People : Scientific : Faculty & Scientists

DR. YASHWANT KUMAR, Ph.D 

Scientist C
+91-129-2876496 
y.kumar [at] thsti [dot] res [dot] in
Postdoc, Weizmann Institute of Science, Israel
PhD, National Chemical Laboratory, India
M.Sc., University of Pune

Metabolomics research has benefited significant fractions of research investigation focused on understanding, diagnosing and preventing human disease. Large number of potential biomarker has been discovered using metabolomics and many of them has been tested for translational applications.  Our research focus on discovery of new biomarker in disease condition using multivariate data analysis and machine learning approaches. This approach can be step forward in disease diagnostics, future prediction and prognosis for any disease condition. At present, using high-resolution mass spectrometer with tandem (MS/MS) and sequential MS/MS (MSn) capability we are trying to measure the whole set of metabolites and lipids in a diabetic condition. We work on whole pipeline from experiment design, sample preparation, analysis, data processing and bioinformatics. Additionally we are also working on determine the structure of metabolic pathway and flux in diseased condition using stable isotope.

1. Kumar Y, Zhang L, Panigrahi P, Dholakia BB, Dewangan V, Kadoo NY, Giri AP, Tang H, Gupta VS (2016) Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics. Plant Biotech J 10.1111/pbi.12522 

2. Kumar Y, Dholakia BB, Panigrahi P, Kadoo NY, Giri AP, Gupta VS (2015) Metabolic profiling of chickpea-Fusarium interaction identifies differential modulation of disease resistance pathways. Phytochemistry 116:120-129 

 

1. Sonu Kumar Gupta

2. Neema Bisht