People : Scientific : Faculty & Scientists

DR. SUPRIT DESHPANDE, M.Sc.,M.Phil.,Ph.D., 

Scientist
+91-129-3087329 
supritd [at] thsti [dot] res [dot] in
Ph.D., Gulbarga University, Kalaburgi
M.Phil.,(Medical Microbiology) Gulbarga University, Kalaburgi
M.Sc.,(Microbiology) Gulbarga University, Kalaburgi

Work Experiences:

Current Position (Since 14 July 2016): Scientist                           

My Current research focus is on generation and characterization of HIV-1clade C functional envelopes from broadly neutralizing plasmas from Indian Donors  and Isolation and Characterization of Human Monoclonal Antibodies from Broadly Cross Neutralizing HIV-1 Clade C infected patients. 

 

2015 – July 2016: Postdoctoral Fellow                                               Organization: THSTI, Faridabad

 “Characterization of HIV-1 Primary envelopes obtained from broadly cross neutralizing plasma for their degree of cleavage, sensitivity to neutralizing and non neutralizing antibodies and immunogenicity" funded by Dept of Biotechnology, Govt. of India

PI: Dr. Jayanta Bhattacharya

 

2013-2014: Research Associate                                                          Organization: THSTI, Faridabad

“Identification of neutralizing antibody epitopes from Indian and South African HIV-1 subtype C for the vaccine design” funded by the Dept of Science & Tehnology, Govt.of India

PI: Dr. Jayanta Bhattacharya / Prof Lynn Morris

 

2012-2013: Research Associate                                                          Organization: National AIDS Research Institute, Pune

Role of miRNAs in HIV/AIDS pathogenesis”funded by the Deptof Biotechnology, Govt of India.

PI: Dr Shahid Jameel, ICGEB, New Delhi/Dr. Raman. Gangakhedkar . NARI, Pune

 

2008-2012: Research Associate                                                          Organization: National AIDS Research Institute, Pune

“Neuro AIDS in India”NIH funded Indo-US collaborative Research Project.

PI: Dr. T Marcotte, UCSD, San Diego/ Dr. S. Mehendale NARI, Pune

 1. Kumar, R., Ozorowski, G., Kumar, V., Holden, L., Shrivastava, T., Patil, S., Deshpande, S., Ward, A.B., Bhattacharya.J. (2017). Characterization of a  stable HIV-1 B/C recombinant, soluble and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes. Journal of  Biological Chemistry.Jul 25. pii: jbc.M117.803056. doi: 10.1074/jbc.M117.803056

 2.  Suprit Deshpande, Shilpa Patil, Rajesh Kumar, Tripti Shrivastava, Aylur K. Srikrishnan, Kailapuri G. Murugavel, Wayne C. Koff,  Bimal K.  Chakrabarti, Jayanta Bhattacharya. (2016). Association of mutations in V3/C3 domain with enhanced sensitivity of HIV-1 clade C primary    envelopes to autologous broadly neutralizing plasma antibodies. Retrovirology 13: 41

3.  Despande, S., Patil, S., Kumar, R., Hermanus, T., Murugavel, K.G., Solomon, S., Morris, L., Bhattacharya, J*.(2016) HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms. Retrovirology30;13(1):60

4. Patil, S*., Kumar, R*., Deshpande, S*., Samal, S., Shrivastava, T., Boliar, S., Bansal, M., Chaudhary, N.K., Srikrishnan, A.K., Murugavel, K.G., Solomon, S., Simek, M., Koff, W.C., Goyal, R., Chakrabarti, B.K., Bhattacharya, J.(2016). Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C Infected Elite Neutralizer Mediate Autologous Virus Escape through Novel Mutations in V1 Loop. Journal of Virology 90 (7):3446-3457. (* Co first author )

5. Tilghman MW , Bhattacharya J., Deshpande S, Ghate M, Espitia S, Grant I, Marcotte TD, Smith D, Mehendale S. (2014). Genetic attributes of blood-derived subtype-C HIV-1 tat and env in India and neurocognitive function. J Med Virol. 86(1): 88-96

1.       HIV-1 CLADE C ENVELOPE GLYCOPROTEINS: US provisional Patent application 62/189,418 filed on 7th July 2015

United States Patent Application 

 Inventors: Jayanta Bhattacharya, Suprit Deshpande, Shilpa Patil, Rajesh Kumar, Bimal K. Chakrabarti

2.       ISOLATED NUCLEOTIDE SEQUENCE USEFUL FOR THE PREVENTION OF HIV-1 INFECTION 

India # 201611004727 (Indian Provisional Patent) Filed: February 10, 2016

 Inventors: Jayanta Bhattacharya, Suprit Deshpande, Shilpa Patil, Rajesh Kumar, Bimal K. Chakrabarti.

  • 2016    Travel Grant Award for attending HIV R4P2016, Chicago, USA
  • JRF & SRF award from Gulbarga University, Kalaburgi as a Meritorious Research fellow.