English हिंदी
  • भारत सरकार के विज्ञान एवम प्रौदयोगिकी मंत्रालय के जैव प्रौदयोगिकी विभाग की स्वायत्त संस्थान
  • AN AUTONOMOUS INSTITUTE OF DEPT. OF BIOTECHNOLOGY, MINISTRY OF SCIENCE AND TECHNOLOGY, GOVT OF INDIA
  • होम
  • संकाय प्रोफ़ाइल

DR.SUSMITA CHAUDHURI

Ph.D.

ASSISTANT PROFESSOR

  • Ph.D., National Institute of Cholera & Enteric Diseases, University of Calcutta.
  • M.Sc., University of Calcutta.
  • B.Sc., Presidency College, University of Calcutta.

Research Focus of the lab:

• Antimicrobial Resistance
• Life as a bacteria - active and dormant...and in a (bio)film
• Alternative diagnostic and therapeutic solutions for drug resistance microbial infections - MAbs, peptides, phages

Our present research interest is focused on anti-microbial resistance (AMR) by developing innovative diagnostics and drug delivery formulations for bacterial infections. We emphasize on a multi-pronged approach to tackle AMR with rapid, point of care diagnostics, improved formulations for controlling hospital acquired infections and developing alternetive to antibiotics. With this long-term goal, we delve into in depth mechanistic studies of viable-but-non-culturable (VBNC) state of bacteria and microbes in biofilms relevant to bacterial species critical for human health.

Research Experience

  • Scientist D, Centre for Biodesign and Diagnostics, THSTI, 2018-2019

  • Scientist C, Centre for Biodesign and Diagnostics, THSTI, 2011-2018

  • Senior Scientist in Biopharmaceutical R&D, Panacea Biotec Ltd., New Delhi (2007-2011)

  • Postdoctoral Fellow in Department of Medical Microbiology & Immunology, University of Alberta, Canada (2005-2007)

