- MSc. Genetics, South Campus, Delhi University
- Ph.D., Center for Cellular and Molecular Biology, Hyderabad
- Post-doctoral fellow Harvard Medical School, Boston. USA
Dr Pallavi Kshetrapal is a molecular geneticist who obtained her PhD degree from Centre for Cellular and Molecular Biology (CCMB), Hyderabad and post-doctoral research training from Harvard Medical School Boston, USA. The focus of her lab is to study molecular pathways that are clinically relevant in adverse pregnancy. Using a range of different “omics’ approaches, studies that are described below, the lab is focused towards identification of biomarkers from human circulating blood and from human placenta that can be utilised for development of translational modalities against adverse pregnancies.
Biomarker discovery for prediction of pregnancy complications and adverse pregnancy outcomes
Dr. Pallavi Kshetrapal’s lab is currently involved in identification and validation of biomarkers circulating in maternal bodily fluids associated to adverse pregnancy outcomes. The methodology involved utilises agnostic multi-pronged “omics” approach. Identified molecular signatures would then be validated and developed as potential biomarker/s for determination of risk assessment in a pregnant mothers. A classification algorithm based on various clinical and molecular determinant/s from mutltivariate data generated in a longitudinal cohort study may lead to generation of better models of risk stratification for assisting clinical interventions.
Understand the cellular and biochemical pathways functioning in the human placenta for maintaining a healthy pregnancy
Placenta is a feto-maternal organ and is known to govern the outcome of pregnancy. In another ongoing study her lab intends to emphasize the use of circulating placenta-specific extracellular vesicles for diagnosing the adverse pregnancy outcome. These vesicles are being studied to identify the enveloped cargo capable of transducing signals from and to the fetus for healthy growth and development. Dr. Pallavi Kshetrapal’s lab is interested in identification and validation of placenta-specific markers in maternal circulation in normal and complicated pregnancies. They plan to use in vitroapproaches to highlight the putative utility of such tissue-specific extracellular vesicles (e.g. exosomes) in the prediction of adverse pregnancy outcomes and for treatment monitoring by studying the change in the placental function as the pregnancy progresses.
1. Hoh JK, Lappas M, Liu C, Qiao C, Pallavi K, Takeda J, Kim YJ. (2019) Preterm birth rate and dilemma of preterm labor treatment in Asia. Professor Jeongkyu Hoh (2019) Placenta,Feb 15. pii: S0143-4004(18)31070-1.
2. Shweta Birla,1 PhD., Vijayakumar P,2 M.Sc., Shilpi Sehgal,2 M.Sc., Shinjini Bhatnagar2, M.D., Pallavi S. K.,2*PhD., Arundhati Sharma,1*PhD. (2019) Characterization of a novel POU1F1 mutation identified on screening 160 growth hormone deficiency patients. Hormone and Metabolic Research, Horm Metab Res. 2019 Apr;51(4):248-255.
3. Ramkumar Menon, PhD,1*$Chirantan Debnath,2$Andrew Lai, PhD3, Dominic Guanzon, PhD3, Shinjini Bhatnagar, MD,2 Pallavi S. Kshetrapal., PhD,2*Samantha Sheller-Miller, PhD1,The Garbhini Study team#, Carlos Salomon, D.Med.Sc, PhD3,4* (2019) Circulating exosomal miRNA profile during term and preterm birth pregnancies – a longitudinal study. Endocrinology, Feb 1;160 (2):249-275.
1. Banerjee, Roy, Nath Bhaumik, Kshetrapal P, Pillai. (2018) Comparative study of oral lipid nanoparticle formulations (LNFs) for chemical stabilization of antitubercular drugs: physicochemical and cellular evaluation. Artif Cells Nanomed Biotechnol. Jan 26:1-19. doi:10.1080/21691401.2018.1431648.
1. Sehgal. S., Bhatnagar. S, and Pallavi S.K.*(2017). Provocative ideas on human placental biology: a prerequisite for prevention and treatment of neonatal health challenges". Am J Reprod Immunol. May;77 (5). doi: 10.1111/aji.12656.
1. Diana M. Ho Pallavi S. K, Spyros Artavanis Tsakonas. (2015). The Notch-mediated hyperplasia circuitry in Drosophilareveals a Src-JNK signaling axis. Elife.Jul 29;4:e05996. doi: 10.7554/eLife.05996.
