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Publication

1.      Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis. Rahul Pal, Sakshi Talwar, Manitosh Pandey, Vaibhav Nain, Taruna Sharma, Shaifali Tyagi, Vishawjeet Barik, Shweta Chaudhary, Sonu Kumar Gupta, Yashwant Kumar, Ranjan Nanda, Amit Singhal and Amit Kumar Pandey*. (2024). Tuberculosis (2024);45:102477.https://doi.org/10.1016/j.tube.2024.102477

2.      Biocompatible Human Placental Extracellular Matrix Derived Hydrogels. Sunil Gujjar, Anurag Tyagi, Saloni Sainger, Puja Bharti, Vaibhav Nain, Pratibha Sood, Prakash Jayabal, Jagadish Chandra Sharma, Priyanka Sharma, Sanjay Rajput, Anil Kumar Pandey, Amit Kumar Pandey, Prasad Abnave, Santosh Mathapati. Advanced Biology: 8;(1);Oct 2024. https://doi.org/10.1002/adbi.202300349

3.      VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection. Shaifali Tyagi, Srikanth Sadhu, Taruna Sharma, Abhijit Paul, Manitosh Pandey, Vaibhav Nain, Deepak Rathore, Samrat Chatterjee, Amit Awasthi*Amit Kumar Pandey*(2023)Frontiers in Immunology. 2024. In press

4.      Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection. Satish Tiwari, Mohammed Ahmad, Varun Kumar, Deepsikha Kar, Swati Kumari, Abhisek Dwivedy, Ravi Kant Pal, Amit Mohapatra, Vaibhav Kumar Nain, Vishawjeet Barik, Rahul Pal, Ranjan Nanda, Amit Kumar Pandey# & Bichitra Kumar Biswal#. (2023)BioRxiv 2023.06.20.545697; doi: https://doi.org/10.1101/2023.06.20.545697

5.      Transcription factor mce3R modulates antibiotics and disease persistence in Mycobacterium tuberculosis. Manitosh Pandey, Sakshi Talwar, Rahul Pal, Vaibhav Nain, Sonia Johri, Amit Singhal, Amit Kumar Pandey*(2023) Research in Microbiology. https://doi.org/10.1016/j.resmic.2023.104082

6.      Omicron sub-lineage BA. 5 infection results in attenuated pathology in hACE2 transgenic mice Zaigham Abbas Rizvi, Jyotsna Dandotiya, Srikanth Sadhu, Ritika Khatri, Janmejay Singh, Virendra Singh, Neeta Adhikari, Kritika Sharma, Vinayake Das, Amit Kumar Pandey, Bhabatosh Das, Guruprasad Medigeshi, Shalendra Mani, Shinjini Bhatnagar, Sweety Samal, Anil Kumar Pandey, Pramod Kumar Garg, Amit Awasthi. Commun Biol 6, 935 (2023). https://doi.org/10.1038/s42003-023-05263-6

7.      Investigating a putative transcriptional regulatory protein encoded by Rv1719 gene of Mycobacterium tuberculosis. Manitosh Pandey, Satish Tiwari, Sonia Johri, Bichitra K Biswal, Chandresh Sharma*Amit Kumar Pandey*. The Protein Journal (2022);41(3):424-433

8.      Low levels of Fe and Se with high IL-6/IL-10 likely influence nutritional immunity in tuberculosis patients. Sandeep R Kaushik, Sukanya Sahu, Hritusree Guha, Sourav Saha, Ranjit Das, Rukuwe-u Kupa, Wetetsho Kapfo, Trinayan Deka, Rumi Basumatary, Asunu Thong, Arunabha Dasgupta, Bidhan Goswami, Amit Kumar Pandey, Lahari Saikia, Vintosole Khamo, Anjan Das, Ranjan Nanda*Front Immunol. (2022);13:985538. doi: 10.3389/fimmu.2022.985538

