English हिंदी
  • भारत सरकार के विज्ञान एवम प्रौदयोगिकी मंत्रालय के जैव प्रौदयोगिकी विभाग की स्वायत्त संस्थान
  • AN AUTONOMOUS INSTITUTE OF DEPT. OF BIOTECHNOLOGY, MINISTRY OF SCIENCE AND TECHNOLOGY, GOVT OF INDIA
  • होम
  • संकाय प्रोफ़ाइल

DR.SHAILENDRA MANI

PhD

SENIOR RESEARCH SCIENTIST

  • Post-doctoral fellow, Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
  • PhD, International Centre For Genetic Engineering And Biotechnology, New Delhi
  • MSc, School of Life Sciences, Jawaharlal Nehru University, New Delhi
  • BSc, Department of Zoology, Banaras Hindu University, Varanasi.

Our research focuses on studying the cross-reactivity and co-infection of SARS-CoV-2 with other coronaviruses and endemic viruses such as Dengue and influenza. Our ultimate objective is to gain insights into the interplay between these viruses during co-infection and their impact on the immune response. Additionally, we aim to explore the potential occurrence of Antibody Dependent Enhancement (ADE) in the context of coronaviruses and/or other endemic viruses. By deepening our understanding of these phenomena, we aim to develop effective vaccines and antiviral treatments for SARS-CoV-2, while also shedding light on the varying severity of viral infections among individuals. 

Our Research focuses in three key areas

1- SARS-CoV2 pandemic preparedness: resource generation for aiding rapid vaccine and antiviral development

As SARS-CoV2 virus pandemic hit India, we urgently required virus based serological assays to be established. Due to requirement of higher containment facility for virus culture, it was restricted to few institutions in India. At THSTI, we successfully established SARS-CoV2 virus culture and viral neutralization assays (cytopathic effect based). We continuously isolate newer circulating variant of SARS-CoV-2 in India and establish variant specific virus neutralization assay. We also provide our expertise to evaluate vaccine and antiviral candidates developed in India.

2- Development of tools to aid public health measures

We have developed a multiplex bead-based platform for detecting coronavirus infection from the serum samples. We next expanding our panel to detect arbovirus/endemic viral infection like Dengue, Zika, Japanese Encephalitis, West Nile, Chikungunya. For vaccine evaluation, we are developing antibody detection platform in multiplex format for Measles, Rubella, Diphtheria and Pertussis. The developed assays will be utilized for large scale community screening, screening for the potential plasma donors, and evaluating the efficacy of the future vaccine and antiviral candidate trials.

3- Understanding the pathogenies and immune response of coronaviruses

For a good coronavirus vaccine deployment, it is very crucial to check/know the sero-prevalence of the other circulating corona virus in the region. Till date 7 coronaviruses are known to infect human including 229E-hCoV, OC43-hCoV, NL63-hCoV, HKU1-hCoV, MERS-CoV, SARS-CoV and SARS-CoV-2. Serological evidences confirmed the presence of 229E-hCoV, OC43-hCoV, NL63-hCoV and HKU1-hCoV in Indian region. The current pandemic virus is circulating in regions where prevalence of the common coronaviruses is very high. Since they are closely related, we want to explore how the other coronaviruses influences the SARS-CoV-2 growth and replication kinetics during co-infections. A better understanding of these phenomena will help to prepare suitable vaccine candidates for SARS-CoV-2 and might explain differential viral severity in individuals.

