengadam R, Desiraju BK, GARBH-Ini study group, Nair GB, Bhatnagar S, Mukherjee S, Das B, (2021)The Vaginal Microbial Signatures of Preterm Birth Delivery in Indian Women.Front Cell Infect Microbiol.2021 April,doi: 10.3389/fcimb.2021.622474 (Corresponding Author)
66. Pinna NK, Anjana RM, Saxena S, Dutta A, Gnanaprakash V, Rameshkumar G, Aswath S, Raghavan S, Rani CSS, Radha V, Balasubramanyam M, Pant A, Nielsen T, Jørgensen T, Færch K, Kashani A, Silva MCA, Vestergaard H, Hansen TH, Hansen T, Arumugam M, Nair GB, Das B., Pedersen O, Mohan V, Mande SS. Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark. Genome Med. 2021 Mar 3;13(1):36. doi: 10.1186/s13073-021-00851-9. PMID: 33658065; PMCID: PMC7931552. (Corresponding Author)
65. Das B, Dutta S, Ghosh TS, Kumar S, Kushal RK, Ray P, Suri, V, Nair GB (2021) Human milk microbiome of healthy lactating North Indian mothers is dominated by genus Pseudomonas. Journal of Human Lactation. 2021 Sep 28:8903344211048415.PMID: 34581614
64. Chowdhury G, Senapati T, Das B, Kamath A, Pal D, Bose P, Deb A, Paul S, Mukhopadhyay AK, Dutta S, Ramamurthy T (2021) Laboratory evaluation of the rapid diagnostic tests for the detection of Vibrio cholerae O1 using diarrheal samples. 2021 May, PLOS Neg. Trop. Dis. 2021 Jun 15;15(6):e0009521. doi: 10.1371/journal.pntd.0009521. PMID: 34129602.
63. Kumar M, Kumar J, Sharma S, Hussain A, Shelly A, Das B, Mazumder S (2021) TLR22-mediated activation of TNF--caspase-1/IL-1 inflammatory axis leads to apoptosis of Aeromonas hydrophila-infected macrophages. Molecular Immunology. S0161-5890(21)00206-6
62. Alvarez-Silva C, Kashani A, Hansen TH, Pinna NK, Anjana RM, Dutta A, Saxena S, Støy J, Kampmann U, Nielsen T, Jørgensen T, Gnanaprakash V, Gnanavadivel R, Sukumaran A, Rani CSS, Færch K, Radha V, Balasubramanyam M, Nair GB, Das B. Vestergaard H, Hansen T, Mande SS, Mohan V, Arumugam M, Pedersen O. Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India. Genome Med. 2021 Mar 3;13(1):37. doi: 10.1186/s13073-021-00856-4. PMID: 33658058; PMCID: PMC7931542.
61. Will RC, Ramamurthy T, Sharma NC, Veeraraghavan B, Sangal L, Haldar P, Pragasam AK, Vasudevan K, Kumar D, Das B. Heinz E, Melnikov V, Baker S, Sangal V, Dougan G, Mutreja A. Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae. Nat. Commun. 2021 Mar 8;12(1):1500. doi: 10.1038/s41467-021-21870-5. PMID: 33686077; PMCID: PMC7940655.
60. Devi TB, Devadas K, George M, Gandhimathi A, Chouhan D, Retnakumar RJ, Alexander SM, Varghese J, Dharmaseelan S, Chandrika SK, Jissa VT, Das B.Nair GB, Chattopadhyay S. Low Bifidobacterium Abundance in the Lower Gut Microbiota Is Associated With Helicobacter pylori-Related Gastric Ulcer and Gastric Cancer. Front Microbiol. 2021 Feb 26;12:631140. doi: 10.3389/fmicb.2021.631140. PMID: 33717022; PMCID: PMC7953064.
59. Pant A, Bag S, Saha B, Verma J, Kumar P, Banerjee S, Kumar B, Kumar Y, Desigamani A, Maiti S, Maiti TK, Banerjee SK, Bhadra RK, Koley H, Dutta S, Nair GB, Ramamurthy T, Das B. Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23762-23773. doi: 10.1073/pnas.2006283117. Epub 2020 Sep 1. PMID: 32873641; PMCID: PMC7519391.(Corresponding author)
58. Das B.Bhadra RK. (p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens. Front Microbiol. 2020 Oct 9;11:563944. doi: 10.3389/fmicb.2020.563944. PMID: 33162948; PMCID: PMC7581866.(Corresponding author)
57. Rakshit D, Dasgupta S, Das B, Bhadra RK. Functional Insights Into the Role of gppA in (p)ppGpp Metabolism of Vibrio cholerae. Front Microbiol. 2020 Sep 29;11:564644. doi: 10.3389/fmicb.2020.564644. PMID: 33117311; PMCID: PMC7552824.(Corresponding author)
56. Kumar A, Das B., Kumar N. Vibrio Pathogenicity Island-1: The Master Determinant of Cholera Pathogenesis. Front Cell Infect Microbiol. 2020 Oct 6;10:561296. doi: 10.3389/fcimb.2020.561296. PMID: 33123494; PMCID: PMC7574455.(Corresponding author)
55. Kedia S, Ghosh TS, Jain S, Desigamani A, Kumar A, Gupta V, Bopanna S, Yadav DP, Goyal S, Makharia G, Travis SPL, Das B. Ahuja V. Gut microbiome diversity in acute severe colitis is distinct from mild to moderate ulcerative colitis. J. Gastroenterol Hepatol. 2021 Mar;36(3):731-739. doi: 10.1111/jgh.15232. Epub 2020 Sep 14. PMID: 32870508.(Corresponding author)
54. Mehta O, Ghosh TS, Kothidar A, Gowtham MR, Mitra R, Kshetrapal P, Wadhwa N, Thiruvengadam R; GARBH-Ini study group, Nair GB, Bhatnagar S, Das B. Vaginal Microbiome of Pregnant Indian Women: Insights into the Genome of Dominant Lactobacillus Species. Microb Ecol. 2020 Aug;80(2):487-499. doi: 10.1007/s00248-020-01501-0. Epub 2020 Mar 23. PMID: 32206831.(Corresponding author)
53. Chatterjee P, Nagi N, Agarwal A, Das B, Banerjee S, Sarkar S, Gupta N, Gangakhedkar RR. The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence. Indian J Med Res. 2020 Feb & Mar;151(2 & 3):147-159. doi: 10.4103/ijmr.IJMR_519_20. PMID: 32362642; PMCID: PMC7357405.