9.      Novel genetic polymorphisms identified in the clinical isolate of Mycobacterium tuberculosis PE_PGRS33 gene modulates cytokines secretion and promotes in-vitro survival inside macrophages. Rahul Gupta, Manitosh Pandey, Amit Kumar Pandey, Pramod Kumar Tiwari* and Rabbind Singh Amrathlal*Journal of Infection and Public Health (2021). doi: https://doi.org/10.1016/j.jiph.2022.01.001

10.   Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection. Zaigham Abbas Rizvi, Rajdeep Dalal, Srikant Sadhu, Akshay Binayke, Jyotsna Dandotiya, Yashwant Kumar, Tripti Srivastava, Sonu Kumar Gupta, Suruchi Agarwal, Manas Ranjan Tripathy, Deepak Kumar Rathore, Amit Kumar Yadav, Guruprasad R. Medigeshi, Amit Kumar Pandey, Sweety Samal, Shailendra Asthana, Amit Awasthi*eLife (2022);11;e73522, doi: 7554/eLife.73522.

11.   Gefitinib results in robust host-directed immunity against Salmonella infection through proteo-metabolomic reprogramming. Srikanth Sadhu, Zaigham Abbas Rizvi, Ramendra Pati Pandey, Rajdeep Dalal, Deepak Kumar Rathore, Bhoj Kumar, Manitosh Pandey, Yashwant Kumar, Renu Goel, Tushar Kanti Maiti, Atul Kumar Johri, Ashutosh Tiwari, Amit Kumar Pandey, Amit Awasthi*Frontiers in Immunology (2021). 31 March 2021 https://doi.org/10.3389/fimmu.2021.648710.

12.   Reverse Zoonosis of coronavirus disease-19: Present status and the control by one health approach. R. Kumar Pramod, Asha V. Nair, Padmakar Kamalakar Tambare, Kanchana Chauhan, T. Vinay Kumar, R. Anju Rajan, Blessy M. Mani, Muhasin Asaf and Amit Kumar PandeyVeterinary World (2021), 14(10): 2817-2826. https://doi.org/10.14202/vetworld.2021.2817-2826

13.   Host cholesterol modulates the generation and enrichment of persister population during Mycobacterium tuberculosis infectionSakshi Talwar, Manitosh Pandey, Chandresh Sharma, Rintu Kutam, Josephine Lum, Daniel Carbajo, Renu Goel, Michael Poidinger, Debasis Dash, Amit Singhal and Amit Kumar Pandey*. mSystems (2020), Dec 2020, vol 5(6). https://doi.org/10.1128/mSystems.00855-20.

14.   Essential role of NIX in metabolic reprogramming for macrophage plasticity during mycobacterial species infection. Ranjeet Singh Mahla, Akhilesh Kumar, Helena Tutil, Sreevidhya Tarakkad Krishnaji, Bharathwaj Sathyamoorthy, Mahad Noursadeghi, Judith Breuer, Amit Kumar Pandey and Himanshu Kumar*. Tuberculosis (2021), Vol 126, https://doi.org/10.1016/j.tube.2020.102046

15.   Exploration of potential extra-ribosomal functions of Mtb RpsB in imparting stress resilience and drug tolerance in Mycobacteria. Chetan Prakash, Manitosh Pandey, Yatendra Singh, Saneev Kanojiya, Amit Kumar Pandey and Niti Kumar*. Biochimie (2020). Vol 177, Oct, Pages 87-97. https://doi.org/10.1016/j.biochi.2020.08.007

16.   Evaluation of in silico designed inhibitors targeting MelF (Rv1936) against Mycobacterium marinum within macrophages. Renu Dharra, Radhakrishnan VS, Tulika Prasad, Zoozeal Thakur, Jeffrey Cirillo, Amit Kumar Pandey, Mahesh Kulharia and Promod Mehta. Scientific Reports (2019) volume 9, Article number: 10084. https://www.nature.com/articles/s41598-019-46295-5

