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DR. SHUBBIR AHMED, PhD  

Senior Scientist
+91-129-2876335 
sahmed [at] thsti [dot] res [dot] in
Staff Scientist, Drug Discovery and Structural Biology Core Facility. Beckman Research Institute, City of Hope, Duarte, California, USA.
Research Associate. Beckman Research Institute, City of Hope, Duarte, California, USA.
Research Associate. University of Southern California (USC), Keck School of Medicine, Department of Medicine, Los Angeles, California, USA.
Ph.D. Institute of Microbial Technology (IMTECH), Chandigarh, India.


Design, engineering and biochemical/biophysical characterization of antigens and antibodies for infectious diseases.

Pubmed search: shubbir ahmed, http://www.ncbi.nlm.nih.gov/pubmed?term=shubbir%20ahmed)

  1. Ahmed S*, Shrivastava T, Kumar N, Ozorowski G, Ward AB, Chakrabarti BK* (2017). Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein. J Biol Chem. 292(20):8236-43. *Co-corresponding authors.
  2. Das S, Boliar S, Samal S, Ahmed S, Shrivastava T, Shukla BN, Goswami S, Bansal M, Chakrabarti BK. (2017) Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with properties comparable to membrane-bound BG505. Virology510(6):22-28.
  3. Yan S, Zhang H, Hou G, Ahmed S, Williams JC, Polenova T. (2015S) Internal Dynamics of Dynactin's CAP-Gly is Regulated by Microtubules and Plus End Tracking Protein EB1. J Biol Chem. 290(3):1607-22. 
  4. Chandrayan SK, Prakash S, Ahmed S, Guptasarma P. (2014)Hyperthermophile Protein Behavior: Partially-Structured Conformations of Pyrococcus furiosus Rubredoxin Monomers Generated through Forced Cold-Denaturation and Refolding.PLoS One 9(3):e80014.
  5.  Ahmed S,Xie, J, Horne, D and Williams JC. (2014) Photocleavable Dimerizer for the Rapid Reversal of Molecular Trap Antagonists. J Biol Chem 289(8):4546-52. (Report)
  6. Yan, S, Hou, G, Schwieters, CD, Ahmed S, Williams, JC, Polenova T. (2013) Three-Dimensional Structure of CAP-Gly Domain of Mammalian Dynactin Determined by Magic Angle Spinning NMR Spectroscopy: Conformational Plasticity and Interactions with End Binding Protein EB1. J Mol Biol 425(22):4249-69.
  7. Stuchell-Brereton MD, Siglin A, Li j, Moore JK, Ahmed S,Williams JC, Cooper JA. (2011) Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Mol Biol Cell 22(15):2690-701.
  8. Ahmed S, Sun S, Siglin AE, Polenova T, Williams JC. (2010) Disease-associated mutations in the p150Glued subunit destabilize the CAP-gly domain. Biochemistry 49(25):5083-5. (Rapid Report)
  9. Ahmed S,Guptasarma P. (2008) Design of a soluble mini-protein through tandem duplication of the minimally engineered beta hairpin 'tongue' motif of alpha-hemolysin. Biochimie90(6):957-67.
  10. Ahmed S, Shukla A, Guptasarma P. (2008) Folding behavior of a backbone-reversed protein: Reversible polyproline type II to beta-sheet thermal transitions in retro-GroES multimers with GroES-like features. Biochim Biophys Acta.–Proteins and Proteomics1784(6):916-23.
  11. Ahmed S, Kapoor D, Singh B, Guptasarma P. (2008) Conformational behavior of polypeptides derived through simultaneous global conservative site-directed mutagenesis of chymotrypsin inhibitor 2. Biochim Biophys Acta.-Proteins and Proteomics1784(5):796-805.
  12. Kapoor D, Kumar V, Chandrayan SK, Ahmed S,Sharma S, Dutt M, Singh B, Karthikeyan S, Guptasarma P. (2008) Replacement of the active surface of a thermophile protein by that of a homologous mesophile protein through structure-guided 'protein surface grafting. Biochim Biophys Acta.-Proteins and Proteomics 1784(11):1771-6.
  13. Kapoor D, Kumar S, Ahmed S,Guptasarma P. (2007) Using DNA sequencing electrophoresis compression artifacts as reporters of stable mRNA structures affecting gene expression. Electrophoresis28(21):3862-7.
  14. Das U, Hariprasad G, Ethayathulla AS,Manral P, Das TK, Pasha S, Mann A, Ganguli M, Verma AK, Bhat R, Chandrayan SK, Ahmed S, Sharma S, Kaur P, Singh TP, Srinivasan A. (2007) Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key. PLoS One2(11):e1176.

1.      US provisional patent submitted

Title: Stabilized Indian Clade C ENV. Shubbir Ahmed, Tripti Shrivastava and Bimal Chakrabarti. (US Provisional Patent Application No. 62/407,729)

 

2.      US patent Submitted

Title:Photoclevable Linker. John C. Williams, David Horne, Jun Xie and Shubbir Ahmed. (US Patent Application No. 2014015477)

 

3.      US, EP and India patent approved

Title:A recombinant meso-active thermo-stable protein and the process of design and biosynthesis thereof. Divya Kapoor, Sanjeev Kumar, Shubbir Ahmed, Swati Sharma, Manish Dutt, Balvinder Singh, Karthikeyan Subramanian and Purnananda Guptasarma. (US Patent No. 11/936,009, EP patent No. 2099820, India Patent No. 2411/DEL/2006)

  • Department of Biotechnology & Department of Science & Technology (under Indo-South Africa joint proposal). Isolation and Characterization of Monoclonal Antibodies from HIV-1 Subtype C Infected Individuals. Role: Co-Principal Investigator (India) (PI: Jayanta Bhattacahrya): AWARDED Year: December 2017. Total Awarded Amount: INR 2,04,64,636.
  • BIRACfundedTranslational Research Consortium for Establishing Platform Technologies to Support Prophylactic and Therapeutic Strategies for Dengue Discovery to Proof-of-Concept” under Industry-Academia Collaborative Mission for Accelerating Discovery Research to Early Development For Biopharmaceuticals - “Innovate in India (i3) Empowering biotech entrepreneurs & accelerating inclusive innovation” for 2019-2023. Role: Co-Principal Investigator.

HONORS AND AWARDS

  • Recipient of  full scholarship and travel award to attend ‘HIV Research for Prevention 2018: (HIVR4P) conference held at Spain, Madrid, Oct., 2018
  • Recipient for full scholarship and travel award to attend ‘HIV Research for Prevention 2016: (HIVR4P) conference held at Chicago, USA, Oct., 2016
  • Bagged 2nd prize for project development in technological entrepreneurship workshop hosted jointly by Indian Institute of Management, Bangalore (IIMB) and CSIR, 2005.2
  • Council for Scientific and Industrial Research - Senior Research fellowship (CSIR-SRF), Govt. of India, 2004.7 - 2007.7
  • Council for Scientific and Industrial Research - Junior Research fellowship (CSIR-JRF), Govt. of India, 2002.6-2004.6
  • Nominated for CSIR-SPM Fellowship Exam. (top 20% among CSIR-NET qualifier), 2002
  • Graduate Aptitude Test for Engineering (GATE), 2001. 
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