52. Das B.Insights into TLCΦ lysogeny: A twist in the mechanism of IMEX integration. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18159-18161. doi: 10.1073/pnas.1912633116. Epub 2019 Aug 22. PMID: 31439815; PMCID: PMC6744843.(Corresponding author)
51. Das B.Chattoraj DK. Commentary: Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome. Front Microbiol. 2019 Jun 19;10:1314. doi: 10.3389/fmicb.2019.01314. PMID: 31275259; PMCID: PMC6594386.
50. Ramamurthy T, Mutreja A, Weill FX, Das B. Ghosh A, Nair GB. Revisiting the Global Epidemiology of Cholera in Conjunction With the Genomics of Vibrio cholerae. Front Public Health. 2019 Jul 23;7:203. doi: 10.3389/fpubh.2019.00203. Erratum in: Front Public Health. 2019 Aug 23;7:237. PMID: 31396501; PMCID: PMC6664003.
49. Pareek S, Kurakawa T, Das B, Motooka D, Nakaya S, Rongsen-Chandola T, Goyal N, Kayama H, Dodd D, Okumura R, Maeda Y, Fujimoto K, Nii T, Ogawa T, Iida T, Bhandari N, Kida T, Nakamura S, Nair GB, Takeda K. Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi. NPJ Biofilms Microbiomes. 2019 Dec 20;5(1):37. doi: 10.1038/s41522-019-0110-9. PMID: 31885873; PMCID: PMC6925221.
48. Das B,Verma J, Kumar P, Ghosh A, Ramamurthy T. Antibiotic resistance in Vibrio cholerae: Understanding the ecology of resistance genes and mechanisms. Vaccine. 2020 Feb 29;38 Suppl 1:A83-A92. doi: 10.1016/j.vaccine.2019.06.031. Epub 2019 Jul 2. PMID: 31272870.(Corresponding author)
47. Pant A, Das B, Bhadra RK. CTX phage of Vibrio cholerae: Genomics and applications. Vaccine. 2020 Feb 29;38 Suppl 1:A7-A12. doi: 10.1016/j.Vaccine. 2019.06.034. Epub 2019 Jul 1. PMID: 31272871.(Corresponding author)
46.Ramamurthy T, Das B, Chakraborty S, Mukhopadhyay AK, Sack DA. Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139. Vaccine. 2020 Feb 29;38 Suppl 1:A73-A82. doi: 10.1016/j.vaccine.2019.07.099. Epub 2019 Aug 16. PMID: 31427135.
45. Das B.Nair GB. Homeostasis and dysbiosis of the gut microbiome in health and disease. J Biosci. 2019 Oct;44(5):117. PMID: 31719226.(Corresponding author)
44. Senapati T, Kothidar A, Banerjee SK, Das B. Insights into the gastrointestinal tract microbiomes of Indian population. J Biosci. 2019 Oct;44(5):113. PMID: 31719222.(Corresponding author)
43. Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T. Diphtheria. Nat Rev Dis Primers. 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499.
42. Verma J, Bag S, Saha B, Kumar P, Ghosh TS, Dayal M, Senapati T, Mehra S, Dey P, Desigamani A, Kumar D, Rana P, Kumar B, Maiti TK, Sharma NC, Bhadra RK, Mutreja A, Nair GB, Ramamurthy T, Das B. Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6226-6231. doi: 10.1073/pnas.1900141116. Epub 2019 Mar 13. PMID: 30867296; PMCID: PMC6442563.(Corresponding author)
41.Adela R, Reddy PNC, Ghosh TS, Aggarwal S, Yadav AK, Das B, Banerjee SK. Serum protein signature of coronary artery disease in type 2 diabetes mellitus. J Transl Med. 2019 Jan 24;17(1):17. doi: 10.1186/s12967-018-1755-5. PMID: 30674322; PMCID: PMC6345069.
