Publication

Some important publications: 

1.        Thiruvengadam R., Ayushi, Murugesan D.R., Desiraju B.K., Misra S., Sharma D., Subbaian S.S., Mehta U., Singh A., Sharma S., Khurana A., Mittal P., Chellani H., Bharti R., Tripathi R., Sopory S., Kshetrapal P., Salunke D.M., Natchu U.C.M., Ramji S., Wadhwa N., Bhatnagar S., and GARBH-Ini study team. Burden and Determinants of Small Vulnerable Newborns: Findings from a Prospective Pregnancy Cohort in South Asia-implications for public health. The Lancet Global Health, 2024 Aug;12(8):e1261-e1277. doi: 10.1016/S2214-109X(24)00212-2. In this article we reported a set of modifiable risk factors which predispose to the birth of small vulnerable newborns, those who are born too soon or too small. These risk factors can be addressed at the programmatic level to reduce the burden of mortality and morbidity associated with these babies.

2.        Gadekar V, Damaraju N, Xavier A, Thakur SB, Vijayram R, Desiraju BK et al., Development and external validation of Indian population-specific Garbhini-GA2 model for estimating gestational age in second and third trimesters. The Lancet Regional Health - Southeast Asia, 2024. https://doi.org/10.1016/j.lansea.2024.100362. This is the first Indian population specific pregnancy dating model performing better than the Western models. Now being taken forward to productization.

3.        Thiruvengadam R, Desiraju BK, Natchu UCM, Wadhwa N, Sachdeva K, Misra S, Parmar N, Juyal M, Mittal P, Bharti R, et al. Gestational weight gain trajectories in GARBH-Ini pregnancy cohort in North India and a comparative analysis with global references. European Journal of Clinical Nutrition 2022 Jun;76(6):855-62. doi: 10.1038/s41430-021-01040-y. This article demonstrated the need for a gestational weight gain standards that are applicable to Indian population. Now, as a follow up, our data is being incorporated into the WHO led effort for a globally relevant standard.

4.        Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A, Roggero P, Prefumo F, do Vale MS, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatrics 2021 Aug 1;175(8):817-26. doi: 10.1001/jamapediatrics.2021.1050. This was one of the first articles that demonstrated the adverse effects of COVID-19 on pregnancy outcomes. This informed the COVID-19 vaccine policy for pregnant women.

5.        Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, et al., Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses; 2022; The Lancet Infectious Diseases; 22; 4; 473; 482; 10.1016/S1473-3099(21)00680-0; 1474-4457. This report informed the COVID-19 vaccination strategy developed by NTAGI in India during the outbreak of the Delta variant.

For the full list, visit: https://scholar.google.co.in/citations?user=u1-fNLwAAAAJ&hl=en

Essential Diagnostics List 2019-20 for the World Health Organization—Southeast Asian Region (Co-author). This document lists the diagnostic tests essential for optimal care delivery in low-middle income countries.

·       Garbh-Ini Ultrasound Image-Based Gestational Age Estimation System (GAUGE); Indian Patent Application No. 202411027837; Filed on April 4, 2024. Role: Co-conceived the invention, designed and conducted the clinical study, and clinically evaluated the model.

·       A population-specific gestational dating system and a method thereof; Indian Patent Application No. 202341061748; Filed on September 13, 2023. Role: Conceived the invention, designed the clinical study, identified and clinically phenotyped the participants from whom the model was developed, and clinically evaluated the model.

·       Potently neutralizing novel human monoclonal antibodies to SARS-CoV-2 (COVID-19); Indian Patent Application No. 202111038519; Filed on August 25, 2021. Role: Designed the clinical study for the invention and identified and clinically phenotyped the participants from whom the monoclonal antibodies were generated and purified.

·       Immunoassay for detection of Coronaviridae; Indian Patent Application No. 202011039696; Filed on September 14, 2020. Role: Designed the clinical study for the invention, identified and clinically phenotyped the participants from whom the biospecimen was collected and the assay was developed; clinically evaluated the diagnostic assay.

1. GARBHINI - Interdisciplinary Group for Advanced Research on Birth Outcomes - DBT India Initiative
2. Generating critical and actionable insights to mitigate the adverse effects of environment and climate change on pregnancy outcomes
3. A nationwide development and validation of the Indian-population-specific pregnancy dating tools
4. Development and validation of an ultrasound-based triaging tool for high-risk pregnancy