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People : Scientific : Faculty & Scientists

PROF. SHINJINI BHATNAGAR, PhD 

Dean (clinical Research), Head-pbc, Coordinator-cbd
+91-129-2876351  (+91-129-2876351)
shinjini.bhatnagar [at] thsti [dot] res [dot] in
Ph.D. (Pediatrics), All India Institute of Medical Sciences, New Delhi
Diplomate National Board (MD Pediatrics), All India Institute of Medical Sciences, New Delhi
MBBS, Lady Hardinge Medical College, University of Delhi

Present Research Interest

As a Senior Research Scientist and Pediatric Gastroenterologist at the Centre for Diarrheal Diseases and Nutrition Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, we conducted hypothesis driven studies that evaluated interventions directed at host responses in morbidity related to infections. Our research was primarily to facilitate evidence based recommendations in child health for global and national policy; algorithm for treatment of persistent diarrhea, low osmolarity oral rehydration salts solution and zinc in treatment of diarrhea. We participated in developing the clinical and research discipline of Pediatric Gastroenterology at AIIMS.

Current Research Interest

The predominant direction of our research is to conduct hypothesis driven and hypothesis generating studies that will facilitate development of knowledge based interventions and public health tools for child health. The broad focus is in the domain of molecular mechanistic causality of neonatal and infant infections particularly with reference to host responses and the potential interventions. Components of the immune system may be permanently programmed by events in fetal and early peri-or neonatal life which would have post-natal consequences. In order to study this hypothesis further we are doing immunological characterization of cord blood and early infancy, in full-term appropriate- and small-for-gestational age neonates, to examine the status of immune system maturation in a situation of intrauterine growth retardation; we are also evaluating other potential modifiers of the immune system maturation and development. Our other immediate objective is to understand if micronutrient supplementation or modification of the host gut flora can affect the host immune response to vaccines in early post natal life; an important public health issue in our country and other low and middle income settings where the efficacy of oral vaccines is poor.

In India, more than a quarter of the one million neonatal deaths are attributed to serious bacterial infections that include pneumonia, sepsis and meningitis. These severe infections are also a major cause of hospitalization in young infants. The outcomes of these infections in early infancy are poor. Interventions that can immediately improve the efficacy of existing standard therapy of serious bacterial infection in low resource settings are a high priority. We propose to study the biology of serious bacterial infections and evaluate interventions that can influence host responses to infections. As an immediate objective we propose to study the possible effects of micronutrients on host responses in infections amongst young infants.

Poor responses to vaccines in developing countries have impeded attempts at disease eradication or control. An initial program in this domain is to evaluate if micronutrients supplementation or factors that alter intestinal flora influence host immune responses to vaccines given at birth.

Another research focus is to develop diagnostics and low cost health products for childhood diseases. As an initial step in that direction we are developing a rapid in-house point of care test for diagnosis of celiac disease (CD) in partnership with International Centre for Genetic Engineering & Biotechnology, All India Institute of Medical Sciences and an industry.