40. Das B,Ghosh TS, Kedia S, Rampal R, Saxena S, Bag S, Mitra R, Dayal M, Mehta O, Surendranath A, Travis SPL, Tripathi P, Nair GB, Ahuja V. Analysis of the Gut Microbiome of Rural and Urban Healthy Indians Living in Sea Level and High Altitude Areas. Sci Rep. 2018 Jul 4;8(1):10104. doi: 10.1038/s41598-018-28550-3. PMID: 29973712; PMCID: PMC6031670.(Corresponding author)
39. Bag S, Ghosh TS, Banerjee S, Mehta O, Verma J, Dayal M, Desigamani A, Kumar P, Saha B, Kedia S, Ahuja V, Ramamurthy T, Das B. Molecular Insights into Antimicrobial Resistance Traits of Commensal Human Gut Microbiota. Microb Ecol. 2019 Feb;77(2):546-557. doi: 10.1007/s00248-018-1228-7. Epub 2018 Jul 16. PMID: 30009332.(Corresponding author)
38. Sarkar S., Das B., Banerjee S.K., (2018). Insights into the Human Gut Microbiome and Cardiovascular Diseases. J. Prac. Card. Sci.2018;4:10-4. (Corresponding author)
37. Kumar A, Bag S, Das B. Novel Genetic Tool to Study the Stability of Genomic Islands. Recent Pat Biotechnol. 2018;12(3):200-207. doi: 10.2174/1872208312666180223113618. PMID: 29473528.(Corresponding author)
36. Das B,Chaudhuri S, Srivastava R, Nair GB, Ramamurthy T. Fostering research into antimicrobial resistance in India. BMJ. 2017 Sep 6;358:j3535. doi: 10.1136/bmj.j3535. PMID: 28877874; PMCID: PMC5582344.(Corresponding author)
35. Bag S, Ghosh TS, Das B. Complete Genome Sequence of Faecalibacterium prausnitzii Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Nov 16;5(46):e01286-17. doi: 10.1128/genomeA.01286-17. PMID: 29146862; PMCID: PMC5690339.(Corresponding author)
34. Bag S, Ghosh TS, Das B. Complete Genome Sequence of Collinsella aerofaciens Isolated from the Gut of a Healthy Indian Subject. Genome Announc. 2017 Nov 22;5(47):e01361-17. doi: 10.1128/genomeA.01361-17. PMID: 29167267; PMCID: PMC5701492.(Corresponding author)
33. Kumar P, Bag S, Ghosh TS, Dey P, Dayal M, Saha B, Verma J, Pant A, Saxena S, Desigamani A, Rana P, Kumar D, Sharma NC, Hanpude P, Maiti TK, Mukhopadhyay AK, Bhadra RK, Nair GB, Ramamurthy T, Das B. Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India. Sci Rep. 2017 Oct 31;7(1):14468. doi: 10.1038/s41598-017-14791-1. PMID: 29089611; PMCID: PMC5663842.(Corresponding author)
32. Bag S, Ghosh TS, Das B. Whole-Genome Sequence of a Megasphaera elsdenii Strain Isolated from the Gut of a Healthy Indian Adult Subject. Genome Announc. 2017 Oct 19;5(42):e01033-17. doi: 10.1128/genomeA.01033-17. PMID: 29051237; PMCID: PMC5646390.(Corresponding author)
31. Das A, Pereira V, Saxena S, Ghosh TS, Anbumani D, Bag S, Das B, Nair GB, Abraham P, Mande SS. Gastric microbiome of Indian patients with Helicobacter pylori infection, and their interaction networks. Sci Rep. 2017 Nov 13;7(1):15438. doi: 10.1038/s41598-017-15510-6. PMID: 29133866; PMCID: PMC5684312. (Top 100 read microbiology article for Scientific Reports in 2017).
30. Bag S, Ghosh TS, Das B. Whole-Genome Sequence of Bifidobacterium longum Strain Indica, Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Oct 12;5(41):e01017-17. doi: 10.1128/genomeA.01017-17. PMID: 29025929; PMCID: PMC5637489.(Corresponding author)
29.Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, Mazumder S. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017 Oct 2;3:17067. doi: 10.1038/cddiscovery.2017.67. PMID: 29142761; PMCID: PMC5680545.
28. Bag S, Ghosh TS, Das B. Draft Genome Sequence of Prevotella copri Isolated from the Gut of a Healthy Indian Adult. Genome Announc. 2017 Sep 14;5(37):e00834-17. doi: 10.1128/genomeA.00834-17. PMID: 28912310; PMCID: PMC5597751.(Corresponding author)
27. Das B,Pazhani GP, Sarkar A, Mukhopadhyay AK, Nair GB, Ramamurthy T. Molecular evolution and functional divergence of Vibrio cholerae. Curr Opin Infect Dis. 2016 Oct;29(5):520-7. doi: 10.1097/QCO.0000000000000306. PMID: 27537830.
26. Bag S, Saha B, Mehta O, Anbumani D, Kumar N, Dayal M, Pant A, Kumar P, Saxena S, Allin KH, Hansen T, Arumugam M, Vestergaard H, Pedersen O, Pereira V, Abraham P, Tripathi R, Wadhwa N, Bhatnagar S, Prakash VG, Radha V, Anjana RM, Mohan V, Takeda K, Kurakawa T, Nair GB, Das B. An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples. Sci Rep. 2016 May 31;6:26775. doi: 10.1038/srep26775. PMID: 27240745; PMCID: PMC4886217.(Corresponding author)
25. Rakonjac J, Das B, Derda R. Editorial: Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Front Microbiol. 2016 Dec 23;7:2109. doi: 10.3389/fmicb.2016.02109. PMID: 28066406; PMCID: PMC5179506.