Publication
  1. Zaigham Abbas Rizvi, Upasna Madan, Manas Ranjan Tripathy, Sandeep Goswami, Shailendra Mani, Amit Awasthi, Madhu Dikshit. Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris. Pharmaceuticals (Basel). 2023 Sep 21;16(9):1333 https://pubmed.ncbi.nlm.nih.gov/37765142/
  2. Zaigham Abbas Rizvi, Jyotsna Dandotiya, Srikanth Sadhu, Ritika Khatri, Janmejay Singh, Virendra Singh, Neeta Adhikari, Kritika Sharma, Vinayake Das, Amit Kumar Pandey, Bhabatosh Das, Guruprasad Medigeshi, Shailendra Mani, Shinjini Bhatnagar, Sweety Samal, Anil Kumar Pandey, Pramod Kumar Garg, Amit Awasthi. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice. Commun Biol. 2023 Sep 13;6(1):935. https://pubmed.ncbi.nlm.nih.gov/37704701/
  3. Shailendra Mani, Anupamjeet Kaur, Kamini Jakhar, Geetika Kumari, Sudipta Sonar, Amit Kumar, Sudesna Das, Santosh Kumar, Vijay Kumar, Rakesh Kundu, Anil Kumar Pandey, Umesh Prasad Singh, Tanmay Majumdar. Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections. Int J Biol Macromol. 2023 Aug 1:245:125444. https://pubmed.ncbi.nlm.nih.gov/37385308/
  4. Gaurav Batra, Deepika Rathna Murugesan, Sreevatsan Raghavan, Souvick Chattopadhyay, Farha Mehdi, Ayushi, Mudita Gosain, Savita Singh, Soon Jyoti Das, Suprit Deshpande, Sudipta Sonar, Kamini Jakhar, Jayanta Bhattacharya, Shailendra Mani, Anil Kumar Pandey, Sankalp, Shweta Goswami, Asim Das, Tanima Dwivedi, Nandini Sharma, Suresh Kumar, Pragya Sharma, Seema Kapoor, Pallavi Kshetrapal, Nitya Wadhwa, Ramachandran Thiruvengadam, Rakesh Kumar, Ritu Gupta, Pramod Kumar Garg, Shinjini Bhatnagar. Trends of humoral immune responses to heterologous antigenic exposure due to vaccination & omicron SARS-CoV-2 infection: Implications for boosting. Indian J Med Res. 2023 Jun;157(6):509-518. https://pubmed.ncbi.nlm.nih.gov/37322634/
  5. Shabnam Ansari, Nidhi Gupta, Rohit Verma, Oinam N Singh, Jyoti Gupta, Amit Kumar, Mukesh Kumar Yadav, Akshay Binayke, Mahima Tiwari, Neha Periwal, Vikas Sood, Shailendra Mani, Amit Awasthi, Shalimar, Baibaswata Nayak, CT Ranjith-Kumar, Milan Surjit. Antiviral activity of the human endogenous retrovirus-R envelope protein against SARS-CoV-2. EMBO Reports (2023)Volume 24 Issue 7. https://www.embopress.org/doi/epdf/10.15252/embr.202255900
  6. Zaigham Abbas Rizvi, Prabhakar Babele, Upasna Madan, Srikanth Sadhu, Manas Ranjan Tripathy, Sandeep Goswami, Shailendra Mani, Madhu Dikshit, Amit Awasthi. Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions. Front Immunol. 2023 Mar 7:14:1138215. https://pubmed.ncbi.nlm.nih.gov/36960064/
  7. Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi, Tripti Shrivastava, Sachin Kushwaha, Janmejay Singh, Praveenkumar Murugavelu, Anbalagan Anantharaj, Farha Mehdi, Nisha Raj, Shivam Singh, Jyotsna Dandotiya, Asha Lukose, Deepti Jamwal, Sandeep Kumar, Adarsh K Chiranjivi, Samridhi Dhyani, Nitesh Mishra, Sanjeev Kumar, Kamini Jakhar, Sudipta Sonar, Anil Kumar Panchal, Manas Ranjan Tripathy, Shirlie Roy Chowdhury, Shubbir Ahmed, Sweety Samal, Shailendra Mani, Sankar Bhattacharyya, Supratik Das, Subrata Sinha, Kalpana Luthra, Gaurav Batra, Devinder Sehgal, Guruprasad R Medigeshi, Chandresh Sharma, Amit Awasthi, Pramod Kumar Garg, Deepak T Nair, Rajesh Kumar. A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern. PLoS Pathog. 2022 Dec 12;18(12):e1010994. https://pubmed.ncbi.nlm.nih.gov/36508467/
