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DR. SWEETY SAMAL, Ph.D  

Senior Research Scientist
+91-129-2876308 
sweety.samal [at] thsti [dot] res [dot] in
Ph.D in Virology from University of Maryland, College Park, 2012
M.V.Sc. in Virology & Bacteriology from Orissa University of Agriculture and Technology, 2007
B.V.Sc


Research Interests/ Research Summary

Our lab current research focuses on  virus characterization, next generation vaccine design for enveloped viruses and development of suitable animal model and novel assays for infectitious diseases, that will benefit  the evaluation of vaccine candidates, anti-viral drug screening and therapautics. Our lab long standing research interest is to carry out innovative scientific research on enveloped viral agents leveraging on the expertise gained from HIV ,Influenza and Paramyxoviruses, thus creating a ' Translational and Systems virology platform'. I have extensive working experiences in enhanced BSL3+ and ABSL3+ lab to work with CDC select agents. Our team have initiated work on SARS-CoV2 viruses and developed SARS-CoV2 pseudovirus neutralization assay. We  are growing, cultivating and characterizating the SARS-CoV2 viruses inside BSL3 facility.Furthermore, we are also conducting immunogenicity and antigenicty assessment of COVID-19 immunogen candidates in mouse model.

Fellowship and Membership of Professional Bodies

  • University of Maryland Block Fellowshipfrom 2010 to 2012.
  • University of Maryland Dean’s Fellowshipfrom 2008 to 2010.

Professional Affiliations

  • Member of the American society of virology (ASV)
  • Life member of the Indian Virological Society
  • Associate member of American association of avian pathologists (AAAP/AVMA)
  • Member of European AIDS Clinical Society (EACS) 

Membership of Editorial Boards

  • Reviewer for Indian Journal of Virology
  • Reviewer for Plos One
  1. Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro;Preeti Vishwakarma, Naveen YadavZaigham Abbas RizviNaseem Ahmed KhanAdarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan DwivediTripti ShrivastavaRajesh KumarAmit AwasthiShubbir Ahmed* and Sweety Samal* ,Front. Immunol., 26 March 2021 | https://doi.org/10.3389/fimmu.2021.613045