24. Chowdhury G, Bhadra RK, Bag S, Pazhani GP, Das B, Basu P, Nagamani K, Nandy RK, Mukhopadhyay AK, Ramamurthy T. Rugose atypical Vibrio cholerae O1 El Tor responsible for 2009 cholera outbreak in India. J Med Microbiol. 2016 Oct;65(10):1130-1136. doi: 10.1099/jmm.0.000344. Epub 2016 Aug 25. PMID: 27561681.
23. Pant A, Anbumani D, Bag S, Mehta O, Kumar P, Saxena S, Nair GB, Das B. Effect of LexA on Chromosomal Integration of CTXÏ• in Vibrio cholerae. J Bacteriol. 2015 Oct 26;198(2):268-75. doi: 10.1128/JB.00674-15. PMID: 26503849; PMCID: PMC4751795.(Corresponding author)
22. Das B. Mechanistic insights into filamentous phage integration in Vibrio cholerae. Front Microbiol. 2014 Nov 28;5:650. doi: 10.3389/fmicb.2014.00650. PMID: 25506341; PMCID: PMC4246890.(Corresponding author)
21. Das B, Kumari R, Pant A, Sen Gupta S, Saxena S, Mehta O, Nair GB. A novel, broad-range, CTXΦ-derived stable integrative expression vector for functional studies. J Bacteriol. 2014 Dec;196(23):4071-80. doi: 10.1128/JB.01966-14. Epub 2014 Sep 15. PMID: 25225263; PMCID: PMC4248877.(Corresponding author)
20. Banerjee R, Das B, Balakrish Nair G, Basak S. Dynamics in genome evolution of Vibrio cholerae. Infect Genet Evol. 2014 Apr;23:32-41. doi: 10.1016/j.meegid.2014.01.006. Epub 2014 Jan 23. PMID: 24462909.
19. Midonet C, Das B, Paly E, Barre FX. XerD-mediated FtsK-independent integration of TLCÏ• into the Vibrio cholerae genome. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16848-53. doi: 10.1073/pnas.1404047111. Epub 2014 Nov 10. PMID: 25385643; PMCID: PMC4250166.
18. Das B., Nair G.B., Bhadra R.K. (2014). Acquisition and dissemination mechanisms of CTXΦ in Vibrio cholerae: New paradigm for dif residents. World J Med Genet. 4: 27-33.
17. Bag S, Das B, Dasgupta S, Bhadra RK. Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis. Arch Microbiol. 2014 Aug;196(8):575-88. doi: 10.1007/s00203-014-0996-9. Epub 2014 May 24. PMID: 24859914.
16. Kim EJ, Lee D, Moon SH, Lee CH, Kim SJ, Lee JH, Kim JO, Song M, Das B, Clemens JD, Pape JW, Nair GB, Kim DW. Molecular insights into the evolutionary pathway of Vibrio cholerae O1 atypical El Tor variants. PLoS Pathog. 2014 Sep 18;10(9):e1004384. doi: 10.1371/journal.ppat.1004384. PMID: 25233006; PMCID: PMC4169478.
15.Ghosh TS, Gupta SS, Bhattacharya T, Yadav D, Barik A, Chowdhury A, Das B, Mande SS, Nair GB. Gut microbiomes of Indian children of varying nutritional status. PLoS One. 2014 Apr 24;9(4):e95547. doi: 10.1371/journal.pone.0095547. PMID: 24763225; PMCID: PMC3999041.
14. Das B, Martínez E, Midonet C, Barre FX. Integrative mobile elements exploiting Xer recombination. Trends Microbiol. 2013 Jan;21(1):23-30. doi: 10.1016/j.tim.2012.10.003. Epub 2012 Nov 2. PMID: 23127381.
13. Pal RR, Bag S, Dasgupta S, Das B, Bhadra RK. Functional characterization of the stringent response regulatory gene dksA of Vibrio cholerae and its role in modulation of virulence phenotypes. J Bacteriol. 2012 Oct;194(20):5638-48. doi: 10.1128/JB.00518-12. Epub 2012 Aug 17. PMID: 22904284; PMCID: PMC3458680.
12. Das B, Bischerour J, Barre FX. VGJphi integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2516-21. doi: 10.1073/pnas.1017061108. Epub 2011 Jan 24. PMID: 21262799; PMCID: PMC3038760.
11. Das B,Bischerour J, Barre FX. Molecular mechanism of acquisition of the cholera toxin genes. Indian J Med Res. 2011 Feb;133(2):195-200. PMID: 21415494; PMCID: PMC3089051.
10.Pal RR, Das B, Dasgupta S, Bhadra RK. Genetic components of stringent response in Vibrio cholerae. Indian J Med Res. 2011 Feb;133(2):212-7. PMID: 21415497; PMCID: PMC3089054.
9. Majumdar T, Das B, Bhadra RK, Dam B, Mazumder S. Complete nucleotide sequence of a quinolone resistance gene (qnrS2) carrying plasmid of Aeromonas hydrophila isolated from fish. Plasmid. 2011 Jul;66(2):79-84. doi: 10.1016/j.plasmid.2011.05.001. Epub 2011 Jun 12. PMID: 21664930.