Publication
  • Colistin Potentiation in Multidrug Resistant Acinetobacter baumannii by a Non-cytotoxic Guanidine Derivative of Silver. Deepak Kumar,…..Susmita Chaudhuri. Frontiers in Microbiology, 2022, Volume 13 - 2022. https://doi.org/10.3389/fmicb.2022.1006604.
  • Antibiotic resistance of uropathogens among the community-dwelling pregnant and nonpregnant female: a step towards antibiotic stewardship. Sarita Mohapatra,….Susmita Chaudhuri….Harish Salve. BMC Infectious Diseases. 22, 939 (2022). https://doi.org/10.1186/s12879-022-07914-1.
  • Formic Acid, an Organic Acid Food Preservative, Induces Viable-But-Non-Culturable (VBNC) State and Triggers New AMR Traits in A. baumanii and K. pneumoniae. Manisha Yadav,….Susmita Chaudhuri. Frontiers in Microbiology, 2022, DOI=10.3389/fmicb.2022.966207
  • A Combination Therapy Strategy for Treating Antibiotic Resistant Biofilm Infection Using Guanidinium Derivative and Nanoparticulate Ag(0) Derived Hybrid Gel Conjugate. Ananta Dey…..Susmita Chaudhuri*, Amitava Das*. Chemical Science, 2022, DOI: 10.1039/D2SC02980D. (*Joint Corresponding).
  • Virulence gene mutations as a differentiator of clinical phenotypes: Insights from community-acquired uropathogenic Escherichia coli. Manisha Yadav,..Susmita Chaudhuri*, Sarita Mohapatra* (*Joint Corresponding). Microbiology. 2022.168:001161.
  • Heavy Metal and Imidazole Rich Pharmaceutical Effluent Increases AMR Traits and Induces Microbial Persistence Through VBNC Formation. manisha yadav,.....Susmita Chaudhuri. International journal of infectious diseases. 2022.116:S10; DOI: 10.1016/j.ijid.2021.12.024
  • Biofilm inhibiting nanocomposite coatings on stainless steel surgical instruments: a possible strategy to prevent TASS. Birru Bhaskar, Ramay Patra, ….Susmita Chaudhuri#, R. Subasri# & Prashant Garg#. 2022, Journal of Coatings Technology and Research, DOI:10.1007/s11998-022-00689-9  (# Co-corresponding)
  • Biofilm Inhibiting Nanocomposite Coatings on Surgical Sutures: Durability and Mechanistic Insights. R Subasri, … Susmita Chaudhuri#, Prashant Garg# (# Co-corresponding). J Coat Technol Res (2022). https://doi.org/10.1007/s11998-022-00678-y.
  • Biofilm Inhibiting Nanocomposite Coatings - A promising alternative to combat surgical site infections. Ramay Patra, …. Susmita Chaudhuri#, Prashant Garg#, R SubasriJ Coat Technol Res (2022).  https://doi.org/10.1007/s11998-022-00642-w  (# Co-corresponding).
  • Longitudinal serology in SARS-CoV-2 infected individuals in India – a prospective cohort study. Ramachandran Thiruvengadam,…..Susmita Chaudhuri….Shinjini Bhatnagar. The American Journal of Tropical Medicine and Hygiene. Am. J. Trop. Med. Hyg., 105(1), 2021, pp. 66–72
  • The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: an AMR Insights global Perspective. 2021. Shamsul Ansari,….Susmita Chaudhuri…..MBM van Dongen. JAC Antimicrob Resist. doi:10.1093/jacamr/dlab038
  • Wuhan to World: The COVID-19 Pandemic. A Kumar,….Susmita Chaudhuri….N Kumar. Front Cell Infect Microbiol. 2021; 11: 596201.
  • Comparative evaluation of SARS-CoV-2 IgG immunoassays in India.  Susmita Chaudhuri et.al., J Clin Virol, 2020, 24;131:104609.
  • Essential laboratory diagnostic at each level of health laboratory services in South East Asia region. Susmita Chaudhuri et. al., World Health Organization, 2020.
  • Das B, Chaudhuri S*, Srivastava R, Nair GB, Ramamurthy T. Fostering Research into Antimicrobial Research In India. British Medical Journal. 2017. 358: j3535. (Co-corresponding)
  • Kumar N,  Gupta DG, Kumar S, Maurya P, Tiwari  A,  Mathew B, Banerjee S, Hadlar S, Pillai J,  Bhatnagar  S and  Chaudhuri S. Exploring packaged microvesicle proteome composition of Chinese Hamster Ovary secretome. J Bioprocess Biotech. 2016. 6:274.
  • Chaudhuri  S,  Maurya P,  Kaur  M,  Tiwari  A,  Borth  N,  Bhatnagar  S and  Kumar  N. Investigation  of  CHO  Secretome:  Potential  Way  to  Improve  Recombinant Protein Production from Bioprocess . 2015.  J Bioprocess Biotech 2015, 5:7 
  • Sharma C, Sankhyan A, Sharma T, Khan N, Chaudhuri S, Kumar N, Bhatnagar S, Khanna N, Tiwari A. A repertoire of high-affinity monoclonal antibodies specific to S. typhi: as potential candidate for improved typhoid diagnostic. Immunol Res. 2015.
  • S Chaudhuri, ... L J. Guilbert. Human cytomegalovirus interacts with TLR2 and CD14 on syncytiotrophoblasts to stimulate TNFα mRNA & apoptosis. Placenta. 2009. 30:994-1001.
  • Chaudhuri S, ... Naik TN. Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India. J Clin Virol. 2005 Jan;32(1):38-46.
  • S. Das, V. Varghese, S. Chaudhuri, ...T. N. Naik.. Genetic variability of human rotavirus strains isolated from Eastern and Northern India. J Med Virol. 2004 Jan; 72 (1): 156-61.
  • P. Barman, S. Ghosh, S. Das, V. Varghese, S. Chaudhuri, ...T.N. Naik. Sequencing and sequence analysis of VP7 and NSP5 genes reveal emergence of new genotype of bovine Group B rotaviruses in India. J Clin Microbiol. 2004 Jun; 42 (6): 2816-2818.
  • Das S, Varghese V, Chaudhuri S, ... Naik TN. Emergence of Novel Human Group A Rotavirus G12 Strains in India. J Clin Microbiol 2003; 41: 2760-2762.
  • Chowdhury A, Santra A, Chaudhuri S, ... Mazumdar DNG. Hepatitis C virus Infection in General Population: A Community Based Study in West Bengal, India. Hepatology 2003; 37: 802-809.
  • Das S, Sen A, Uma G, Varghese V, Chaudhuri S, ....Naik TN. Genomic Diversity of Group A Rotavirus Strains Infecting Humans in Eastern India. J Clin Microbiol 2002; 40: 146-149.