  8. Akshay Binayke, Aymaan Zaheer, Jyotsna Dandotiya, Sonu Kumar Gupta, Shailendra Mani, Manas Ranjan Tripathy, Upasna Madan, Tripti Shrivastava, Yashwant Kumar, Anil Kumar Pandey, Deepak Kumar Rathore, Amit Awasthi. Proinflammatory Innate Cytokines and Distinct Metabolomic Signatures Shape the T Cell Response in Active COVID-19. Vaccines (Basel). 2022 Oct 20;10(10):1762. https://pubmed.ncbi.nlm.nih.gov/36298628/
  9. Zaigham Abbas Rizvi, Prabhakar Babele, Srikanth Sadhu, Upasna Madan, Manas Ranjan Tripathy, Sandeep Goswami, Shailendra Mani, Sachin Kumar, Amit Awasthi, Madhu Dikshit. Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. Front Immunol. 2022 Sep 27:13:945583. https://pubmed.ncbi.nlm.nih.gov/36238303/
  10. Sonal Garg, Nisha Raj, Asha Lukose, Deepti Jamwal, Hilal Ahmed Parray, Sandeep Kumar, Samridhi Dhyani, Kamini Jakhar, Sudipta Sonar, Mahima Tiwari, Reema, Shailendra Mani, Sankar Bhattacharyya, Chandresh Sharma, Tripti Shrivastava, Rajesh Kumar. Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2. 3 Biotech, 2022 Sep;12(9):202.  https://pubmed.ncbi.nlm.nih.gov/35928502/    
  11. Nitin Hingankar, Suprit Deshpande, Payel Das, Zaigham Abbas Rizvi, Constantinos Kurt Wibmer, Poppy Mashilo, Mohammed Yousuf Ansari, Alison Burns, Shawn Barman, Fangzhu Zhao, Sohini Mukherjee, Jonathan L. Torres, Souvick Chattopadhyay, Farha Mehdi, Jyoti Sutar, Deepak Kumar Rathore, Kamal Pargai, Janmejay Singh, Sudipta Sonar, Kamini Jakhar, Jyotsna Dandotiya, Sankar Bhattacharyya, Shailendra Mani, Sweety Samal, Savita Singh, Pallavi Kshetrapal, Ramachandran Thiruvengadam, Gaurav Batra, Guruprasad Medigeshi, Andrew B. Ward, Shinjini Bhatnagar, Amit Awasthi, Devin Sok, Jayanta Bhattacharya. A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. PLoS Pathog. 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089897/
  12. Ritika Khatri, Hilal Ahmad Parray, Ashish Kumar Agrahari, Zaigham Abbas Rizvi, Rachel Kaul, Sneha Raj, Shailendra Asthana, Shailendra Mani, Sweety Samal, Amit Awasthi, Shubbir Ahmed. Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach. Int J Biol Macromol. 2022 Jun 1;209(Pt A):1359-1367.  https://pubmed.ncbi.nlm.nih.gov/3546995 1/
  13. Rajat Ujjainiya, Akansha Tyagi, Viren Sardana, Salwa Naushin, Nitin Bhatheja, Kartik Kumar, Joydeb Barman, Satyartha Prakash, Rintu Kutum, Akash Kumar Bhaskar, Prateek Singh, Kumardeep Chaudhary, Menka Loomba, Yukti Khanna, Chestha Walecha, Rizwan Ahmed, Ashutosh Yadav, Archana Bajaj, Gaurav Malik, Sahar Qureshi, Swati Waghdhare, Samreen Siddiqui, Kamal Krishan Trehan, Manju Mani, Rajiv Dang, Poonam Das, Pankaj Dougall, Monica Mahajan, Sudipta Sonar, Kamini Jakhar, Reema Kumar, Mahima Tiwari, Shailendra Mani, Sankar Bhattacharyya, Sandeep Budhiraja, Anurag Agrawal, Debasis Dash, Sujeet Jha, Shantanu Sengupta. High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge. Nat Commun. 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975928/
  14. Vikram Saini, Priya Kalra, Manish Sharma, Chhavi Rai, Vikas Saini, Kamini Gautam, Sankar Bhattacharya, Shailendra Mani, Kanchan Saini, Sunil Kumar. A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis. Microbiol Spectr. 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653843/