8. Das B, Bischerour J, Val ME, Barre FX. Molecular keys of the tropism of integration of the cholera toxin phage. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4377-82. doi: 10.1073/pnas.0910212107. Epub 2010 Jan 21. PMID: 20133778; PMCID: PMC2840090.
7. Halder K, Das B, Nair GB, Bhadra RK. Molecular evidence favouring step-wise evolution of Mozambique Vibrio cholerae O1 El Tor hybrid strain. Microbiology (Reading). 2010 Jan;156(Pt 1):99-107. doi: 10.1099/mic.0.032458-0. Epub 2009 Oct 1. PMID: 19797359.
6. Das B,Pal RR, Bag S, Bhadra RK. Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene. Mol Microbiol. 2009 Apr;72(2):380-98. doi: 10.1111/j.1365-2958.2009.06653.x. Epub 2009 Mar 4. PMID: 19298370.
5. Das B,Bhadra RK. Molecular characterization of Vibrio cholerae DeltarelA DeltaspoT double mutants. Arch Microbiol. 2008 Mar;189(3):227-38. doi: 10.1007/s00203-007-0312-z. Epub 2007 Oct 30. PMID: 17968531.
4. Shah S, Das B, Bhadra RK. Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae. J Bacteriol. 2008 Jul;190(13):4764-71. doi: 10.1128/JB.02021-07. Epub 2008 May 2. PMID: 18456812; PMCID: PMC2446790.
3. Bhowmick R, Ghosal A, Das B, Koley H, Saha DR, Ganguly S, Nandy RK, Bhadra RK, Chatterjee NS. Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin. Infect Immun. 2008 Nov;76(11):4968-77. doi: 10.1128/IAI.01615-07. Epub 2008 Sep 2. PMID: 18765724; PMCID: PMC2573318.
2. Das B,Halder K, Pal P, Bhadra RK. Small chromosomal integration site of classical CTX prophage in Mozambique Vibrio cholerae O1 biotype El Tor strain. Arch Microbiol. 2007 Dec;188(6):677-83. doi: 10.1007/s00203-007-0275-0. Epub 2007 Jul 6. PMID: 17618421.
1.Maiti D, Das B, Saha A, Nandy RK, Nair GB, Bhadra RK. Genetic organization of pre-CTX and CTX prophages in the genome of an environmental Vibrio cholerae non-O1, non-O139 strain. Microbiology (Reading). 2006 Dec;152(Pt 12):3633-3641. doi: 10.1099/mic.0.2006/000117-0. PMID: 17159216.
1. Paul D., Verma J., Banerjee A., Konar D., Das B. (2022) Antimicrobial Resistance Traits and Resistance Mechanisms in Bacterial Pathogens. Pages 1-27. Editors: V. Kumar, V. Shriram, A. Paul M. Thakur. Springer Link. ISBN: 978-981-16-3120-7
2. Ahrodia T., Wadhwa N., Das B. (2021) Gut Microbiome Signatures in Health and Diseases. Elsevier Food Science, ISBN 9780081005965, doi.org/10.1016/B978-0-12-819265-8.00067-X
3. Ramamurthy T., Mukhopadhyay A. Das B. Nandy R., Mutreja A., Weill F.X., Nair G.B. (2020) Molecular Typing of Vibrio cholerae: Imprints in the Epidemiology of Cholera in “Molecular Typing in Bacterial Infections” Editors: Ivano de Filippis and Marian L. McKee. Publisher: Springer Nature Publishing.
4. Matta T., Purohit A., Das B. (2020). "Human reproductive tract microbiome and birth outcomes" in “Recent Advances in Obstetrics and Gynaecology”. Editor: Aruna Nigam. Evangel Publisher.
5. Das B., Saxena S., Mehta O., Bhadra R.K., Nair G.B. (2019). The human microbiota in health and disease. In Probiotics in Health: Emerging Opportunities (Edited by Takeda Y., Nair G.B., Kurpad A.). Publisher: Wiley India.
6. eBook (2017): Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Edited by: Rakonjac J., Das B., Derda R. Publisher: Frontiers Media SA. ISBN: 9782889450954
7. Dasgupta S., Das B., Basu P., Bhadra R.K. (2016) Molecular basis of stringent response in Vibrio cholerae (Edited by Frans J. de Bruijn. John Wiley & Sons, Inc, USA). P. 507-516 Aug 2016
8. Nair G.B., Sen Gupta S., Das B. (2014). The “Uncultured” but significant world of the human gut microbiome: New metagenomic insights. In G. P. Talwar and L.M. Srivastava (Eds.), Textbook of Biochemistry and Human Biology (pp. 664-671). Delhi, India: PHI Learning Pvt. Ltd.
9. Das B. and Nair G.B. (2012). The genomics of Cholera. In ‘Genomics Applications for the Developing World’ (Eds. Karen E. Nelson & Barbara jones-Nelson) Springer publication, USA pp. 21-38, DOI: 10.1007/978-1-4614-2182-5_3.
10. Bhadra R.K., Shah S., Das B. (2010). Small Molecule Signaling Systems in Vibrio cholerae. In ‘Epidemiological and Molecular Aspects on Cholera’ (Eds. Ramamurthy T. & Bhattacharya S. K.). Humana Press, USA, pp. 185-201.