1. Pallavi S. K, Diana M. Ho, Chindo Hicks, Lucio Miele, Spyros Artavanis Tsakonas. (2012)Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.EMBO J.May 11. doi. 10.1038/emboj.2012.129.
1. Silvia Fre, Pallavi S.K, Mathilde Huyghe, Marick Lae, Sylvie Robine, Spyros Artavanis-Tsakonas and Daniel Louvard. (2009).Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the mouse intestine. Proc Natl Acad Sci U S A. 6309–6314.
1. Pallavi S K*, Kannan R, Shashidhara LS. (2006).Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev Biol.296 (2):340-352.
1. Pallavi, S.K. and Shashidhara, L.S. (2005).Signaling capabilities of peripodial cells of the Drosophila wing imaginal disc. J Cell Sci.118: 3363-3370.
2. Berger C., Pallavi S. K., Prasad M., Shashidhara L. S. and Technau G. M. (2005).A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nature Cell Biology7, 56-62.
3. Berger C., Pallavi S. K., Prasad M., Shashidhara, L. S. and Technau, G. M. (2005).Cyclin E Acts under the Control of Hox-Genes as a Cell Fate Determinant in the Developing Central Nervous System. Cell Cycle. Mar 4; 4(3).
1. Bharathi V., Pallavi S. K., Bajpai R., Emerald B. S., and Shashidhara L.S. (2004).Genetic characterization of the Drosophila homologue of coronin. J Cell Sci.117, 1911-1922.
1. Pallavi S. K. and Shashidhara L. S. (2003).EGFR/Ras mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development130, 4931-1441.
· Awarded the Innovative Young Biotechnologist Awardby the Department of Biotechnology for the year 2014.
- Selected for the prestigious Ramanujan Fellowshipof Department of Science and Technology (DST) for the year 2012-2013.
- Selected for the prestigious Ramalingaswamy Re-entry Fellowshipof Department of Biotechnology (DBT) for the year 2012-2013.
- Selected as a Section Leaderfor the CB201 (CB201 http://cb201.med.harvard.edu/) at the Harvard Medical School, Boston, MA. 2009. Course Director Malcolm Whitman, Course Instructor: Sandra Ryeom.
- Awarded the Prof. LSS Kumar awardby the Indian National Science Academy for the year 2005.
- Awarded the INSA young Scientist Medalby the Indian National Science Academy for the year 2005.
- Awarded the Development Traveling Fellowshipto visit Dr Matthew Freeman’s lab at the Medical Research Council (MRC), Cambridge (March- April 2004).
- Visited Dr. Stephane Noselli’s Lab at Faculty de Sciences, Nice, France on an INDO-FRENCH exchange program(Jan-Feb 2004).
- Awarded Junior/Senior Research fellowship (2000) (National Eligibility Test) in the Life-Science category, conducted jointly by University Grants Commission and Council for Scientific and industrial Research (CSIR), INDIA.
- Awarded Delhi University, South Campus Endowment Scholarship. (1997-98).
- Awarded ShantiPrasad Puraskar from Delhi University for outstanding performance in B.Sc Botany (Hons.) (1994-97).
- Awarded a Science Meritorious Scholarshipfor securing first position in the college. (1994-97).
PhD registered currently: 1
2013 - present: Ms. Shilpi Sehgal
2019 - 2020: Dr. R. Thirunavukkarasu
Postdoctoral Research Fellows: 1
2017-2019: Dr. Mukesh Kumar Singh
2020 - Present: Ms. Arpita Singh, PhD Student
2019 - Present: M
Trainees and Research Fellows: 2
2020 : Ms. Varsha Dwivedi, JRF (Project)
2013-2019: Mr. Chirantan Debhnath, SRF (Project)
2014-2015: Mr. Vijay P Kumar, SRF (Project)
2016-2016: Mr. Viabhav Sabarwal, JRF (Project)
2016-2016: Ms. Anica Dhadwal, SRF (Project)
Junior Research Scientist C (Project): 1
2017- present: Dr. Savita Singh
Technician (Project): 2
2015- present: Mr. Amitab Bacchan
2017- present: Ms. Archana Rao