  2. Preclinical Animal Models for COVID-19 Research-Making a Wise Choice;Preeti Vishwakarma, Ritika Khatri, Gazala Siddiqui, Naveen Yadav, Zaigham Abbas Rizvi, Amit Awasthi, Sweety Samal;https://www.arcjournals.org/journal-of-immunology-and-vaccines/volume-5-issue-1/ARC Journal of Immunology and Vaccines. 2020; 5(1): 24-37
  3. Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development?Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development?Supratik DasRajesh Kumar*Shubbir Ahmed*, Hilal Ahmad Parray*Sweety Samal*; Therapeutic Advances in Vaccines and Immunotherapy,First Published October 8, 2020 Review Article
  4. Design and characterization of a germ-line targeting soluble, native-like, trimeric HIV-1 Env lacking key glycans from the V1V2-loop; Shubbir Ahmed, Tripti Shrivastava,  Rajesh Kumar, Mohit Kumar, Manidipa Banerjee, Naresh Kumar, Manish Bansal, Supratik Das; Sweety Samal;Biochimica et Biophysica Acta (BBA) - General Subjects,Volume 1865, Issue 1, January 2021, 129733
  5. Tetramerizing tGCN4 Domain Facilitates Production of Influenza A H1N1 M2e Higher Order Soluble Oligomers that Show Enhanced Immunogenicity In vivo. Sweety Samal*, Tripti Shrivastava, Praveen Sonkusre, Zaigham Abbas Rizvi, Rajesh Kumar, Shubbir Ahmed, Preeti Vishwakarma, Naveen Yadav, Manish Bansal, Kanchana Chauhan, Sebanta Pokhrel, Supratik Das, Padmakar Tambare and Amit Awasthi. Published on August 13, 2020 doi: 10.1074/jbc.RA120.013233. jbc.RA120.013233. Journal of Biological Chemistry (* Corresponding author)
  6.  Efficiently cleaved HIV-1 envelopes: Can they be important for vaccine immunogen development? Supratik Das, Rajesh Kumar, Shubbir Ahmed, Hilal Parray,Sweety Samal,DOI 10.1177/2515135520957763,Journal Therapeutic Advances in Vaccines and Immunotherapy, August 2020
  7. Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library " by Hilal Ahmed Parray, Adarsh Kumar Chiranjivi, Shailendra Asthana, Naveen Yadav, Tripti Shrivastava, Shailendra Mani, Chandresh Sharma, Priti Vishwakarma, Supratik Das, Kamal Pindari, Subrata Sinha, Sweety Samal, Shubbir Ahmed, and Rajesh Kumar. J Biol Chem, 2020 Jul 29; jbc.AC120.014918. doi: 10.1074/jbc.AC120.014918. Online ahead of print. PMID: 32727845, Journal of Biological Chemistry
  8. Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells. Khan NA, Singla M, Samal S, Lodha R, Medigeshi GR mSphere. 2020;5(3):e00447-20. Published 2020 May 27. doi:10.1128/mSphere.00447-20
  9. Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives. Parray HA, Shukla S, Samal S, Shrivastava T, Ahmed S, Sharma C, Kumar R.Int Immunopharmacol. 2020 May 27;85:106639. doi: 10.1016/j.intimp.2020.106639. Online ahead of print. PMID: 32473573 Free PMC article. Review.
  10. Antibody-based therapeutic interventions: possible strategy to counter chikungunya viral infection.Kumar R, Shrivastava T, Samal S, Ahmed S, Parray HA. Appl Microbiol Biotechnol. 2020 Apr;104(8):3209-3228. doi: 10.1007/s00253-020-10437-x. Epub 2020 Feb 19. PMID: 32076776 Free PMC article. Review.
  11. Efficiently cleaved HIV-1 envelopes: Can they be important for vaccine immunogen development? Supratik Das, Rajesh Kumar*, Shubbir Ahmed*, Hilal Ahmad Parray * and Sweety Samal*. Therapeutic Advances in Vaccines and Immunotherapy, Accepted August 2020. 
  12. Method to identify efficiently cleaved, membrane-bound, functional HIV-1 (Human Immunodeficiency Virus-1) envelopes. Samal S, Bansal M, Das S.MethodsX. 2019 Apr 17;6:837-849. doi: 10.1016/j.mex.2019.04.013. eCollection 2019.PMID:31049300 (First author)
  13. Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail. Samal S, Das S, Boliar S, Qureshi H, Shrivastava T, Kumar N, Goswami S, Bansal M, Chakrabarti BK. Retrovirology. 2018 Jul 20; 15(1):50. doi: 10.1186/s12977-018-0431-4.PMID:30029604 (First author)
  14. Envelope proteins of two HIV-1 clades induced different epitope-specific antibody response Tripti Shrivastava a,1 , Shrivastava T, Samal S*, Tyagi AK, Goswami S, Kumar N, Ozorowski G, Ward AB, Chakrabarti BK.Vaccine. 2018 Mar 14;36(12):1627-1636. doi: 10.1016/j.vaccine.2018.01.081. Epub 2018 Feb 9.PMID:29429810 Equal first co-author. 2017-2015,THSTI:
  15. Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with properties comparable to membrane-bound BG505. Das S, Boliar S, Samal S, Ahmed S, Shrivastava T, Shukla BN, Goswami S, Bansal M, Chakrabarti BK.Virology. 2017 Oct;510:22-28. doi: 10.1016/j.virol.2017.07.001. Epub 2017 Jul 6.PMID: 28689085
  16. Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes. Das S, Boliar S, Mitra N, Samal S, Bansal M, Koff WC, Chakrabarti BK.,Retrovirology. 2016 
  17. Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop.Patil S, Kumar R, Deshpande S, Samal S, Shrivastava T, Boliar S, Bansal M, Chaudhary NK, Srikrishnan AK, Murugavel KG, Solomon S, Simek M, Koff WC, Goyal R, Chakrabarti BK, Bhattacharya J.J Virol. 2016 Jan 13
  18. An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.Boliar S, Das S, Bansal M, Shukla BN, Patil S, Shrivastava T, Samal S, Goswami S, King CR, Bhattacharya J, Chakrabarti BK.PLoS One. 2015 Mar 30
  19. Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus.Khattar SK, Palaniyandi S, Samal S, LaBranche CC, Montefiori DC, Zhu X, Samal SK.Hum Vaccin Immunother. 2015
  20. Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity.Samal S, Khattar SK, Paldurai A, Palaniyandi S, Zhu X, Collins PL, Samal SK.J Virol. 2013 Sep. (First author)
  21. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity.Samal S, Khattar SK, Kumar S, Collins PL, Samal SK. J Virol. 2012 Mar;86(5):2501-11. doi: 10.1128/JVI.06380-11. Epub 2011 Dec 28. PMID: 22205748  (First author)
 