  15. Ramachandran Thiruvengadam, Amit Awasthi, Guruprasad Medigeshi, Sankar Bhattacharya, Shailendra Mani, Sridhar Sivasubbu, Tripti Shrivastava, Sweety Samal, Deepika Rathna Murugesan, Bapu Koundinya Desiraju, Pallavi Kshetrapal, Rajesh Pandey, Vinod Scaria, Praveen Kumar Malik, Juhi Taneja, Akshay Binayke, Tarini Vohra, Aymaan Zaheer, Deepak Rathore, Naseem Ahmad Khan, Heena Shaman, Shubbir Ahmed, Rajesh Kumar, Suprit Deshpande, Chandru Subramani, Nitya Wadhwa, Nimesh Gupta, Anil K Pandey, Jayanta Bhattacharya, Anurag Agrawal, Sudhanshu Vrati, Shinjini Bhatnagar, Pramod Kumar Garg, Department of Biotechnology India Consortium for COVID-19 research. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses. Lancet Infect Dis. 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616567/
  16. Zaigham Abbas Rizvi, Manas Ranjan Tripathy, Nishant Sharma, Sandeep Goswami, N Srikanth, J L N Sastry, Shailendra Mani, Milan Surjit, Amit Awasthi, Madhu Dikshit. Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19. Front Pharmacol. 2021 Oct 14;12:746729.  https://pubmed.ncbi.nlm.nih.gov/34721035/   
  17. Reshma Perween, Murugavelu PraveenKumar, Tripti Shrivastava, Hilal Ahmed Parray, Vanshika Singh, Swarandeep Singh, Adarsh Chiranjivi, Kamini Jakhar, Sudipta Sonar, Mahima Tiwari, Reema, Anil Kumar Panchal, Chandresh Sharma, Deepak Kumar Rathore, Shubbir Ahamed, Sweety Samal, Shailendra Mani, Sankar Bhattacharyya, Supratik Das, Kalpana Luthra, Rajesh Kumar. The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41. Int Immunopharmacol. 2021 Sep 28;101(Pt B):108187. https://pubmed.ncbi.nlm.nih.gov/34649114/
  18. Abhisek Dwivedy, Richard Mariadasse, Mohammed Ahmad, Sayan Chakraborty, Deepsikha Kar, Satish Tiwari, Sankar Bhattacharyya, Sudipta Sonar, Shailendra Mani, Prafullakumar Tailor, Tanmay Majumdar, Jeyaraman Jeyakanthan, Bichitra Kumar Biswal. Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2. PLoS Comput Biol. 2021 Sep 13;17(9):e1009384. https://pubmed.ncbi.nlm.nih.gov/34516563/
  19. Praveenkumar Murugavelu, Reshma Perween, Tripti Shrivastava, Vanshika Singh, Hilal Ahmad Parray, Swarandeep Singh, Adarsh Kumar Chiranjivi, Ramachandran Thiruvengadam, Savita Singh, Naveen Yadav, Kamini Jakhar, Sudipta Sonar, Shailendra Mani, Sankar Bhattacharyya, Chandresh Sharma, Preeti Vishwakarma, Ritika Khatri, Anil Kumar Panchal, Supratik Das, Shubbir Ahmed, Sweety Samal, Pallavi Kshetrapal, Shinjini Bhatnagar, Kalpana Luthra, Rajesh Kumar. Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus. Int Immunopharmacol. 2021 Oct;99:108020. https://pubmed.ncbi.nlm.nih.gov/34426117/   
  20. Sameer Kumar Malladi, Unnatiben Rajeshbhai Patel, Raju S Rajmani, Randhir Singh, Suman Pandey, Sahil Kumar, Sara Khaleeq, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Savitha Gayathri, Debajyoti Chakraborty, Parismita Kalita, Ishika Pramanick, Nupur Agarwal, Poorvi Reddy, Nidhi Girish, Aditya Upadhyaya, Mohammad Suhail Khan, Kawkab Kanjo, Madhuraj Bhat, Shailendra Mani, Sankar Bhattacharyya, Samreen Siddiqui, Akansha Tyagi, Sujeet Jha, Rajesh Pandey, Shashank Tripathi, Somnath Dutta, Alexander J McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S Vasan, Rajesh P Ringe, Raghavan Varadarajan. Immunogenicity and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor Binding Domain Derivative. ACS Infect Dis. 2021 Jul 14.  https://pubmed.ncbi.nlm.nih.gov/34260218/
  21. Rohit Verma, Sandhini Saha, Shiv Kumar, Shailendra Mani, Tushar Kanti Maiti, Milan Surjit. RNA-Protein Interaction Analysis of SARS-CoV-2 5' and 3' Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection. mSystems. 2021 Jul 13;e0064321.  https://pubmed.ncbi.nlm.nih.gov/34254825/