11. Bhadra R.K. and Das B. (2008). Coordinated regulation of gene expression in Vibrio cholerae. In ‘Vibrio cholerae: Genomics and Molecular Biology’ (Eds. Faruque, S.M. & Nair, G.B). Caister Academic Press, UK, pp. 153-167.
Bhabatosh Das, Shruti Panwar, Nitya Wadhwa, Roshan Kumar: Title: Universal microbial sample transport medium for genomic and metagenomic studies. Patent application no. 202211023269. Year: 2022
Bhabatosh Das, Archana Pant, Jyoti Verma, Shailendra Vyas: Title: Integrative Expression Vector. Patent application no. 201911046890; Year: 2019.
Young Scientist Award from International Life Sciences Institute-India for Improving Public Health in the Areas of Food Safety, Nutrition and Wellbeing (2021)
- BMGF Travel Grant Award to attend 52nd US-Japan Joint Panel Conference on Cholera and Other Bacterial Enteric Infections (2018)
- Invited Member of GTFCC in World Health Organization (WHO) (2010-Till)
- Young Investigator Award (1st prize) from Yakult India Microbiota and Probiotic Science Foundation, 2016
Editoral Board Member
- Microbial Ecology (Editoreal Board Member)
- Gut Microbiome (Editoreal Board Member)
- Frontiers in Microbiology (Guest Associate Editor)
- Frontiers in Genetics (Guest Associate Editor)
- EC Microbiology (Editoreal Board Member)
- Best Poster Award in Conference/Symposium
• Best Poster Award (2018) in Biozest 2018 for research on the CTX-phage replication and integration. Organizers: South Asian University, New Delhi on 6th December 2018.
Title: Deciphering the host bacterial factors essential for integration and replication of CTX-phage
Presenting author: Archana Pant, Corresponding author: Bhabatosh Das.
• Best Poster Award (2018) in the international Probiotic Symposium “Probiotics through the Lifespan” for research on the Gut Microbiome and Antimicrobial resistance (24th-25th November 2018). Organizers: NICED, Kolkata; ILDS, Kolkata; Amity University, Kolkata.
Title: Gut microbiome is the epicenter for dissemination of antimicrobial resistance traits
Presenting author: Jyoti Verma, Corresponding author: Bhabatosh Das.
• Best Poster Award (2018) for Antimicrobial resistance research in the international Probiotic Symposium, “ Probiotics through the Lifespan” (24-25 Nov. 2018). Organizers: NICED, Kolkata; ILDS, Kolkata; Amity University, Kolkata.
Title: Role of gut microbiota in the emergence of colistin resistant enteric pathogens
Presenting author: Tarosi Senapati, Corresponding author: Bhabatosh Das.
• Best Poster Award (2018) in the International Symposium on Infectious Diseases (12-14 November) for Antimicrobial resistance research. Organizer: Regional Centre for Biotechnology, Faridabad and Jamia Hamdard, Delhi.
Title: Insights into the resistance traits of multidrug resistant enteric pathogens isolated from India
Presenting author: Satyabrata Bag, Corresponding author: Bhabatosh Das.
• Best Poster Award (2018) in the International Conference on Antiâ€Microbial Resistance (16-17 Feb. 2018) for Antimicrobial resistance research. Organizer: NIPER, Kolkata and NICED Kolkata.
Title: Molecular insights into antimicrobial resistance traits of multi drug resistant commensal human gut microbiota
Presenting author: Satyabrata Bag, Corresponding author: Bhabatosh Das.
• Best Poster Award (2018) in the NIPGR and THSTI Open day (28th September) for Antimicrobial resistance research.
Title: Antibiotic resistance in commensal and pathogenic bacteria
Presenting author: Jyoti Verma, Corresponding author: Bhabatosh Das.
• Best Poster Award (2017) in “Cardiovascular Research Convergence” conference on 12th and 19th August 2017 for Human Microbiome research . Organizers: AIIMS-Delhi and THSTI-Faridabad.
Title: Gut Microbiome in Inflammatory Bowel Disease: A Comparative analysis in the Indian population
Presenting author: Tarini Shankar Ghosh. Corresponding author: Bhabatosh Das
• Best Poster Award (2017) in “THSTI foundation day for Human Microbiome research. Organizer: THSTI.
Title: Insights into the Gut Microbiome of Inflammatory Bowel Disease patients living in different parts of India
Presenting author: Tarini Shankar Ghosh. Corresponding author: Bhabatosh Das.
Guest Speaker (Webinar talk 2021): Organized by the Calcutta University on 1st March 2021.
Title: Genetic nature and dynamics of antibiotic resistance traits in the commensal and pathogenic enteric bacteria
Guest Speaker (Webinar talk 2021): Organized by the Amrtita Vishwa Vidyapeetham on 26 February 2021.
Title: Genomics of Extensively Drug Resistant Enteric Bacterial Pathogens Isolated from India
Guest Speaker (Webinar talk 2021): Organized by the Savitribai Phule Pune University, Pune on 2nd February 2021
Title: Understanding role of human gut microbiome in the emergence and spread of antibiotic resistant enteric bacterial pathogens
Guest Speaker (2020, webinar talk): Organised by the Dept. of Gastroenterology, AIIMS New Delhi on 18th August 2020
Title: Homeostasis and Dysbiosis of the Human Gut Microbiome in Health and Diseases
Guest Speaker (2020, webinar talk): Organised by the School of Biotechnology, Presidency University, Kolkata on 6-7 August 2020
Title: Human Microbiome in Health and Diseases
Guest Speaker (2020, webinar talk): Organised by the Dept. of Science and Technology (DST), Govt. of Rajasthan on 12th April 2020
Title: Human Microbiome in Health and Diseases
Guest Speaker (2020, webinar talk): Organised by the Sidho-Kanho-Birsha-University, WB on 8th June 2020
Title: Molecular insights into COVID-19 and its pathogen SARS-CoV-2
Guest Speaker (2020, webinar talk): Organised by the Adamas University, Kolkata on 6th July 2020.
