• ट्रांसलेशनल हेल्थ साइंस एंड टेक्नोलॉजी इंस्टीट्यूट
  • TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE
    AN INSTITUTE OF BIOTECHNOLOGY RESEARCH AND INNOVATION COUNCIL
    DEPT. OF BIOTECHNOLOGY, MINISTRY OF SCIENCE AND TECHNOLOGY
    GOVT OF INDIA
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Publication

2025-26

1.  Goswami Y, Baghel A, Sharma G, Sharma PK, Biswas S, Yadav R, Garg PK, Shalimar, Tandon R*. Liver organoids from hepatocytes of healthy humans and non-alcoholic fatty liver disease (NAFLD) patients display multi-lineage architecture and can be used to develop an in vitro model of steatohepatitis Journal of Clinical and Experimental Hepatology, (2025);15(3):102463. (*Corresponding Author)

2. Kamala MRP, Reddy PN1, Goswami Y, Dwivedi W, Pujani M, Dikshit M, Tandon R.* AYUSH-64 Modulates Th17/Treg Balance to Attenuate LPS-Induced Inflammation in Cell-based Assays and BALB/c Mice Model. Pharmacological Research-Natural Products, Vol 6(100159) (2025)https://doi.org/10.1016/j.prenap.2025.100159(*Corresponding Author)

3. Dhavaria, S., Maram, K., Priya, M.R.K., Tandon R*, Dhiman M A Greener and Scalable Approach for the Synthesis of MRT67307 and Its AntiInflammatory Activity. Russ J Gen Chem95, 1048–1056 (2025). https://doi.org/10.1134/S1070363224613474 (*Corresponding Author)

4. Reddy PN, Singh D, Tandon R. Applications of Nanocomposites for 3d and 4d Printing of Nanomaterials in Biomedical Research, Apple Academic Press (2025) Biomedical Engineering and Nanotechnology https://www.appleacademicpress.com/nanocomposites-and-nanomaterials-in-biomedical-applications-/9781779641229 In: Dave V, Singh D, Reddy PN (eds)

 

2024-25:

1. Goyal C, Tandon R*. USP30 Inhibitors and Mitophagy, a Cellular Power Couple against Metabolic-Associated Fatty Liver Disease, Advances in Pharmacology & Clinical Trials,(2024) 9(3) ISSN:2474-9214. DOI: 10.23880/apct-16000248 (*Corresponding Author)

2. Tandon, R*., Kumar, P. Artificial Intelligence and Machine Learning for Exploring PROTAC in Underutilized Cells. In: Nandave, M., Jain, P. (eds) PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics. Springer,  Singapore (2024). https://link.springer.com/chapter/10.1007/978-981-97-5077-1_14  (*Corresponding Author)

 

2023-2024:

1. Sharma PK, Verma L, Goswami Y, Pujani M, Dikshit M*, Tandon R* The aqueous root extract of Withania somnifera ameliorates LPS-induced inflammatory changes in the in vitro cell-based and mice models of inflammation Front. Pharmacol., (2023)14:1139654. doi: 10.3389/fphar.2023.1139654 (*Corresponding Author)

2. Kumari D, Gautam J, Sharma V, Gupta S, Sarkar S, Jana P, Singhal V, Babele P, Kamboj P,  Bajpai S, Tandon R, Kumar Y, Dikshit M. Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice, HELIYON (2023), doi:       https:// doi.org/10.1016/j.heliyon.2023.e22051.

 

2022-2023:

1. Soni A, Saha S, Agarwal A, Rauf ARA, Singh RK, Seth M,   Singh SK, Sinha S, Shirumalla RK, Marumoto S, Tandon R* 2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamides analogs as potential antagonists of Urotensin-II receptor,  J Recep Sig Trans, (2023);43(1):1-8. doi: 10.1080/10799893.2022.2164306. (*Corresponding Author).