  • Chaturvedi MK; Sodhi J; Fitzwater SP; Chandra J; Rath B; Kainth US; Saini S; Black RE; Santosham M; Bhatnagar S, Efficacy of oral zinc supplementation in radiologically proven pneumonia: Secondary analysis of a Randomized controlled trial, Bulletin of WHO May, 2017 10.1093/tropej
  • Singh PArora AStrand TASommerfelt HLodha RKabra SKAneja SNatchu UCMChandra JRath BKumar Sharma VKumari MSaini SBhatnagar SWadhwa N. Predictors of death in infants with probable serious bacterial infection. Pediatr Res,2017. 299 (in press)
  • Khullar BBalyan ROswal NJain NSharma AAbdin MZBagga ABhatnagar SWadhwa NNatchu UCMGeorge ARath SBal VSopory S. Interaction of CD80 with Neph1: A potential mechanism of podocyte injury.Clin Exp Nephrol. 2017 Oct 11. doi: 10.1007/s10157-017-1489-3.
  • Anthwal D; Gupta RK; Bhatnagar S; Tyagi JS; Haldar S; Bhalla M Direct detection of Rifampicin and Isoniazid resistance in sputum samples from tuberculosis patients by High Resolution Melt curve analysis Journal of Clinical Microbiology March, 2017 10.1128/JCM.02104-16 
  • Prabhu SB; Rathore DK; Nair D; Chaudhary A; Raza S; Kanodia P; Sopory S; George A; Rath S; Bal V; Tripathi R; Ramji S; Batra A; Aggarwal KC; Chellani HK; Arya S; Agarwal N; Mehta U; Natchu UC; Wadhwa N; Bhatnagar S. Comparison of Human Neonatal and Adult Blood Leukocyte Subset Composition Phenotypes PLoS One Sep, 2016 10.1371/journal.pone.0162242
  • Yoshida S, Martines J, Lawn JE, Wall S, Souza JP, Rudan I, Cousens S; neonatal health research priority setting group, Aaby P, Adam I, Adhikari RK, Ambalavanan N, Arifeen SE, Aryal DR, Asiruddin S, Baqui A, Barros AJ, Benn CS, Bhandari V, Bhatnagar S, et al,. Setting research priorities to improve global newborn health and prevent stillbirths by 2025. J Glob Health 2016, Jun;6(1):010508.
  • Bag S; Saha B; Mehta O; Anbumani D; Kumar N; Dayal M; Pant A; Kumar P; Saxena S; Allin KH; Hansen T; Arumugam M; Vestergaard H; Pedersen O; Pereira V; Abraham P; Tripathi R; Wadhwa N; Bhatnagar S; Prakash VG; Radha V; Anjana RM; Mohan V; Takeda K; Kurakaw An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples, Scientific Reports May, 2016 10.1038/srep26775 
  • Kumar N; Gupta DG; Kumar S; Maurya P; Tiwari A; Mathew B; Banerjee S; Haldar S; Pillai J;  Bhatnagar S; Chaudhuri S, Exploring Packaged Microvesicle Proteome Composition of Chinese Hamster Ovary Secretome Journal of Biotechnology and Bioprocess Engineering April, 2016 10.4172/2155-9821.1000274 
  • Sharma C, Sankhyan A, Sharma T, Khan N, Chaudhuri S, Kumar N, Bhatnagar S, Khanna N, Tiwari A. 2015. A repertoire of high-affinity monoclonal antibodies specific to S. typhi: as potential candidate for improved typhoid diagnostic. Immunol Res; 62(3):325-40.
  • Chaudhuri S; Maurya P; Kaur M; Tiwari A; Borth A;  Bhatnagar S; Kumar N,  Investigation of CHO Secretome: Potential Way to Improve Recombinant Protein Production from Bioprocess J Bioprocess Biotech July, 2015 10.4172/2155-9821.1000240 
  • Singh P and Wadhwa N, Lodha R, Sommerfelt H, Aneja S, Natchu UCM, Kabra SK, Bhatnagar S#, Strand TA. 2015. Predictors of time till recovery in infants with probable serious bacterial infections. PlosONE; 10(4):e0124594.
  • Rathore DK, Nair D, Raza S, Saini S, Singh R, Kumar A, Tripathi R, Ramji S, Batra A, Aggarwal KC, Chellani HK, Arya S, Bhatla N, Paul VK, Aggarwal R, Agarwal N, Mehta U, Sopory S, Natchu UCM, Bhatnagar S, Bal V, Rath S, Wadhwa N. 2015.Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype. PlosONE; 10(4):e0123589.  
  • Singh P, Wadhwa N, Chaturvedi MK, Bhatia V, Saini S, Tandon N, Makharia GK, Maki M, Not T, Phillips A, Bhatnagar S. 2014. Validation of point-of-care testing for coeliac disease in children in a tertiary hospital in north India. Arch Dis Child; 99(11):1004-8.