Title: Gut Microbiome: Associations, Functions and Implications for therapeutics
Guest Speaker (2020): 10th India probiotic symposium on “Cutting edge science and applications: Intestinal microbiota and Probiotics” organized by the Probiotic Science Foundation on 29th February-1st March 2020 at The Suryaa, New Delhi.
Title: Diet and the Gut Microbiome: Applications, Functions and Implications for Therapeutics.
Keynote Speaker (2019): Seminar on "Current Challenges of antimicrobial Resistance and Potential Intervention by Bacteriophages" organized by the ICMR-NICED on 16th and 17th September at Hyatt Regency Kolkata.
Title: Insights into Antimicrobial Resistance in Human Associated Microbes.
Guest Speaker (2019): International India|EMBO Symposium on Human Microbiome organized by J. Craig Venter Institute, US and National Institute of Biomedical Genomics, IN on 9-12 Nov, 2019.
Title: Role of vaginal microbiome in preterm birth
Guest Speaker (2019): National seminar on Next Generation DNA sequencing organized by Pondicherry University, India on 12-13 Dec, 2019.
Title: Next Generation Sequencing Technology and Application.
Guest Speaker (2019): National Institute of Pharmaceutical Education and Research (NIPER) Kolkata on 7th November 2019.
Title: Insights into antibiotic resistance in human associated gut microbiota
Guest Speaker (2019): Frontiers in Biological Sciences. Organizers: (i) St. Xavier's College, (ii) Presidency University (iii) CSIR-IICB, Kolkata.
Title: Understanding the role of human gut microbiome in the emergence of antibiotic resistant enteric bacterial pathogens
Guest Speaker (2019): Workshop on Translational Health at The International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi on 11th - 15th March 2019.
Title: Structure, functions and dynamics of gut microbiome of Indian population living in rural and urban areas.
Guest Speaker (2019): All India Institute of Medical Sciences (AIIMS), New Delhi (2nd March. 2019)
Guest Speaker (2019): All India Institute of Medical Sciences (AIIMS), New Delhi (23rd Feb. 2019)
Title: Human Microbiome: Concept, Approaches and Implications
Guest Speaker (2018): 59th Annual Conference of Association of Microbiologist of India & International Symposium on Host Pathogen Interactions organized at University of Hyderabad on 9-12 December 2018.
Title: Role of Gut Microbiota of Healthy Human in the Emergence of Resistance Pathogens
Guest Speaker (2018): International Conference on “Role of Probiotics in Promoting Healthy Microbiome for Health and Immunity” organized by International Life Science Institute-India, New Delhi on 6th December 2018.
Title:Impact of Microbial Community DNA Extraction Method on Human Microbiome Study
Guest Speaker (2018): 9th India Probiotic Symposium organized by the Gut Microbiota and Probiotic Science Foundation in association with Amity University, Kolkata, National Institute of Cholera and Enteric Diseases (NICED), Kolkata and the Indian Institute of Liver and Digestive Sciences, Kolkata on 24th - 25th November 2018.
Title: GutMicrobiome of Healthy Indian Population Living in Urban and Rural Areas
Guest Speaker (2018): International Conference on Microbiome Research (ICMR) 2018, National Centre For Cell Science, Pune on 19th - 22nd November 2018.
Title:Gut Microbiome of Indian Population in Health and Diseases
Guest Speaker (2018): Institute of Life Sciences, Bhubaneswar 4th September 2018.
Title: Gut Microbiome of Indian Population in Health and Diseases
Guest Speaker (2018): Workshop and seminar on Translational research in biomedical and agricultural sciences, All India Institute of Medical Sciences, New Delhi, 6th – 7th July 2018.
Title:Molecular Insights into Antimicrobial Resistance Traits of Human Gut Microbiota
Guest Speaker (2018): Manipal Academy of Higher Education, Manipal 14th March 2018
Title: Current Understanding of the Human Microbiome
Guest Speaker (2018): Current trends in Genomics at Aligarh Muslim University, Aligarh on 21 March 2018.
Title: Genomics of commensal and pathogenic enteric bacteria: AMR perspectives
Guest Speaker (2018): NASH-context and Research at Indian Institute of liver and digestive Sciences, Kolkata on 6th February 2018.
Title: Microbiome and Metabolic Diseases
Guest Speaker (2017): Graduate School of Medicine, Osaka University, Japan on 27th October 2017.
Title: Insights into Gut Microbiome of Indian Population in Health and Diseases
Speaker and organizing secretary (2017): Indo-US Workshop on Genomics and Bioinformatics to Explore Human Microbial Ecology in Health and Diseasesorganized by THSTI on September 6th-8th 2017.
