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  • ट्रांसलेशनल हेल्थ साइंस एंड टेक्नोलॉजी इंस्टीट्यूट
  • TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE
    AN INSTITUTE OF BIOTECHNOLOGY RESEARCH AND INNOVATION COUNCIL
    DEPT. OF BIOTECHNOLOGY, MINISTRY OF SCIENCE AND TECHNOLOGY
    GOVT OF INDIA
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  • Faculty Profile

DR.SRIKANTH SADHU

Ph.D.

RESEARCH SCIENTIST

  • MSc, Department of Animal Biotechnology, UoH
Publication

1. Malik S, Sadhu S, Elesela S, Pandey RP, Chawla AS, Sharma D, Panda L, Rathore D, Ghosh B,   Ahuja V, Awasthi A. Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Nat Commun. 2017 Oct 9;8(1):815. doi: 10.1038/s41467-017-00674-6. PMID: 28993609; PMCID: PMC5634439.

2. Rizvi ZA, Dalal R, Sadhu S, Kumar Y, Kumar S, Gupta SK, Tripathy MR, Rathore DK, Awasthi A. High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity. Sci Adv. 2021 Sep 10;7(37):eabg5016. doi: 10.1126/sciadv.abg5016. Epub 2021 Sep 10. PMID: 34516769; PMCID: PMC8442882.

3. Rizvi ZA, Dalal R, Sadhu S, Binayke A, Dandotiya J, Kumar Y, Shrivastava T, Gupta SK, Aggarwal S, Tripathy MR, Rathore DK, Yadav AK, Medigeshi GR, Pandey AK, Samal S, Asthana S, Awasthi A. Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection. Elife. 2022 Jan 11;11:e73522. doi: 10.7554/eLife.73522. PMID: 35014610; PMCID: PMC8794466. (Co. first Author)

4. Khatri R, Siddqui G, Sadhu S, Maithil V, Vishwakarma P, Lohiya B, Goswami A, Ahmed S, Awasthi A, Samal S. Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters fusogenicity and infectivity. Med Microbiol Immunol. 2023 Feb;212(1):103-122. doi: 10.1007/s00430-022-00760-7. Epub 2022 Dec 30. PMID: 36583790; PMCID: PMC9801140.

5. Rizvi ZA, Babele P, Sadhu S, Madan U, Tripathy MR, Goswami S, Mani S, Kumar S, Awasthi A, Dikshit M. Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. Front Immunol. 2022 Sep 27;13:945583. doi: 10.3389/fimmu.2022.945583. PMID: 36238303; PMCID: PMC9550929. (Second Author)

6. Sadhu S, Rizvi ZA, Pandey RP, Dalal R, Rathore DK, Kumar B, Pandey M, Kumar Y, Goel R, Maiti TK, Johri AK, Tiwari A, Pandey AK, Awasthi A. Gefitinib Results in Robust Host-Directed Immunity Against Salmonella Infection Through Proteo-Metabolomic Reprogramming. Front Immunol. 2021 Mar 31;12:648710. doi: 10.3389/fimmu.2021.648710. PMID: 33868285; PMCID: PMC8044459.

7. Rizvi ZA, Babele P, Madan U, Sadhu S, Tripathy MR, Goswami S, Mani S, Dikshit M, Awasthi A. Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions. Front Immunol. 2023 Mar 7;14:1138215. doi: 10.3389/fimmu.2023.1138215. PMID: 36960064; PMCID: PMC10028191.

8. Sadhu, S., Dalal, R., Dandotiya, J. Binayke A, Virendra S, Awasthi A. IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation. Nat Commun 14, 4060 (2023). https://doi.org/10.1038/s41467-023-39815-5.