  22. Tripti Shrivastava*, Balwant Singh , Zaigham Abbas Rizvi, Rohit Verma, Sandeep Goswami, Preeti Vishwakarma, Kamini Jakhar, Sudipta Sonar, Shailendra Mani, Sankar Bhattacharyya, Amit Awasthi, Milan Surjit. Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model. Front Immunol. 2021 May 24;12:641447. https://pubmed.ncbi.nlm.nih.gov/34108961/
  23. Shailendra Mani*, Tripti Shrivastava, Sankar Bhattacharyya, Nagender Rao Rameshwaram, Sweety Samal, Sandeep Goswami, Ashok Kumar, Ramandeep Singh, Niraj Kumar, Nitya Wadhwa, Uma Chandra Mouli Natchu, Ramachandran Thiruvengadam, Shailaja Sopory, Pallavi Kshetrapal, Bapu Koundinya Desiraju, Vandita Bhartia, and DBT India consortium for COVID-19 Research. A Luminex based serological assay for detecting IgM and IgG antibody response in SARS-CoV2 patients. Authorea. June 23, 2020. Preprint DOI: 10.22541/au.159294169.97530983 https://www.azendoo.authorea.com/users/336148/articles/461913 * Corresponding Author
  24. Ashok Kumar, Rita Singh, Jaskaran Kaur, Sweta Pandey, Vinita Sharma, Lovnish Thakur, Sangeeta Sati, Shailendra Mani, Shailendra Asthana, Tarun Kumar Sharma, Susmita Chaudhuri, Sankar Bhattacharyya and Niraj Kumar*. Wuhan to World: The COVID-19 Pandemic. Front Cell Infect Microbiol, 2021 Mar 30;11:596201. https://pubmed.ncbi.nlm.nih.gov/33859951/
  25. Preeti Vishwakarma, Naveen Yadav, Zaigham Abbas Rizvi, Naseem Ahmed Khan, Adarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan Dwivedi, Tripti Shrivastava, Rajesh Kumar, Amit Awasthi, Shubbir Ahmed, Sweety Samal*. Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro. Front Immunol. 2021. Mar 26;12:613045.  https://pubmed.ncbi.nlm.nih.gov/33841395/
  26. Sameer Kumar Malladi, Randhir Singh, Suman Pandey, Savitha Gayathri, Kawkab Kanjo, Shahbaz Ahmed, Mohammad Suhail Khan, Parismita Kalita, Nidhi Girish, Aditya Upadhyaya, Poorvi Reddy, Ishika  Pramanick, Munmun Bhasin, Shailendra Mani, Sankar Bhattacharyya, Jeswin Joseph, Karthika  Thankamani, V. Stalin Raj, Somnath Dutta, Ramandeep Singh, Gautham Nadig, Raghavan Varadarajan*. Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment. J Biol Chem. 2020  https://pubmed.ncbi.nlm.nih.gov/33154165/
  27. Hilal Ahmed Parray, Adarsh Kumar Chiranjivi, Shailendra Asthana, Naveen Yadav, Tripti Shrivastava, Shailendra Mani, Chandresh Sharma, Preeti Vishwakarma, Supratik Das, Kamal Pindari, Subrata Sinha, Sweety Samal, Shubbir Ahmed, Rajesh Kumar. Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library. J Biol Chem. 2020 Jul 29; jbc.AC120.014918. https://pubmed.ncbi.nlm.nih.gov/32727845/    
  28. Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou, Zhengli Shi. Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerging Microbes & Infections, 2019. https://www.ncbi.nlm.nih.gov/pubmed/31645223
  29. Aaron Irving, Pritisha Rozario, Pui San Kong, Katarina Luko, Jeffrey Gorman, Marcus Hastie, Wan Ni Chia, Shailendra Mani, Bejamin Lee, Gavin Smith, Ian Mendenhall, H. Larman, Stephen J. Elledge, and Lin-Fa Wang. Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Cellular and molecular life sciences, 2019. https://www.ncbi.nlm.nih.gov/pubmed/31352533
  30. Chee Wah Tan, Kevin Wittwer, Xiao Fang Lim, Anna Uehara, Shailendra Mani, Lin-Fa Wang, Danielle E. Anderson. Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans. Emerging microbes & infections, 2019. https://www.ncbi.nlm.nih.gov/pubmed/31132935
