DR.SUCHITRA DEVI GOPINATH
Ph.D
RESEARCH SCIENTIST
- Post doctorate, Stanford University, California, USA
- Ph.D, Center for Cellular and Molecular Biology, Hyderabad, India
- M.Sc. Zoology, University of Pune, Pune, India
My area of interest includes lean muscle metabolism and function particularly in the context of maternal and child health. To recapitulate uterine influences and identify metabolic features programmed within the fetus, we use umbilical cord mesenchymal stem cells (uMSCs) as a reporter system to study fetal organogenesis. One of the key tissues involved in systemic metabolic physiology is lean muscle that regulates glucose homeostasis and secretes myokines facilitating inter organ cross talk. Infants with less lean muscle are more predisposed to multiple NCDs. We want to determine how maternal factors such as micronutrients and lean muscle influence offspring body composition using the uMSCs system. In parallel, we have built a compendium of muscle metabolites and a system to induce contractility in muscle cells using Electric Pulse stimulation (EPS) to screen myokines enabling muscle function. These in vitro systems aim to provide a comprehensive detailed picture on how fetal body composition and lean muscle function is programmed by the uterine milieu.
Publication
Sevak JK & Gopinath S.D*. Generation of mesenchymal stem cells from human umbilical cord tissue and their differentiation into the skeletal muscle lineage.
Das A, Gopinath S.D* & G Aneeshkumar Arimbasseri* (2021). Systemic ablation of vitamin D receptor leads to skeletal muscle glycogen storage deficit disorder in mice. Journal of Cachexia, Sarcopenia and Muscle. DOI: 10.1002/jcsm.12841.
Mishra S, Sevak JK, Das Anamica, Arimbasseri G Aneeshkumar, Bhatnagar Shinjini and Gopinath S.D. (2020). Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood. Scientific Reports. 10 (18978). doi.org/10.1038/s41598-020-
Kumar A, Kumar Y, Kumar J, Kumar S, Kumar N, and Gopinath S.D (2020). Metabolomic analysis of primary human skeletal muscle cellsduring myogenic progression. Scientific Reports. 10(1184). doi .10.1038/s41598-020-68796-4
Gopinath S.D (2017) Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor. Skeletal Muscle . 7:2. doi. 10.1186/s13395-017-0121-2
Biressi S* and Gopinath S.D* (2015) The quasi-parallel lives of satellite cells and atrophying muscle. Front.Aging Neurosci. doi: 10.3389/fnagi.2015.00140 (*co- corresponding author).
Biressi S., Miyabara E., Gopinath S.D., Carlig P., Rando T.A (2014) Wnt-TGFb2 axis regulates the fate of muscle stem cells in dystrophic muscles. Sci Transl Med. Dec 17;6(267):267ra176. doi:10.1126/scitranslmed.3008411.
Gopinath S.D., Webb E.A., Brunet A., Rando T.A. (2014) FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports, April 8 (2): 414-426.
Gopinath S.D., Rando T.A. (2008). Stem Cell review Series: Aging of the skeletal muscle stem cell niche. Aging Cell
Aug;7(4):590-8.
Gopinath S.D., Narumiya S, Dhawan J (2007). The RhoA effector mDiaphanous regulates MyoD expression via SRF- dependent and SRF-independent pathways. J. Cell Sci. Sep 1;120(Pt 17):3086-98.
Adult stem cells in regenerative Medicine”, Gopinath S.D. (in progress). Ane Books, Pvt.Ltd. Ansari Road, New Delhi.
1. Effect of maternal micronutrients on offspring lean muscle proportions
2. Generation of in vitro models mimicking intra uterine muscle development and physiology
3. Developing models to address ntergenerational body compostion phenotypes to address how maternal body composition might influence offspring metabolic profiles and lean muscle proportions
1) Junior Research Fellowship awarded by the Counsil of Scientific and Industrial Research (CSIR), India
2) Senior Research Fellowship awarded by the Council of Scientific and Industrial Research (CSIR), India
3) American Society for Cell Biology (ASCB) Predoctoral Travel Award, 2004
4) Innovative Young Biotechnologist (IYBA) Award-2015
5) CSIR Travel grant Award for attending Gordon Research Conference on Myogenesis in Tuscany, Il Ciocco, June 2017
Scientific communication:
Science2October2015:30-31.“Fundingdreams”. http://www.sciencemag.org/content/350/6256/30.full
Science 3 July 2015: 24-27. “Postdocs reimagined”.http://www.sciencemag.org/content/349/6243/24/ suppl/DC1
Science 01 April 2016: 28-30. “Measures of Success”.http://science.sciencemag.org/content/352/6281/28/suppl/DC
Science 01 January 2021: 22-24. “Defining events: 2020 in hindsight”.https://science.sciencemag.org/content/371/6524
Committee membership:
Stem Cell Ethics Committee of Regional Centre of Biotechnology (RCB), 2019-2020
Reviewer role
Scientific Reports, Gut Microbiome, Journal of Cellular Physiology, Journal of Steroid Biochemistry and Molecular Biology, Frontiers in Physiology, Journal of Stem Cell research and Therapy, Biological Procedures Online, Journal of Biosciences
Poster presentation and talks (International)
- InvitedspeakerattheEuropeanMolecularBiologyOrganization(EMBO)workshop,on“Cellinteractionsin development and Disease” on Dec 16th-18th 2004, at Centre for Cellular and Molecular Biology, Hyderabad,India, “Regulation of MyoD inmyoblasts”.
- Poster Presentation at the FASEB Conference: Skeletal Muscle Satellite and Stem Cells, Carefree, USA, Jul2010.“Regulation of satellite cell function by the FoxO family of transcriptionfactors”.
- InvitedspeakerattheGordonResearchConference:Notchsignalingindevelopment,regenerationanddisease, Maine,USA,August 12-18th2012.“RegulationofNotchsignalingbyFoxO3inmusclestemcellsduringmuscle regeneration”.
- Poster presentation at the Gordon Research Conference: Myogenesis, Renaissance, Il Ciocco, Lucca, Barga, Tuscany, Italy. June 11th -16th, 2017. “Role of vitamin D signaling in the regulation of skeletal muscle mass”.
MR.OJAS TIKOO
PROJECT ASSOCIATE-I
- 01292876372
- SGOPINATH[AT]THSTI[DOT]RES[DOT]IN