2.  Visaga SA,  Kalonia H,  Verma V,  Sinha S,  Singh SK,  Upadhyay S, Sahdev S,  Pansari P,  Kumar R,  Bandgar M, Karanjule N, Shirumalla RK,  Morishita K, Tandon   RDeveloping selective FPR2 agonists can be a potential approach to treat moderate to severe asthma(2022) J Clin Toxicol, Vol.12 (3)1000510 (*Corresponding Author)

3. Sharma P, Nandave M, Nandave D, Yadav S, De-Le_Cruz CV, Singh S, Tandon R, Ramniwas S, Behl T. Reactive oxygen species(ROS)-mediated oxidative stress in chronic liver diseases and its mitigation by medicinal plants. Am J Trans Research. (2023), 15(10).

 

2021-2022

1.  Singh RK, Sodhi R, Sharma S, Dastidar SG, Tandon R*. Targeting MAPAKAP2(MK2) to combat inflammation by avoiding the differential regulation of anti-inflammatory genes by p38 MAPK inhibitors. BioRxiv doi:https://doi.org/10.1101/2022.07.17.500377 2022 (*Corresponding Author)

 

2020 and earlier

§ Tandon R*, Soni A., Singh R.K., Sodhi R., Seth MK.,  Sinha S., Dhage G., Das B., Dastidar SG, Shriumalla RK. Marumoto S, Nagayama T. Identification of novel Urotensin-II receptor antagonists with potent inhibition of U-II induced pressor response in mice (2020) Euro J Pharmacol  886:173391.DOI: 10.1016/j.ejphar.2020.173391, PMID: 32745605 (*Corresponding Author)

§ Soni A, Agarwal A, Saha S, Shripati KR, Das M, Das B, Cliffe I, Tandon R, Singh RK, Dastidar S, Singh SK, Sinha S, Shriumalla RK, Semwal VP, Marumoto S, Nagayama T. Design, synthesis, and SAR of 2-acetamido-3-pyrrolidinepropanamide derivatives as Urotensin-II receptor antagonists, 250th American Chem Soc.  National Meetings and Expositions, Boston, MA, USA, 2015

§  Tandon R*, Senthil V., Nithya D., Venkataramanan R.,  Pamidiboina V., Kumar A, Malik S, Chaira T, Diwan M, Gupta P, Venkataramanan R, Malik R, Das B, Dastidar SG, Cliffe IA; Ray A; Bhatnagar PK. RBx10080307, a dual EGFR/IGF-1R inhibitor for anticancer therapy (2013) Euro J Pharmacol 711(1-3):19-26. DOI: 10.1016/j.ejphar.2013.04.016PMID: 23639757(*First and Corresponding Author)

§  Singh RK, Tandon R, Dastidar SG, Ray A. A review on leukotrienes and their receptors with reference to asthma (2013) J Asthma 50(9):922 931.    DOI: 10.3109/02770903.2013.823447PMID: 23859232 

§  Tandon R*, Kapoor S, Vali S, Senthil V., Nithya D., Venkataramanan R, Sharma A, Talwadkar A, Ray A, Bhatnagar PK and Dastidar SG. Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: A novel approach for overcoming resistance in anticancer treatment (2011) Euro  J Pharmacol 667(1-3):5665. DOI: 10.1016/j.ejphar.2011.04.066  PMID: 21640718  (*First and Corresponding Author)

§ Tiwari P, Saini S,  Upmanyu S, Benjamin B,  Tandon R, Saini KS and Sahdev S. Enhanced expression of recombinant proteins utilizing a modified baculovirus expression vector.(2010) Mol  Biotechnology 46(1):80-9.  DOI: 10.1007/s12033-010-9284-3 PMID: 20424933

§  Tandon R, Singh MP, Haq W, Dixit M, Patnaik GK and Dhar MM (2010) Design and synthesis of novel tetrapeptides as potential ACE inhibitors.Cheminformatics 28, 40.(*First Author)

§  Subhadra LB,  Sundaresan S,  Singaravelu A,  Kadapakkam SN,  Badri NR, Katiyar C,  Kanaujia  A, Duggar R, Singh Y,  Konasubrahmanya S,  Bansal V, Sarin S,  Tandon   R,  Sharma S and Singh S. (2009) Cinnamic acid isolated from the bark of Cinnamomum cassia regulates glucose transport through activation of glucose transporter 4 on L6 myotubes in a PI3 Kinase independent fashion. J Diabetes 1, 99-106. DOI: 10.1111/j.1753-0407.2009.00022.xPMID: 20929506