  31. Matae Ahn, Danielle E. Anderson, Qian Zhang, Chee Wah Tan, Beng Lee Lim, Katarina Luko, Ming Wen,Wan Ni Chia, Shailendra Mani, Loo Chien Wang, Justin Han Jia Ng, Radoslaw M. Sobota, Charles Antoine Dutertre, Florent Ginhoux, Zheng-Li Shi, Aaron T. Irving, Lin-Fa Wang. Dampened NLRP3 mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology, 2019. https://www.nature.com/articles/s41564-019-0371-3
  32. Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E. Anderson, LinFa Wang. Serological evidence of bat orthoreovirus infection, Singapore. Journal of Medical Virology, 2018.https://www.ncbi.nlm.nih.gov/pubmed/30411364
  33. Shailendra Mani, Chee Wah Tan, Danielle E. Anderson, Lin-Fa Wang. Serological investigation of four infection scenarios for Zika and Dengue viruses in monkeys. Virologica Sinica, 2018.https://www.ncbi.nlm.nih.gov/pubmed/30155852
  34. Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-jie Mai, Zi-Xian Wu, Di Li, Danielle E. Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan LI, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma. Nature, 2018. https://www.ncbi.nlm.nih.gov/pubmed/2961881
  35. Lav Tripathi*, Shailendra Mani*, Rajendra Raut*, Ankur Poddar, Poornima Tyagi, Upasana Arora, Aravinda de Silva, Sathyamangalam Swaminathan, Navin Khanna. Pichia pastoris-expressed dengue 3 envelope-based virus-like particles elicit predominantly domain III-focused high titer neutralizing antibodies. * Co-first Author Frontiers in Microbiology, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26441930
  36. Shailendra Mani, Lav Tripathi, Rajendra Raut, Poornima Tyagi, Upasana Arora, Tarani Barman, Ruchi Sood, Alka Galav, Wahala Wahala, Aravinda de Silva, Sathyamangalam Swaminathan, Navin Khanna. Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies. PLOS ONE, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23717637
  1. Assays for Detecting Henipavirus Antibodies. Lin-Fa Wang, Shailendra Mani, Chee Wah Tan, Danielle E Anderson. Methods Mol Biol. 2023;2682:245-258. doi: 10.1007/978-1-0716-3283-3_18. PMID: 37610587, https://pubmed.ncbi.nlm.nih.gov/37610587/
  1. Pichia pastoris expressed dengue envelope based virus like particles as safe, efficacious and in expensive dengue subunit vaccines. Indian patent No. 1663/DEL/2011. Shailendra Mani, Lav Tripathi, Karthik Dhatchinamoorthy, Poornima Tyagi, Rajendra Raut,Sathyamangalam Swaminathan, Navin Khanna. 

  2. Novel silver nano based aqueous sanitizer against pathogens. CBR No. 22957, application no. 202011030085, docket no. 71815.

1.     Funding Agency: Coalition for Epidemic Preparedness Innovations (CEPI)   

        Multiepitope Nanoparticle-based Broadly Protective Betacoronavirus Candidate Vaccine 

2.     Funding Agency: Bill & Melinda Gates Foundation (BMGF)                         

        Global Immunology and Immune Sequencing for Epidemic Response (GIISER) South Asia

Dr. M.K. Bhan Group Award for the most impactful collaborative research       2022-2023

Dr. M.K. Bhan Group Award for the most impactful collaborative research       2021-2022

Dr. M.K. Bhan Group Award for the most impactful collaborative research       2020-2021

MS.TANIA SARKAR
PROJECT ASSOCIATE-I

MR.BANWARI LAL
SENIOR RESEARCH ASSOCIATE

  • SHAILENDRAMANI[AT]THSTI[DOT]RES[DOT]IN