 

  • Method of improving stability of recombinant protein product in CHO batch culture by selective removal of metalloproteinase rich exosomal fraction and uses thereof (2015)
  • Method of flow cytometry based rapid antimicrobial susceptibility testing and uses thereof (2017)
  • Discontinuous lateral flow test strip and method (2018)
  • Novel oxone-based sanitizer protect against toxic pathogens (2020)
  • Novel Fenton reagent-based sanitizer protect against toxic pathogens  (2020)
  • Biofilm inhibiting sol-gel composition for coating on substrates and process of preparing the same (2021)
  • Antimicrobial biofilm containing silver nanoparticles (2021)

1. Emerging drug resistance of uropathogens in community acquired urinary tract infection and molecular insights into dynamics of resistance traits in Indian isolates- A pan-India multi-centric study; ICMR; 2019-2022

2. A study of Ashwagandha administration in participants vaccinated against COVID-19 on safety, immunogenicity, and protection: A randomized, double blind, placebo controlled, multi-centric clinical trial; AYUSH CCRAS; 2021-23

·        Tie-BIRAC award for Women in Entrepreneurial Research, 2018.

·        NIH-Fogarty fellowship on Indo-US Framework Program on Global Health Innovation, sponsored by NIH-Fogarty International Centre for Microfluidics and Imaging training at Tufts University, Boston, USA, 2017.

·        Biotechnology Ignition Grant award for the development of ‘Rapid Point-of-care field deployable typhoid diagnostics’ by BIRAC, 2017.

·        MFN Strategic Training Programme fellowship, Perinatal Research Centre, University of Alberta, Canada, 2006-2007.

·        'Best Poster Award'; Poster entitled 'Molecular Epidemiology of HCV Infection among Acute and Chronic Liver Disease Patients in Kolkata'; VI-Sir Dorabji Tata Symposium on Viral Hepatitis at the Indian Institute of Science, Bangalore, India, on March 10-11, 2005.

·        National Scholarship (1997-98) of the Gov. of India on the result of B.Sc. (Zoology Hons.) Examination of Calcutta University.

·        'Sarasibala Chaudhuri' scholarship in the year 1997 for ranking 1st Class 2nd in Calcutta University in B.Sc. (Zoology Hons.) Exam.

Entrepreneurial Venture:

Co-Founder of Tritek Innovation Pvt. Ltd., based in THSTI Interim Incubation Centre, NCR Biotech Science Cluster, Faridabad.

DR. CHAITALI SINGHAL, MKB-YRFP FELLOW, THSTI

MS. SONALI POREY KARMAKAR, TECHNICAL OFFICER-II, THSTI

MS. MANISHA YADAV, PH.D STUDENT, THSTI

MR. SUBHASH CHANDRA TANWAR, TECHNICAL OFFICER-I, MCTR

MS. SWETA PANDEY, PH.D STUDENT, THSTI

MR. DEEPAK KUMAR, PH.D STUDENT, THSTI

MS. POOJA JOSHI, PH.D STUDENT, THSTI

MS. AKANKSHA CHAUHAN, PROJECT ASSOCIATE-I, MCTR

MS. SAKSHI, PROJECT ASSOCIATE-I, MCTR

Ms. Samridhi Dhyani, Project Associate I

Mr. Rajkumar Dwivedi, Lab Technician

Mr. Niranjan Kumar, Lab Technician

  • SUSMITA[AT]THSTI[DOT]RES[DOT]IN