§  Soni A, Agarwal A, Saha S, Das M, Shripati K, Aeron S, Das B, Cliffe I, Tandon R, Singh R, Sodhi R. Design, synthesis, and SAR of 2-acetamido-3-pyrrolidinepropanamide derivatives as urotensin-II receptor antagonists. Abstracts of the papers of the American Chemical Society 2015 Aug 16 (Vol. 250). 1155 16TH ST, NW, Washington, DC 20036 USA: AMER CHEMICAL SOC.

§ Tandon R*, Gupta A, Ray A (2013)  Mechanism of action of antidiabetic property of cinnamic acid, a principal active ingredient from the bark of Cinnamomum cassiaInt J Therap Appls, 9, 2013, 39-45.  (*Corresponding Author)

§ Zhang M, Deng Y, Tandon R, Bai C, Riedel H. ( 2008) Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses J Cell Biochem, 1;103(1):162-81. DOI: 10.1002/jcb.21397PMID: 17615553

§ Sarma PK, Tandon R, Gupta P, Dastidar SG, Ray A, Das B, Cliffe IA(2007) Progress in the development of small molecule inhibitors of insulin-like growth factor-1 receptor kinase. Exp Opin Ther Pat 17(1) 25-35 (11) https://doi.org/10.1517/13543776.17.1.25

§ Mittra S, Sangle G, Tandon R, Sharma S, Roy S, Khanna V, Gupta A, Sattigeri J, Sharma L,  Khattar SK, Bora RS, Saini KS, Bansal VS (2007) Increase in weight induced by muraglitazar, a dual PPAR alpha/gamma agonist, in db/db mice: adipogenesis/or oedema? Br J Pharmacol, 150(4):480-7.  DOI: 10.1038/sj.bjp.0707000 PMID: 17211457

§  Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H.(2003) Growth factor receptor binding protein 10 (Grb10) as a partner of PI 3kinase in metabolic insulin action. J Biol Chem; 278(41):39311-22.   DOI: 10.1074/jbc.M304599200PMID: 12783867 

§  Singh SB*, Tandon R*, Krishnamurthy G, Vikram R, Sharma N, Basu SK and Mukhopadhyay A (2003) Rab5-mediated   endosome-endosome fusion.  Regulates.  hemoglobin endocytosis in Leishmania donovani. EMBO J; 22(21):5712-22.   DOI: 10.1093/emboj/cdg557PMID: 14592970 (*Co-first Author)

§  Narayan P, Pandey R, Yadav VS, Tandon R, Haq W, Dhar MM, Singh VK (2003). Inhibition of anti-CD3 and interleukin-2 stimulated T lymphocyte proliferation.  by peptidomimetic opioid compound. Immunopharmacol Immmunotox;25(2):225-33. DOI: 10.1081/iph-120020472  PMID: 12784915

§ Narayan P, Tandon R, Haq W, Dhar and MM Singh VK (2002) Inhibition of antigen-specific lymphocyte proliferation and cytokine stimulation by peptidomimetic opioid compound. Int Immunopharmacol 2:751-757. DOI: 10.1016/s1567-5769(02)00011-5PMID: 12095165

§ Narayan P, Singh VK, Agarwal SS, Tandon R, Haq W, Raghubir R and Dhar MM (2001) Immunomodulation by Opioid Peptidomimetic   Compound. Neuroimmunomodulation 9:134-40.   doi: 10.1159/000049017. PMID: 11752886

§  Sengupta S, Tripathi J, Tandon R, Roy RP, Basu SK and Mukhopadhyay A (1999) Hemoglobin endocytosis in Leishmania is mediated through a 46 kD protein located in flagellar pocket. J Bio Chem  274(5), 2758-2765.  DOI: 10.1074/jbc.274.5.2758PMID: 9915807

§ Tandon R, Singh MP, Haq W, Dikshit' M, Patnaik  GK, Dhar MM (1997), Synthesis of novel tetrapeptides as potential ACE inhibitors. I J Chem, 36B.(First Author)

§  Yousaf N, Deng Y, Tandon R, Cheng DW, Kang Y and Riedel H  (2001). Mus musculus Pro-rich, PH and SH2 domain-containing signaling mediator alpha mRNA, complete cds, alternatively spliced. NCBI GenBank; Accession number AF421138.

