People : Scientific : Faculty & Scientists

DR. TRIPTI SHRIVASTAVA, Ph.D. 

Scientist
+91-129-2876331 
tripti [at] thsti [dot] res [dot] in
Scientist, IAVI - HIV Vaccine Translational Research Laboratory (HVTR), Translational Health Science and Technology Institute (THSTI), India (2013 - onwards)
Research Associate, Structural Biology, UNMC, NE, USA (2012-2013)
Postdoc Research Associate, Structural Biology, UNMC, NE, USA (2009-2012)
Ph. D, Structural Biology, CDRI, Lucknow/JNU, New Delhi, India (2003-2009)
Ad-hoc Lecturer (Department of Biochemistry), C.S.J.M. University, Kanpur, India (2002-2003)
M. Sc, Biochemistry, C.S.J.M. University, Kanpur, India (2000-2002)

Research Interests/ Research Summary

  • Identification and characterization of HIV envelop surface exposed areas to be used as immunogen for successful vaccine development
  • Designing of native trimeric HIV Env as candidate vaccine.

Awards and prize

  • “Dr D. L. Shrivastava” Young Scientist Award, Society of Biological Chemistry, India (2008)

 

Publications

  • Association of mutations in V3C3 domain with shift in evasion of HIV-1 clade C from follow up broadly neutralizing contemporaneous plasma antibodies in an elite neutralizer. Suprit Deshpande*, Shilpa Patil*, Rajesh Kuma*, Tripti Shrivastava et al. Retrovirology. 2016; 13: 41. doi:  10.1186/s12977-016-0273-x
  • Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in V1 Loop. Shilpa Patil¶, Rajesh Kumar¶, Suprit Despande¶, Sweety Samal, Tripti Shrivastava, Saikat Boliar, et al.Journal of Virology. 2016 Jan 13. pii: JVI.03090-15
  • An efficiently cleaved and native-conformation HIV-1 clade C Env that selectively binds to neutralizing antibodies. Saikat Boliar*, Supratik Das*, Manish Bansal, Brihaspati N Shukla, Shilpa Patil, Tripti Shrivastava, Sweety Samal, Sandeep Ghoswami, Richter C King, Jayanta Bhattacharya and Bimal K Chakrabarti. PLoS One, 2015 Mar 30; 10 (3):e0122443. doi: 10.1371/journal.pone.0122443
  • Structural basis of Ets1 activation by Runx1. Tripti Shrivastava, Nigar Babayeva, Oxana Baranosky, Tahir H Tahirov. Nature - Leukemia, 2014 Oct; 28(10):2040-8.
  • Three-Dimensional Structures of DNA-Bound Transcriptional Regulators, Tripti Shrivastava and Tahir H. TahirovMethods in Molecular Biology, 2010;674:43-55. Review
  • Ligand-Induced Structural Transitions, Mutational Analysis, and ‘Open’ Quaternary Structure of the M. tuberculosis Feast/Famine Regulatory Protein (Rv3291c). Tripti Shrivastava, Abhishek Dey and Ramachandran, Ramachandran. Journal of MolecularBiology2009, 392, 1007–1019
  • Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv. Tripti Shrivastava and Ravishankar Ramachandran. Nucleic Acid Research2007, 35 (21): 7324-35
  • Cloning, expression, purification and crystallization of a transcriptional regulatory protein (Rv3291c) from Mycobacterium tuberculosis H37Rv, Tripti Shrivastava,S. K. Srivastava, and Ravishankar RamachandranActa Crystallograph Sect D Biological crystallography, 2004, D 60, 1874 – 76

 

  • Shuja S. Malik and Tripti Shrivastava. Protein characterization using modern biophysical techniques. Advances in Protein Chemistry, OMICS Group Incorporation

·         CLEAVED FUNCTIONAL CLADE C ENVELOPE GLYCOPROTEIN (USA) WIPO Patent Application WO/2016/065252

  • 2016    Travel Award for HIV R4P 2016, Chicago, USA
  • 2008    “Dr D. L. Shrivastava” Young Scientist Award, Society of Biological Chemistry, India.
  • 2007    Best Publication Award, Central Drug Research Institute, Lucknow, India.
  • 2005    Senior Research Fellowship from Council of Scientific and Industrial Research, India.
  • 2003    Graduate Aptitude Talent Examination (GATE, 98.52 Percentile)
  • 2002    Junior Research Fellowship from Council of Scientific and Industrial Research, India.
  • 2001    Cleared eligibility for lectureship from Council of Scientific and Industrial Research, India.

PDB DEPOSITION

  • 2IVM- Crystal structure of a transcriptional regulator
  • 2VC1, 2VC0, 2VBZ, 2VBY, 2VBX, 2VBW, 2W24 - Feast or famine regulatory protein (Rv3291c) from M. Tuberculosis complexed with amino acids
  • 2W25, 2W29 - Crystal structure of mutant Protein (Glu104Ala and Gly102Thr)
  • 4L0Y, 4L0Z, 4L18- Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1, 2 & 3) 

 

MEMBERSHIP OF PROFESSIONAL ORGANIZATION

  • Life Member of Indian Crystallographic Association (ICA) (LM 609)