Renowned Scientist, Dr. Thomas Steinbrecher, Director of Applications Sciences, Europe, Schrodinger visited THSTI on 23 rd June 2022 to deliver a talk on “From Ideas to Medicines- Discovery of clinical candidates with an ML-driven physics-based technology platform.” In his address, he explained physics based modeling, make-on-demand commercial libraries and machine learning models. Dr. Steinbrecher explained the Schrödinger molecular design platform that covers methods ranging from ultra-fast, approximate approaches through a range of AI-enhanced physics-based in-silico simulation methods to advanced ligand docking approaches to drug discovery. He also presented numerous successful case studies across a number of discovery programs along with their recent advances. Post lecture, Dr. Steinbrecher interacted with the faculty, scientists and students from the computational group of THSTI and had a brain-storming session on compound optimization using thermodynamics profiling and free energy perturbation.