§  Yousaf  N, Deng Y, Tandon R, Cheng DW, Kang Y and Riedel H (2001). Mus musculus Pro-rich, PH and SH2 domain-containing signaling mediator gamma mRNA,   complete cds, alternatively spliced. NCBI GenBank Accession number AF421139.

§  Yousaf N, Deng Y, Tandon R, Cheng DW, Kang Y and Riedel H(2001). Mus musculus PSM/SH2-B delta (Sh2B psm1) mRNA, complete cds. NCBI GenBank Accession   number AF380422.

  1. Pallerla Naveen Reddy, Deependra Singh, Vivek Dave, and Ruchi Tandon.  Applications of Nanocomposites for 3d and 4d Printing of Nanomaterials in Biomedical Research. Apple Academic Press, Nanocomposites and Nanomaterials in Biomedical Applications, Edi: Vivek Dave, Deependra Singh, Pallerla Naveen Reddy.
  2.   Tandon, R*, Kumar, P. Artificial Intelligence and Machine Learning for Exploring PROTAC in Underutilized Cells. In: Nandave, M., Jain, P. (eds) PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics. Springer Nature,  Singapore (2024). https://link.springer.com/chapter/10.1007/978-981-97-5077-1_14  (*Corresponding author).

 

  1. Liver Organoid model using healthy persons and NAFLD patient-derived hepatocytes to overcome the challenges of preclinical screening for steatohepatitis. Investigators:     Ruchi Tandon, Yamini Goswami, Akash Baghel. New provisional Patent Application (Application no. 202411081650). Issued by Indian Patent Office.
  2. Novel formulations containing gut microbiota derived metabolites of dietary Tryptophan for the management of Non-alcoholic Fatty Liver Disease. Investigators: Ruchi Tandon, Phulwanti Kumari Sharma, Yamini Goswami, Ruby Bansal. Patent Application (Application no. 202311016126).
  3. Filed a patent on Imidazopyridine class of compounds as kinase inhibitors (2009) Ranbaxy Res Labs.
  4. Heat shock protein inducers in myocardial and cerebral ischemia. (2004) Torrent Pharmaceuticals ltd. Gujarat, ndia, Pct File No. Pct/in05/00112, Indian Patent File No. 178/kol/2004.
  5. 2-propene-1-ones as hsp 70 inducers, Torrent Pharmaceuticals Ltd. Gujarat, India, (International Patent Application number CA2562130C).
  6. An improved process for the preparation of polypeptide useful as a Gonadotropin-Releasing Hormone agonist having C-Terminal Proline ethyl amide". Central Drug Research Institute, Lucknow, India (Patent application No.3069/DEL/97).

¨     Appointed as Finance Secretary (Treasurer) International Academy of Cardiovascular Sciences (IACS), 2025

¨     Appointed as the Editorial Board member of CV Network, the official bulletin of the International Academy of Cardiovascular Sciences(IACS), 2025

¨     Appointed as Member, Editorial Board: Molecular and Cellular Biochemistry, 2025

¨     Appointed as Member, Editorial Board: Scripta Medica, 2025

¨     Appointed as Review Editor on the Editorial Board of Frontiers Journals., 2022

¨     Assistant Director and Group Head, Pharmacology, Daiichi Sankyo Pharma, 2012

¨     Assistant Director, Daiichi Sankyo Pharma, 2010

¨     Star Team award, Daiichi Sankyo, 2012

¨     SMART Team award, Daiichi Sankyo, 2013

¨     Individual Excellence Award, Ranbaxy Research Labs, 2006

¨     Postdoctoral Research Associate, Wayne State University, MI, USA (NIH, Bethesda, USA Fellowship) 2000