9. Sadhu S, Dandotiya J, Dalal R, Khatri R, Mykytyn AZ, Batra A, Kaur M, Chandwaskar R, Singh V, Kamboj A, Srivastava M, Mani S, Asthana S, Samal S, Rizvi ZA, Salunke DB, Haagmans BL, Awasthi A. Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry. Antiviral Res. 2023 Dec;220:105743. doi: 10.1016/j.antiviral.2023.105743. Epub 2023 Nov 8. PMID: 37949319.

10. Rizvi ZA, Dandotiya J, Sadhu S, Khatri R, Singh J, Singh V, Adhikari N, Sharma K, Das V, Pandey AK, Das B, Medigeshi G, Mani S, Bhatnagar S, Samal S, Pandey AK, Garg PK, Awasthi A. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice. Commun Biol. 2023 Sep 13;6(1):935. doi: 10.1038/s42003-023-05263-6. PMID: 37704701; PMCID: PMC10499788.

11. Dalal R, Sadhu S, Awasthi A, Role of Th17 cell in tissue inflammation and organ-specific autoimmunity. Translational Autoimmunity. Book chapter. 93-121(Equally Contributed).

12. Roy SS, Sharma S, Rizvi ZA, Sinha D, Gupta D, Rophina M, Sehgal P, Sadhu S, Tripathy MR, Samal S, Maiti S, Scaria V, Sivasubbu S, Awasthi A, Harshan KH, Jain S, Chowdhury S. G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters. Front Mol Biosci. 2023 Mar 16;10:1133123. doi: 10.3389/fmolb.2023.1133123. PMID: 37006620; PMCID: PMC10061221.

13. Rizvi ZA, Sadhu S, Dandotiya J, Sharma P, Binayke A, Singh V, Das V, Khatri R, Kumar R, Samal S, Kalia M, Awasthi A. SARS-CoV-2 infection induces thymic atrophy mediated by IFN-γ in hACE2 transgenic mice. Eur J Immunol. 2024 Jul;54(7):e2350624. doi: 10.1002/eji.202350624. Epub 2024 Apr 24. PMID: 38655818.

14. Tyagi S, Sadhu S, Sharma T, Paul A, Pandey M, Nain VK, Rathore DK, Chatterjee S, Awasthi A, Pandey AK. VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection. Front Immunol. 2024 Mar 7;15:1302163. doi: 10.3389/fimmu.2024.1302163. PMID: 38515752; PMCID: PMC10955575.7.

15. Sadhu S., Goswami S., Khatri R., Lohiya B., Singh V., Yadav R., Das V., Tripathy M.R., Dwivedi P., Srivastava M., Mani S., Awasthi A. 2024. Berbamine prevents SARS-CoV-2 entry and transmission. iScience. 2024 Nov. https://doi.org/10.1016/j.isci.2024.111347.

Dalal R, Sadhu S, Awasthi A, Role of Th17 cell in tissue inflammation and organ-specific autoimmunity. Translational Autoimmunity. Book chapter. 93-121(Equally Contributed).

1. A Patent “Novel Autophagy Inducing Peptides and Combinations thereof Composition and a process for Manufacturing the same”  (Application NO.202011007117-LIPC Ref No. IP0429).

2. A Patent “Novel cholic acid derivatives for the treatment and prevention of autoimmune diseases and uses thereof” Patent application No 202211005368 (Accepted).    

3. A Patent “A Bisbenzylisoquinoline alkaloids as a TLR4 agonist” patent Application No.  202411088715 (Indian patent filed).

1. A Patent “Novel Autophagy Inducing Peptides and Combinations thereof Composition and a process for Manufacturing the same” Application was filed (Application NO.202011007117-LIPC Ref No. IP0429).

2. A Patent “Novel cholic acid derivatives for the treatment and prevention of autoimmune diseases and uses thereof” Patent application No 202211005368 (Accepted).    

3. A Patent “A Bisbenzylisoquinoline alkaloids as a TLR4 agonist” patent Application No.  202411088715 (Indian patent filed).

