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DR. SWEETY SAMAL, Ph.D 

Scientist
+91-129-2876308 
sweety.samal [at] thsti [dot] res [dot] in
Ph.D in Virology from University of Maryland, College Park, 2012
M.V.Sc. in Virology & Bacteriology from Orissa University of Agriculture and Technology, 2007
B.V.Sc

Research Interests/ Research Summary

 My current research focuses on characterization of HIV-1 virus circulating strains to facilitate in designing of both membrane-bound and soluble envelop -based immunogens, mapping immune specificities in Indian population and  establishment of high throughput neutralization assays that will benefit  the evaluation of vaccine candidates, anti-viral drug screening and monoclonal antibodies.My long standing research interest is to carry out innovative scientific research on viral agents leveraging on the expertise gained from HIV and others, thus creating a ' translational virology platform'.

                                                                                          
 

Fellowship and Membership of Professional Bodies

  • University of Maryland Block Fellowshipfrom 2010 to 2012.
  • University of Maryland Dean’s Fellowshipfrom 2008 to 2010.

Professional Affiliations

  • Member of the American society of virology (ASV)
  • Life member of the Indian Virological Society
  • Associate member of American association of avian pathologists (AAAP/AVMA)
  • Member of European AIDS Clinical Society (EACS) 

Membership of Editorial Boards

  • Reviewer for Indian Journal of Virology
  • Reviewer for Plos One

Publications/Book Chapters /Others

  1. Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail.Sweety Samal; Supratik Das; Saikat Boliar; Huma Qureshi;Tripti Shrivastava; Naresh Kumar; Sandeep Goswami; Manish Bansal; Bimal Chakrabarti,Retrovirology,July 2018
  2. Envelope proteins of  two HIV-1 clades induced different epitope-specific antibody responseTripti Shrivastava a,1 , Sweety Samal a,1 , Ashish K. Tyagi , Sandeep Goswami  , Naresh Kumar , Gabriel Ozorowski , Andrew B. Ward  , Bimal K. Chakrabarti . Vaccine 2018 , Equal first co-author.
  3. Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with properties comparable to membrane-bound BG505. Das S, Boliar S, Samal S, Ahmed S, Shrivastava T, Shukla BN, Goswami S, Bansal M, Chakrabarti BK.Virology. 2017 Oct;510:22-28. doi: 10.1016/j.virol.2017.07.001. Epub 2017 Jul 6.PMID: 28689085
  4. Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes.Das S, Boliar S, Mitra N, Samal S, Bansal M, Koff WC, Chakrabarti BK.,Retrovirology. 2016
  5. Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop.Patil S, Kumar R, Deshpande S, Samal S, Shrivastava T, Boliar S, Bansal M, Chaudhary NK, Srikrishnan AK, Murugavel KG, Solomon S, Simek M, Koff WC, Goyal R, Chakrabarti BK, Bhattacharya J.J Virol. 2016 Jan 13
  6. An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.Boliar S, Das S, Bansal M, Shukla BN, Patil S, Shrivastava T, Samal S, Goswami S, King CR, Bhattacharya J, Chakrabarti BK.PLoS One. 2015 Mar 30
  7. Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus.Khattar SK, Palaniyandi S, Samal S, LaBranche CC, Montefiori DC, Zhu X, Samal SK.Hum Vaccin Immunother. 2015
  8.  Effects of naturally occurring six- and twelve-nucleotide inserts on Newcastle disease virus replication and pathogenesis.Paldurai A, Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, Samal SK.PLoS One. 2014 Aug 5
  9. Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques.Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK.PLoS One. 2013 Oct 10
  10. Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector.Khattar SK, Samal S, LaBranche CC, Montefiori DC, Collins PL, Samal SK.PLoS One. 2013 Oct 1;8(10):e78521. doi: 10.1371/journal.pone.0078521. eCollection 2013. Erratum in: PLoS One. 2014;
  11.  Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity.Samal S, Khattar SK, Paldurai A, Palaniyandi S, Zhu X, Collins PL, Samal SK.J Virol. 2013 Sep.
  12.  Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity.Samal S, Khattar SK, Kumar S, Collins PL, Samal SK.J Virol. 2012 Mar
  13. Newcastle disease virus expressing human immunodeficiency virus type 1 envelope glycoprotein induces strong mucosal and serum antibody responses in Guinea pigs.Khattar SK, Samal S, Devico AL, Collins PL, Samal SK.J Virol. 2011 Oct
  14. A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity.Samal S, Kumar S, Khattar SK, Samal SK.J Gen Virol. 2011 Oct; 
  • Improved Newcastle disease virus as vaccine and oncolytic agent (U.S provisional patent application number 61/860025).The invention has been marketed to company AVIMAX,USA 
  • NATIVE TRIMERIC ENV IMMUNOGEN DESIGN (USA), WIPO Patent Application WO/2016/065252

Recipient of: 

  • 16th European AIDS Conference poster award, Milan 2017. 
  • HIVR4P Travel award 2016 to present poster at 17–21 October in Chicago, Illinois, USA. 
  • David Bruce Snyder Memorial Award for the year 2011-2012, awarded by Department of Veterinary Medical Sciences, University of Maryland 
  • University of Maryland Block Fellowship from 2010 to 2012 awarded by University of Maryland.
  • Jacob. K Goldhaber Travel Award 2012 to attend The American Association of Avian Pathologists conference, San Diego, CA awarded by University of Maryland.
  • University of Maryland Dean’s Fellowship from 2008 to 2010 awarded by University of Maryland.
  • American Society of Virology 2013 Student Travel Award to present in 32nd Annual Meeting July 20 – 24, 2013 Penn State University, State College, Pennsylvania
  • American Society of Virology 2011 Student Travel Award to present in 30th annual ASV meeting at 30th Annual Meeting University of Minnesota, Twin Cities, Minneapolis campus July 16 - 20, 2011.
  • American Society of Virology 2010 Student Travel Award to present in 29th annual ASV meeting at Montana State University, Bozeman, July 17-21, 2010.
  • University Gold Medal in B.V.Sc & A.H for the year 2001-2002 awarded by Orissa University of Agriculture and Technology, Orissa
  • Dr. Dharmananda Mishra Memorial Gold Medal for highest aggregate mark in Animal Husbandry awarded by Orissa University of Agriculture and Technology, Orissa
  • Dr. Brundaban Samal Memorial Gold Medal for highest-grade point in Animal Nutrition awarded by Orissa University of Agriculture and Technology, Orissa
  • Recipient of Pfizer Medallionto stand first in Bachelor degree in Veterinary Science and Animal Husbandry, 2001-2002.
  • State Girl’s Merit Scholarship for highest rank holder to enter into Veterinary school 1995. awarded by Orissa State Government.