¨     International Travel Award: Research Centre for Biotechnology, Braunschweig, Germany, 1999

¨     CSIR Fellowship 1997  

¨     Reviewer international peer reviewed journals; PLOS One, Oncology Rev and Frontiers in Pharmacology, Biomedicine and Pharmacotherapy, Molecular and Cellular Biochemistry, Life Sciences, European J Pharmacology

.. Invited Speaker, Drug Discovery: National and International Symposia

 

 

Recent Invited Talks delivered in National and International Conferences

October 10-11 2025 

Delivered a talk entitled “Harnessing the potential of  human liver organoid developed from cells isolated from healthy individuals and patients to develop therapeutics and precision medicines against non-alcoholic fatty liver disease.” in the 10th Annual Cell and Gene Therapy Symposium, Centre for Stem Cell Research (a unit of inStem, Bengaluru), Christian Medical College Cam pus, Vellore, October 10-11, 2025.

 

Aug 25-26, 2025

Delivered a talk  entitled .“Decoding Innate Immune Mechanisms in Metabolic-Dysfunction Associated Steatotic Liver Disease(MASLD): Insights from Patients and Precision Mouse Models”. In the International Conference on "Recent Advances in Molecular and Translational Research in MASLD", held on 25–26 August 2025 at DPSRU, New Delhi.

 

Jun 10, 2025
Delivered an expert talk on “Leveraging human liver organoid model to develop therapeutics against Non-Alcoholic Fatty Liver Disease (NAFLD) on 10th June 2025 at Delhi Pharmaceutical Sciences and Research University (DPSRU).

 

Feb 10-12, 2025 

Delivered a talk on "Leveraging Tumour Organoid Models for Translational Research in Cancer" and received the Certificate of excellence by the  Nobel Laureate by  Prof. James Allison in the International conference '4th World Congress on Translational Cancer Research & Immunotherapy [WCTCRI] 2025" during Feb 10-12, 2025 at Mahatma Gandhi University of Medical Sciences and Technology, Jaipur organized by Prof. Anil Suri, Director of the Center for Cancer Immunotherapy. (Nobel Laureate Prof. James Allison,  received the Nobel Prize in Physiology and Medicine in 2018 for his pioneering discovery of CTLA4 and its inhibition as a potential anti-cancer therapy by inhibition of negative immune regulation.) 

 

Feb 1-2, 2025

 

Served as a Faculty and delivered a Keynote lecture on the topic titled, “Challenges and potential of Organoids in NAFLD and Heart Failure” during the Heart Failure Conflux 2025 organized by Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum. Kerala, India, Heart Failure Association of India, ICMR Centre for Advanced Research and Excellence in Heart Failure– SCTIMST, Trivandrum and International Academy of Cardiovascular Sciences on the Theme of Targeted Therapies in Heart Failure, held on 1st and 2nd February 2025.

Jan 10-12, 2025

Joint International Conference 2025, hosted by the esteemed International Academy of Cardiovascular Sciences, in Ahmedabad from January 10-12, 2025 and delivered a talk on "The Pharmacological Perspective Behind the Association Between Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk."

 

Membership of Societies

¨     Member, Editorial Board: Molecular and Cellular Biochemistry

¨     Member, Editorial Board: Scripta Medica

¨     Review Editor on the Editorial Board of Frontiers Journals

¨     Life Member, International Academy of Cardiovascular Sciences (IACS)

¨     Life Member, Indian Pharmacological Society (IPS)

¨     Life Member, Indian Society for Chemists and Biologists (ISCB)

¨     Member, Indian National Association for the Study of the Liver (INASL)

¨     Life Member, Research Society for the Study of Diabetes in India (RSSDI)

¨     Life Member, Indian Immunology Society (IIS)

Transfer of Technology 

¨     Developed a rapid and economic procedure for the synthesis of an LHRH agonist, Leuprolide, as an anti-prostate cancer drug for CIPLA Ltd.,               Mumbai, India. 

-    Synthesis of active peptide epitopes of proteins of biological significance for TATA Memorial Hospital, Mumbai.

 

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