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DR.SIKANDER SAINI

Ph.D.

SCIENTIST D

  • Ph.D. in Animal Biotechnology (National Dairy Research Institute)

As a dedicated researcher in the field of Reproduction Biology, I specialize in Embryo Biotechnology, contributing to advancements in genetic resource preservation and application. My work plays a crucial role in maintaining genetic diversity and enhancing the availability of valuable rodent models for biomedical research. My lab is currently focusing on below mentioned areas.

Research Interests

Rodent Germplasm Cryopreservation:

My primary focus is on the development and optimization of cryopreservation techniques for rodent germplasm, which includes sperm, oocytes, and embryos. This work not aids in the long-term storage of genetic material, thereby strengthening breeding programs and uninterrupted biomedical research.

Mouse Genome Engineering:

I am passionate about employing cutting-edge genome engineering techniques to create genetically modified mouse models. These models are pivotal for elucidating gene function, unraveling disease mechanisms, and exploring potential therapeutic strategies. My research endeavors to improve the precision and efficiency of genome editing techniques, thereby enhancing the quality and reliability of animal models for experimental use.

Stem Cell Research:

My interests also encompass stem cell biology, particularly its applications within regenerative medicine and developmental biology. By integrating stem cell research with germplasm cryopreservation efforts, I aim to investigate innovative applications and therapeutic interventions that can lead to substantial advancements in our understanding of various diseases.

 

My lab's primary focus is to establish a robust repository of rodent germplasm, designed to be one of a kind in its comprehensiveness and utility. We are also committed to enhancing our comprehension of genetics and reproductive biology through rigorous research methodologies. I welcome opportunities for collaboration, discussion, and knowledge exchange within the field and beyond with fellow researchers.

Publication
  • Bhaskar, V., Saini, S., Ansari, S., Ghai, S., Thakur, A., Chopra, S., Verma, V. and Malakar, D., 2023. Allogenic adipose derived mesenchymal stem cells are effective than antibiotics in treating endometritis. Scientific Reports, 13(1), p.11280. (https://doi.org/10.1038/s41598-023-36820-y)
  • Ansari, S., Saini, S., Jamwal, S., Thakur, A., Kumar, A., Sehrawat, P., Devi, P. and Malakar, D., 2022. Stage specific gene expression of folate mediated one-carbon metabolism enzymes and transporters in buffalo oocytes and pre-implantation embryos. Gene Expression Patterns, 46, p.119282. (https://doi.org/10.1016/j.gep.2022.119282)
  • Dubey, A., Saini, S., Sharma, V., Malik, H., Kumar, D., De, A.K., Bhattacharya, D. and Malakar, D., 2022. Deducing Insulin-Producing Cells from Goat Adipose Tissue-Derived Mesenchymal Stem Cells. Cellular Reprogramming, 24(4), pp.195-203. (https://doi.org/10.1089/cell.2022.0029)  
  • Ghai, S., Saini, S., Ansari, S., Verma, V., Chopra, S., Sharma, V., Devi, P. and Malakar, D., 2022. Allogenic umbilical cord blood-mesenchymal stem cells are more effective than antibiotics in alleviating subclinical mastitis in dairy cows. Theriogenology, 187, 141-151.(https://doi.org/10.1016/j.theriogenology.2022.05.001)
  • Saini, S., Sharma, V., Ansari, S., Kumar, A., Thakur, A., Malik, H., Kumar, S. and Malakar, D. 2022. Folate supplementation during oocyte maturation positively impacts the folate-methionine metabolism in pre-implantation embryos. Theriogenology, 182, 63-70. (https://doi.org/10.1016/j.theriogenology.2022.01.024)
  • Saini, S., Ansari, S., Sharma, V., Saugandhika, S., Kumar, S. and Malakar, D. 2022. Folate receptor- 1 is vital for developmental competence of goat embryos. Reproduction in Domestic Animals, 00, 1– 9. (https://doi.org/10.1111/rda.14092)
  • Malik, H.N., Singhal, D.K., Saini, S.and Malakar, D., 2020. Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat. Scientific reports, 10(1), 1-14. (https://doi.org/10.1038/s41598-020-66609-2)
  • S Saugandhika, V Sharma, H Malik, S Saini, S Bag, S Kumar, NK Singh, AK Mohanty, D Malakar. 2015. Expression and purification of buffalo intereferon-tau and efficacy of recombinant buffalo interferon-tau for in vitro embryo development. Cytokine. 75(1), 186-96.(https://doi.org/10.1016/j.cyto.2015.03.012)
  • Sikander Saini, Vishal Sharma and Dhruba Malakar*, 2022. Stem Cells: A promising regenerative medicine therapy for treatment of diseases of animals. In Sustainable Livestock Production for Livelihood Improvement (pp. 141-153). International books & periodicals supply service (ISBN: 9789390425402)
  • Malakar, D., Malik, H.N., Kumar, D., Saini, S., Sharma, V., Fatima, S., Bajwa, K.K. and Kumar, S., 2021. Stem cells: a potential regenerative medicine for treatment of diseases. In Advances in Animal Genomics (pp. 33-48). Academic Press (ISBN: 978-0-12820595-2).
  • Shama Ansari, Sikander Saini, Vishal Sharma, Dhruba Malakar. Dec-Jan, 2019-2020. Fasting promotes longevity through autophagy. Everyman’s Science. Vol. LIV(5): 303-307 (ISSN: 0531-495X).
  • V Sharma, A Thakur, A Kumar, B Shama, B Aneja, S Saini, D Malakar. Conservation of germplasm and stem cells in livestock and their applications in future. 2017. In situ conservation of Indigenous livestock and poultry breeds. Ch. 21 pp 159-71. (ISBN:978-93-83537-37-2).
  • D Malakar,V Sharma, S Saini. Stem Cells: A Solution for Male and Female Infertility. 2016. Genetic Evaluation and Multiplication of Superior Germplasm for Genetic Improvement in Livestock. Ch 32 pp 269-279.
  • D Malakar,S Saini,V Sharma, H Malik. Production of mesenchymal stem cells for regenerative tissue therapy in livestock. 2016. Advances in Reproductive Biotechnology. pp 102-112.
  • V Sharma, S Saini, D Malakar. Oct-Nov, 2016. Environmental threats posed by Genetically Engineered Vaccines. Everyman’s Science. Vol. LI(4):213-216. (ISSN: 0531-495X).
  • विशाल शर्मा, सिकंदर à¤¸à¥ˆà¤¨à¥€ à¤à¤µà¤‚ ध्रुबा मालाकार. स्टेम कोशिकायें और उनके उपयोग. 2016-2017. दुग्ध à¤—ंगा. NDRI, Karnal
  • D Malakar, V Sharma, S Saini. Characterisation of Embryonic and Adult Stem Cells. 2014. National Training on Stem Cell Technology in Farm Animals. Ch 2 pp 26-38.
  • V Sharma, S Saini, H Malik, DK Singhal, D Malakar. Generation of stem cells and their application. 2013. Advanced breeding and allied technologies for enhancing livestock productivity. Ch 29 pp 230-247.
  • SIKANDERSAINI[AT]THSTI[DOT]RES[DOT]IN