17.   Iron homeostasis in Mycobacterium tuberculosis is essential for persistence. Manitosh Pandey, Sakshi Talwar, Sutapa Bose and Amit Kumar Pandey*Scientific Reports (2018) volume 8, Article number: 17359. https://www.nature.com/articles/s41598-018-35012-3

18.   Diphenyleneiodonium chloride (DPIC) displays broad-spectrum bactericidal activity. Manitosh Pandey, Alok Kumar Singh, Ritesh Thakare, Sakshi Talwar, Pratiksha Karaulia, Arunava Dasgupta, Sidharth Chopra, and Amit Kumar Pandey*Scientific Reports (2017). volume 7, Article number: 11521. https://doi.org/10.1038/s41598-017-11575-5.

19.   Biological evaluation of Diphenyleneiodonium chloride (DPIC) as a potential drug candidate for treatment of non-tuberculous mycobacterial infections. Alok Kumar Singh, Pratiksha Karaulia, Ritesh Thakare, Swetarka Das, Manitosh Pandey, Amit Kumar Pandey, Sidharth Chopra and Arunava Dasgutpa*Journal of Antimicrobial Chemotherapy (2017). Volume 72, Issue 11, 1 Nov, Pages 3117–3121, https://doi.org/10.1093/jac/dkx277

20.   Rational design of drug-like compounds targeting Mycobacterium marinum MelF Protein. Rennu Dharra, Sakshi Talwar, Jeffery D. Cirillo, Amit Kumar Pandey, Mahesh Kulharia, and Parmod K. Mehta*PloS One (2017). https://doi.org/10.1371/journal.pone.0183060.

21.   Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial Phosphatase. Anshika Singhal, Gunjan Arora, Richa Virmani, Parijat Kundu, Tanya Khanna, Andaleeb Sajid, Richa Misra, Jayadev Joshi, Vikas Yadav, Sintu Samanta, Neeru Saini, Amit K. Pandey*, Sandhya S. Visweswariah, Christian Hentschker, Dorte Becher, Ulf Gerth* and Yogendra Singh*J Biol Chem. (2015) Oct 23;290(43):26218-34. doi: 10.1074/jbc. M115.687269. Epub 2015 Sep 8.

*co-corresponding authors

22.   Identification of Ser/Thr kinase and forkhead associated domains in Mycobacterium ulcerans: characterization of novel association between protein kinase Q and MupFHA. Gunjan Arora, Andaleeb Sajid, Anshika Singhal, Jayadev Joshi, Richa Virmani, Meetu Gupta, Nupur Verma, Abhijit Maji, Richa Misra, Gregory Baronian, Amit K. Pandey, Virginie Molle, Yogendra Singh. PLoS Negl Trop Dis. (2014) Nov 20;8(11):e3315. doi: 10.1371/journal.pntd.0003315. eCollection 2014 Nov.

23.   Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Jennifer E.Griffin*, Amit K. Pandey*, Sarah A. Gilmore, Valerie Mizrahi, John D. McKinney, Carolyn R. Bertozzi and Christopher M. Sassetti.Chemistry and Biology (2012) Feb: 24,19(2):218-27. *contributed equally to this work

24.   NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium Tuberculosis. Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti and Michelle A. Kelliher. PLoS Pathogen (2009), Jul;5(7):e1000500. Epub 2009 July3. 

25.   Increase NOD2-mediated recognition of N-glycolylated muramyl dipeptide. Francois Coulombe, Maziar Divangahi, Frederic Veyrier, James Gleason, Yibin Yang, Michelle A.Kelliher, Amit K. Pandey, Christopher M. Sassetti, Michael B. Reed and Marcel A. Behr. Journal of Expt. Med. (2009). Aug 3;206(8):1709-16. Epub 2009 Jul 6.

