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DR. SUPRATIK DAS, Ph.D.  

Senior Research Scientist
+91-129-2876306  (9540278405)
supratik [at] thsti [dot] res [dot] in
B. Sc., University of Calcutta, India
M. Sc., University of Calcutta, India
M.S., Albert Einstein College of Medicine, USA
Ph.D., Albert Einstein College of Medicine, USA


  • Research Interests
  • Chikungunya molecular virology and antigen/immunogen/antigenic bait development.
  • Developing Dengue platform technologies to support prophylactic and therapeutic strategies.
  • HIV-1 vaccine immunogen development (On hold).

 

Fellowships/Assistantships/Travel Awards

  • Junior Research Fellowship by the University Grants Commission (Government of India) in 1993.
  • Graduate Research Assistantship by Albert Einstein College of Medicine, USA in 1994.
  • SRA (Scientist’s pool scheme) Fellowship by the Council for Scientific and Industrial Research, India in 2009.
  • HIVR4P Meeting Travel Scholarship in 2016

Corresponding Author

Research Articles

23) Das S@

      Taking a re-look at cap-binding signatures of the mRNA cap-binding protein eIF4E orthologues in trypanosomatids.

      Molecular and Cellular Biochemistry 2020 Review

22) Das S@Kumar R, Ahmed S, Parray HA,Samal S

      Efficiently cleaved HIV-1 envelopes: Can they be important for vaccine immunogen design?

      Therapeutic Advances in Vaccines and Immunotherapy 2020; 8: 1-17. Review   

21) Ahmed S, Shrivastava T, Kumar R, Kumar M, Banerjee M, Kumar N, Bansal M,Das S, Samal S

      Design and characterization of a germ-line targeting soluble, native-like, trimeric HIV-1 Env lacking key glycans from the V1V2 loop.

      Biochimica et Biophysica Acta – General Subjects 2020; 1865(1): 129733.

20) Samal S, Srivastava T,Sonkusre P, Rizvi ZA, Kumar R, Ahmed S, Viswakarma P, Yadav N,  Bansal M, Chauhan K, Pokhrel S, Das S, Tambare P, Awasthi A

      Tetramerizing tGCN4 Domain Facilitates Production of Influenza A H1N1 M2e Higher Order Soluble Oligomers that Show Enhanced Immunogenicity In vivo.

      J Biol Chem 2020, 295(42): 14352-14366.

19) Parray HA, Chiranjivi AK, Asthana S, Yadav N, Srivastava T, Mani S, Sharma C, Viswakarma P, Das S, Pindari K, Sinha S, Samal S, Ahmed S, Kumar R

      Identification of an anti-SARS-CoV-2 receptor binding domain (RBD) directed human monoclonal antibody from a naïve semi-synthetic library.

      J Biol Chem202095(36):12814-12821. 

18) Samal S, Bansal M, Das S@

      Method to identify efficiently cleaved, membrane-bound, functional HIV-1 (Human Immunodeficiency Virus-1) envelopes.

      MethodsX (Elsevier) 2019; 6:837-849.

17) Das S@, Bansal M, Bhattacharya J

      Characterization of the membrane-bound form of the chimeric, B/C recombinant HIV-1 Env, LT5.J4b12C. 

      J Gen Virol 2018; 99 (10): 1438-1443. 

16)  Samal S*, Das S*, Boliar S, Qureshi H, Shrivastava T, Kumar N, Goswami S, Bansal M, Chakrabarti BK (*Co-First Author)

       Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain  containing region in their C-

       terminal tail.

       Retrovirology 2018; 15:50.

15) Das S, Boliar S, Samal S, Ahmed S, Shrivastava T, Shukla BN, Goswami S, Bansal M, Chakrabarti BK

       Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with

       properties comparable to membrane-bound BG505.

       Virology 2017; 510:22-28.

14) Das S, Boliar S, Mitra N, Samal S, Bansal M, Koff WC, Chakrabarti BK

       Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly

       neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes.

       Retrovirology 2016; 13:81.

 

13) Boliar S*, Das S*, Bansal M, Shukla BN, Patil S, Shrivastava T, Samal S, Goswami S, King CR, Bhattacharya J, Chakrabarti BK (*Co-First Author)

      An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.

      PLOS One 2015; 10(3): e0122443.         

12) Das S@

      Integrase interactor 1 in health and disease.

      Current Protein and Peptide Science 2015; 16(6):478-490. Review

11)Das S@Banerjee B, Hossain M, Thangamuniyandi M, Dasgupta S, Chongdar N, Kumar GS, Basu G

      Characterization of DNA binding property of the HIV-1 host factor and tumor suppressor protein Integrase Interactor 1 (INI1/hSNF5).

      PLOS One 2013; 8(7): e66581.

10) Biswas A, Mukherjee S, Das S, Shields D, Chow CW, Maitra U.

      Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

      J Biol Chem 2011; 286(4):3129-3138.

9) Das S, Cano J, Kalpana GV.

    Multimerization and DNA binding properties of INI1/hSNF5 and its functional significance.

    J Biol Chem 2009; 284(30):19903-19914.

8) Sorin M*, Cano J*, Das S, Mathew S, Wu X, Davies KP, Shi X, Cheng GS, Ott D, Kalpana GV.(*Equal Contribution)

    Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication.

    PLOS Pathogens 2009; 5(6) e1000463.

7)  Das S, Kalpana GV.

     Reverse Two-hybrid Screening to Analyze Protein-Protein Interaction of HIV-1 Viral and Cellular Proteins.

     Methods in Molecular Biology 2009; 485: 271-293.

6) Foletta VC, Lim MA, Soosairaiah J, Kelly AP, Stanley EG, Shannon M, He W, Das S,  Massague J, Bernard O.

    Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1.

    J Cell Biol 2003; 162(6):1089-1098.

5) Das S, Maitra U.

    Functional significance and mechanism of eIF5-promoted GTP hydrolysis in eukaryotic translation initiation.

    Prog Nucleic Acid Res Mol Biol 2001; 70:207-231. Review

4) Das S, Ghosh R, Maitra U.

    Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.
    J Biol Chem 2001; 276(9):6720-6726.

3)  Das S, Maitra U.

     Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro 

     and in vivo.
     Mol Cell Biol 2000; 20(11):3942-3950.

2) Maiti T*, Das S*, Maitra U. (*Co-First Author)

    Isolation and functional characterization of a temperature-sensitive mutant of the Yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-

    dependent cell-free translation system.
    Gene2000; 244(1-2):109-118.

1) Das S, Maiti T, Das K, Maitra U.

    Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2.

    J Biol Chem 1997; 272(50):31712-31718. 

Corresponding Author

 

Books

Das STowards a HIV Vaccine: Biology, Progress and Challenges Scholars’ Press, SIA OmniScriptum Publishing 2018; ISBN-13: 978-620-2-30940-0. Book

  • Translational Research Consortium for Establishing Platform Technologies to Support Prophylactic and Therapeutic Strategies for Dengue - Discovery to Proof-of-Concept (NBM-BIRAC, 2019-2023). Co-investigator

Reviewer

Medicinal Chemistry (2020-  )

VirusDisease (2015-

Group Members (NBM-BIRAC Dengue Project)

Adarsh Chiranjivi (Research Associate)

Ph.D. IIT, Guwahati

 

Gaurav Kumar Singh (M.Sc. Trainee)

Jamia Milia Islamia