Title:Human Microbiome Research in THSTI: Understanding and Challenges
Guest Speaker (2017): at national conference onCardiovascular Research Convergence Organized by AIIMS-Delhi and THSTI-Faridabad on 12th August 2017.
Title:Diversity, stability and resilience of human gut microbiota
Guest Speaker ((2017)): Faculty Development Programme at Kalinga Institute of Medical Sciences (KIMS) KIIT University, Bhubneswar, 29th June 2017
Title: Dysbiosis: How to measure it and its association with various diseases
Guest Speaker (2017): Institute of Post-Graduate Medical Education & Research, Kolkata on 26th May 2017
Title:Microbiome in Liver diseases
Guest Speaker (2017): at National Institute of Science Education and Research (NISER), 7th February 2017
Title: Antimicrobial Resistant Enteric Pathogens: Molecular Insights into Resistance Traits of Isolates from Indian
Guest Speaker (2017): at National Institute of Science Education and Research (NISER), 6th February 2017
Title: Gut microbiome of the Indian Population: Current Understanding and Future Challenges
Guest Speaker (2017): SUPERBUGS V/S SUPERDRUGS: The Looming Global Antibiotic Resistance Crisis, Amrita School of Biotechnology, Amritapuri, Kollam, Kerala (19th to 20th January 2017)
Title:Multidrug Resistant Enteric Pathogens: Molecular Insights into Resistance Traits of Isolates from Indian
Guest Speaker (2016): 40th Annual Conference of Indian Association of Medical Microbiologists, PGIMER, Chandigarh (23rd to 27th November 2016)
Title: Microbiome of the Indian Population: Current Understanding and Future Challenges
Young Investigator Presentation (2016): Probiotics in Health-Emerging Opportunities, Chennai (3rd to 4th December 2016)
Title: The Gut Microbiome of Healthy Indians: Findings and Challenges
Invited participant (2016): WHO Global Workshop on Strengthening Integrated Surveillance of Foodborne Diseases and Antimicrobial Resistance through the Whole Genome Sequencing methods.(4th to 8th April 2016)
Venue: Thammasat University, Bangkok, Thailand
Selected Participant (2016): Advance Course on Antibiotics (AdCAb). Les Pensieres, France, (9th to 20th October 2016)
Guest Speaker (2016): 3rd Biennial Conference & International Symposium on Stress, Microbiome & Probiotics, NISER Bhubneswar, Odisha (11-13 March 2016)
Title: Antimicrobial Resistant Enteric Pathogens: Genomics Advances and Future Perspectives
Guest Speaker (2015) : 56th Annual Conference of Association of Microbiologists of India (AMI 2015), JNU, New Delhi (7th-10th December 2015)
Title:Antibiotic resistance: Molecular insights into resistance traits of human enteric pathogens
Guest Speaker (2015): Provocative ideas on Human Placental Biology;Department of Biotechnology, Ministry of Science and Technology, Govt. of India, New Delhi.(1st -2nd December 2015)
Title:Placental microbiome and its role in pregnancy outcomes
Guest Speaker (2015): International workshop on applications of systems and mathematical biology in public health, NISER, Bhubneswar.(22nd -24th February 2015)
Title:Guanosine penta- and tetraphosphate metabolisms in bacteria and implications in gut microbiota homeostasis
Guest Speaker (2014): Indo-German Bilateral Workshops on “Diagnostics of Translational Genome Sequencing in Clinical and Public Health Microbiology” Organized by the Madras Medical Mission (MMM), Chennai, India.(19th-21stMarch 2014)
Title:Functional Metagenomics: Dissemination of Antibiotic Resistance Traits in Bacterial Pathogens
(1) Nutra Ingradients USA (24 September 2018)
Title: Microbiome insights
(2) The Hindu (26th August 2018)
Title: A nursery of drug resistance
(3) BusinessLines (21st August 2018)
Gut bacteria are a reservoir of drug resistance genes: study
(4) Nature India(29 July 2018)
Pathogens pick up drug resistance genes from friendly bacteria
(5) Nature India (July11, 2018)
Rural Indians have healthier guts than urban folks
(6) Dept. of Biotechnology, Govt. of India (July 23, 2018)
Richness, functions and diversity of the gut microbiome of healthy Indians
(7) Vigyan Prasar, Dept. of Science and Technology, Govt. of India (July 19, 2018)
A peek into gut of Indians throws up surprises
(8) The Hindu (July 22, 2018)
What your gut is telling you
(9) Hindustan Times (July 22, 2018)
Vegetarian diet helps keep Indian gut healthy: Study
(10) Deccan Herald (23rd July, 2018)
Scientists map gut microbiota of Indians
(11) The Hindu (15th October 2017)
We need to talk about AMR
(12) Fountain ink (17th May 2017)
The body’s secret garden: How the exploration of the microbiome is going to change face of medicine
(13) Dept. of Biotechnology, Govt. of India (2015)
Scientists in THSTI Develop Novel Genetic Tools to speed up Drug Discovery Research
(14) Times of India (Aug 17, 2015)
Research roundup: Vector-wise
(14) Times of India (Aug 17, 2015)
Research roundup: Vector-wise
MS.SONALI POREY KARMAKAR
DR.AGILA KUMARI P.
PRINCIPAL PROJECT ASSOCIATE
JUNIOR RESEARCH SCIENTIST
MS.J R YODHAANJALI
SENIOR PROJECT ASSOCIATE