26.   Phthiocerol dimycocerosate (PDIM) transport is required for resisting IFN-γ-independent immunityJeffrey P. Murry, Amit K. Pandey, Christopher M. Sassetti, and Eric J. Rubin. 2009Journal of Infectious Diseases. (2009). Sep 1;200(5):774-82. 

27.   Role of Cholesterol in Mycobacterium tuberculosis infection. Maurine D Miner, Jennifer C Chang, Amit K Pandey, Christopher M Sassetti and David R Sherman. Indian Journal of Exp. Biol. (2009). June; 47: 407-11.

28.   igr genes and Mycobacterium tuberculosis cholesterol metabolism. Jennifer C Chang, Maurine D Miner, Amit K Pandey, Wendy P Gill, Nada S Harik, Christopher M  Sassetti and David R Sherman. J. Bacteriol. (2009). Aug;191(16):5232-9. 

29.   Nitrile-inducible gene expression in mycobacteria. Amit K. Pandey, Sahadevan Raman, Rose Proff, Swati Joshi, Choong-Min Kang, Eric J. Rubin, Robert N. Husson and Christopher M. Sassetti. Tuberculosis (Edinb) (2009).Jan;89(1):12-16

30.   Mycobacterial persistence requires the utilization of host cholesterol. Amit K. Pandey and Christopher M SassettiProc Natl Acad Sci. U S A (2008). March 18; 105(11):4376-80. http://www.pnas.org/content/105/11/4376.full.pdf+html

31.   NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. Yibin Yang, Catherine Yin, Amit Pandey, Derek Abbott, Christopher Sassetti and Michelle A. Kelliher. J. Biol. Chem.(2007) Dec 14; 282(50):36223-9. 

32.   Characterization of mycobacterial virulence genes through genetic interaction mapping. Swati Joshi, Amit K. Pandey, Nicole Capite, Sarah M. Fortune, Eric J. Rubin, and Christopher M. Sassetti. Proc Natl Acad Sci. U S A.(2006). Aug 1; 103(31):11760-5. 

33.   Identification of Mycobacterium marinum macrophage infection mutants. Parmod K. Mehta*, Amit K. Pandey*, Selvakumar Subbian, Mustapha M. Samarkandi, Suat L.G. Cirillo and Jeffery D. Cirillo. Microb Pathog.(2006). Apr;40(4):139-51. *contributed equally to this work.

Projects in the laboratory:

1.     We have identified novel pathways that regulate cholesterol mediated mycobacterial persistence and we are looking for highly motivated graduate students who are interested in understanding the biology of mycobacterial persistence. More specifically, the research focus will be to characterize and understand the roles of few identified Mtb genes in mycobacterial persistence.

2.     My lab will be interested in generating a carbon source independent in-vitro model of mycobacterial persistence. Briefly, since we have some preliminary understanding of how persisters are generated, we would like to utilize our understanding to rewire Mtb signaling by generating recombinant Mtb that mimic “persisters”. The strain thus generated would be characterized by identifying persister specific transcriptional and proteomic signatures. This model would than be used for screening antimicrobial compounds specifically targeting persisters.

3.     Since Mtb is an obligate intracellular pathogen, it has to adapt very quickly to intracellular niche and neutralize any host-mediated insults. We would also be interested in exploring the contribution of host in helping long-term survival of the pathogen inside the host. Briefly, the potential host targets genes will be knocked out by CRISPR and the role of specific host genes would be deciphered by analysing the growth of mycobacteria in these KO cell lines. 

  • Ramalingaswami Fellowship, 2010-11

  • ICAR-SRF Fellowship

  • ICAR JRF Fellowship

MR.VAIBHAV KUMAR NAIN
PH.D STUDENT

MS.TARUNA SHARMA
PH.D STUDENT

MR.VISHAWJEET BARIK
PH.D STUDENT

MS.ZOHRA HASHMI
PH.D STUDENT

MS.SAIMA PERWEEN
PH.D STUDENT

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