1.      Best poster award (First prize) got in a poster presentation at THSTI foundation day on July 15th, 2019(Title: - Role of HIF1α in salmonella infection.)

2.      Best poster award (First prize) got in a poster presentation at “International Symposium on Infectious Diseases” from 12-14 November 2018 at Jamia Hamdard and THSTI, Delhi, NCR.

3.      Poster presented at IUIS-IIS-FIMSA international immunology course work program from 12-16th 2019 at Jaipur (FIMSA travel grant).

4.      Poster presented at 9th International symposium on autophagy from Nov 3-7 2019 at Taiwan. (THSTI grant).

5.      IUIS-FIMSA Travel grant 2023 to attend IUIS Conference (Cape Town, South Africa).

6.      Life member of Indian Immunology society.

7.      Member of organizing committee in world immunology day celebrations (2015) at THSTI.

8.      Member of volunteer committee in Immunocon-2018.

9.      G.P. Talwar young Scientist Award of Indian Immunology Society India in 2021.

10.   M.K Bhan best published paper Award from DBT-THSTI in 2021.

11.   Delivered a talk on “Impact of IL-9 on SARS-CoV-2 infection and lung Inflammation “at Global Immunology Summit-2024 at THSTI (Feb 15th-17th).

12.   Organised International “Global Immunology Summit-2024” at THSTI from Feb 15th-17th 2024.

13.   ICMR International travel grant to attend IUIS-2023 at Cape Town (3/2/TG-121/HRD-2023 (11).

14.   Indian immunology foundation International travel grant September 2023.

15.   M.K Bhan best published paper Award in faculty category from DBT-THSTI in 2024.

16.  FIMSA travel grant to attend the 9th FIMSA Immunology conference going to held at Taipei, Taiwan (Taipei International Convention Centre).

17.  Elected as an Executive Committee member (EC) of Indian Immunology Society (IIS) 2024-2026.

18. Received International Travel Grant from SERB to participate in FIMSA-2024 Congress held at Taipei, Taiwan from 23rd October 2024 to 27th October 2024.

19. IUIS Junior Community member.

20. IUIS-ITH (Immunotherapy) Committee early career representative member.

  • Abstracts published
  • Transcription factor Foxo1 directs the differentiation of IL-9+ T helper cells Abstract Submitted in FOCIS 2015 annual meeting (June24-27).
  • Transcription factor Foxo1 directs the differentiation of IL-9+ T helper cells Abstract Submitted in FIMSA 2015 (30 June- 3 July).
  • A role of Hypoxia-inducible factor-1α (HIF-1α) IN Salmonella infection. Abstract submitted in IMMUNOCON-2016 at Vishakhapatnam, A.P.
  • Novel Host Directed Intervention strategy against Salmonella infection in Macrophages Abstract submitted in 9th ISA at Taipei (Taiwan) November 2019.
  • HIF-1α plays an Important role in Salmonella Infection in Macrophages Abstract submitted in International Symposium on Infectious Diseases from 12-14 November 2018 at Jamia Hamdard and THSTI, Delhi, NCR.
  • Identification of Fangchinoline as a Toll-like receptor 4 agonist that induces anti-bacterial immunity. Srikanth Sadhu, Rajdeep Dalal, Yoshikazu Honda Okubo, Nikolai Petrovsky, Deepak Salunke, Amit Awasthi. Frontiers in Immunology (IUIS-2023).
  • Understand the SARS-CoV-2 infection-associated extra pulmonary pathologies and post COVID19 sequelae Jyotsna Dandotiya, Zaigham Abbas Rizvi, Srikanth Sadhu, Rajdeep Dalal, Amit Awasthi. Frontiers in Immunology (IUIS-2023).
  • Identification of Fangchinoline as a Toll-like receptor 4 agonist that indicates anti-bacterial immunity at IUIS-2023 at Cape Town.
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  • SRIKANTHSADHU[AT]THSTI[DOT]RES[DOT]IN