 
  • Completed patent filed in India IPA 201911027069; LIPC Ref: IP0337: ‘Recombinant H1N1 Influenza virus M2e ectodomain proteins, method of producing the same and uses thereof’ Sweety Samal, Tripti Shrivastava, Rajesh Kumar, Manish Bansal, Naresh Kumar, July 4, 2020

 

  • Provisional patent filed: SARS-COV2 SPIKE DOMAIN IMMUNOGENIC PEPTIDE-BASED VACCINE CANDIDATES AND USES THERE OF, TEMP/E1/31979/2020-DEL Sweety Samal, Shubbir Ahmed, Rajesh Kumar, Priti Vishwakarma, Naveen Yadav, Adarsh Chiranjivi July 2020
  • Improved Newcastle disease virus as vaccine and oncolytic agent (U.S provisional patent application number 61/860025).The invention has been  marketed to company AVIMEX,Mexico Avimex
  • US patent submitted Title: Native Trimeric Env Immunogen Design Patent Application.Bimal Chakrabarti, Saikat Boliar, Supratik Das, Tripti Shrivastava, Richte Charles King, Jayanta Bhattacharya,Sweety Samal(WO/2016/065252)
  • US Patent submitted LS-2013-068- Office Action - US 14/900,834 - Infectious laryngotracheitis virus (ILTV) vaccine using recombinant Newcastle disease virus vector,  Patent Number: 61857558

1.BIRAC-NBM grant on Translational Research Consortium for Establishing Platform Technologies to Support Prophylactic and Therapeutic Strategies for Dengue – Discovery to Proof-of-Concept"  .

2.Received Africa-India Mobility Fund (AIMF) grant, funded by Wellcome Trust 2020-2021

3.SERB grant Design, validation, and development of novel peptidomimetic therapeutics targeting SARS-CoV-2 replication. (Collaborating institute ICGEB) 2020-2023

Recipient of: 

  • HIVR4P Travel award 2018 to present poster at Madrid, Spain. 
  • 16th European AIDS Conference poster award, Milan 2017. 
  • HIVR4P Travel award 2016 to present poster at 17–21 October in Chicago, Illinois, USA. 
  • David Bruce Snyder Memorial Award for the year 2011-2012, awarded by Department of Veterinary Medical Sciences, University of Maryland 
  • University of Maryland Block Fellowship from 2010 to 2012 awarded by University of Maryland.
  • Jacob. K Goldhaber Travel Award 2012 to attend The American Association of Avian Pathologists conference, San Diego, CA awarded by University of Maryland.
  • University of Maryland Dean’s Fellowship from 2008 to 2010 awarded by University of Maryland.
  • American Society of Virology 2013 Student Travel Award to present in 32nd Annual Meeting July 20 – 24, 2013 Penn State University, State College, Pennsylvania
  • American Society of Virology 2011 Student Travel Award to present in 30th annual ASV meeting at 30th Annual Meeting University of Minnesota, Twin Cities, Minneapolis campus July 16 - 20, 2011.
  • American Society of Virology 2010 Student Travel Award to present in 29th annual ASV meeting at Montana State University, Bozeman, July 17-21, 2010.
  • University Gold Medal in B.V.Sc & A.H for the year 2001-2002 awarded by Orissa University of Agriculture and Technology, Orissa
  • Dr. Dharmananda Mishra Memorial Gold Medal for highest aggregate mark in Animal Husbandry awarded by Orissa University of Agriculture and Technology, Orissa
  • Dr. Brundaban Samal Memorial Gold Medal for highest-grade point in Animal Nutrition awarded by Orissa University of Agriculture and Technology, Orissa
  • Recipient of Pfizer Medallionto stand first in Bachelor degree in Veterinary Science and Animal Husbandry, 2001-2002.
  • State Girl’s Merit Scholarship for highest rank holder to enter into Veterinary school 1995. awarded by Orissa State Government.