  • Lodha R, Mukherjee A, Singh V, Singh S, Friis H, Faurholt-Jepsen D, Bhatnagar S, Saini S, Kabra SK, Grewal HM; Delhi Pediatric TB Study Group. 2014. Effect of micronutrient supplementation on treatment outcomes in children with intrathoracic tuberculosis: a randomized controlled trial. Am J Clin Nutr; 100(5):1287-97.
  • Prasad K, Sharma A, Garg A, Mohanty S, Bhatnagar S, Johri S, Singh KK, Nair V, Sarkar RS, Gorthi SP, Hassan KM, Prabhakar S, Marwaha N, Khandelwal N, Misra UK, Kalita J, Nityanand S; InveST Study Group. 2014. Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke; 45(12):3618-24.
  • Negi R, Dewan P, Shah D, Das S, Bhatnagar S, Gupta P. 2014. Oral zinc supplements are ineffective for treating acute dehydrating diarrhoea in 5-12-year-olds. Acta Paediatr; Mar 28.
  • Lodha R, Shah N, Mohari N, Mukherjee A, Vajpayee M, Singh R, Singla M, Saini S, Bhatnagar S, Kabra S. 2014. Immunologic effect of zinc supplementation in HIV infected children receiving highly active antiretroviral therapy: A randomized, double blind placebo controlled trial. J Acquir Immune Defic Syndr; 66(4):386-92.
  • Mukherjee A, Saini S, Kabra SK, Gupta N, Singh V, Singh S, Bhatnagar S, Saini D, Grewal HM, Lodha R; Delhi TB Study group, Aneja S, Arya T, Bhatnagar S, Chandra J, Dutta A, Doherty T, Friis H, Grewal HM, Hesseling A, Kabra S, Lodha R, Marais B, Mukherjee A, Parashar D, Prajapati S, Purohit K, Saini D, Saini S, Singh RR, Singh S, Singh V. 2014. Effect of micronutrient deficiency on QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood intrathoracic tuberculosis. Eur J Clin Nutr; 68(1):38-42.
  • Wadhwa N, Chandran A, Aneja S, Lodha R, Kabra SK, Chaturvedi MK, Sodhi J, Fitzwater SP, Chandra J, Rath B, Kainth US, Saini S, Black RE, Santosham M, Bhatnagar S#. 2013. Efficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2-24 mo of age: a randomized, double-blind, placebo-controlled trial.Am J Clin Nutr; 97(6):1387-94
  • Natchu UCM,Bhatnagar S#.2013. Diarrhoea in children: identifying the cause and burden.Lancet; 13:S0140-6736(13)60941-1
  • Natchu UC, Bhatnagar S#. 2013. Diarrhoea in children and Cryptosporidium - Authors' reply. Lancet; 382(9904):1552. doi: 10.1016/S0140-6736(13)62322-3.
  • Singh P, Das P, Jain AK, Mathan M, Mathur M, Bhat AS, Varma S, Chaturvedi MK, Gupta SD, Bhatnagar S#. 2013. Microscopic colitis in children with chronic diarrhea.J Pediatr Gastroenterol Nutr; 57(2): 240-4.
  • Bhatnagar S#, Wadhwa N, Aneja S, Lodha R, Kabra SK, Natchu UCM, Sommerfelt H, Dutta AK, Chandra J, Rath B, Sharma M, Sharma VK, Kumari M and Strand TA. 2012. Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: a randomised, double-blind, placebo-controlled trial. Lancet; 379:2072-8
  • Kumar N, Sharma G, Kaur G, Tandon N, Bhatnagar S, Mehra N. 2012. Major histocompatibility complex class I chain related gene-A microsatellite polymorphism shows secondary association with type 1 diabetes and celiac disease in North Indians. Tissue Antigens; 80(4):356-62.
  • Wadhwa N, Natchu UC, Sommerfelt H, Strand TA, Kapoor V, Saini S, Kainth US,Bhatnagar S#. 2011. ORS Containing Zinc Does Not Reduce Duration or Stool Volume of Acute Diarrhea in Hospitalized Children.J Pediatr Gastroenterol Nutr; 53(2):161-7.
  • Arun S, Bhatnagar S, Menon S, Saini S, Hari P, Bagga A. 2009. Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome. Pediatr Nephrol; 24(8):1583-6.
  • Fontaine O, Kosek M, Bhatnagar S, Boschi-Pinto C, Chan KY, Duggan C, Martinez H, Ribeiro H, Rollins NC, Salam MA, Santosham M, Snyder JD, Tsai A,  Vargas B, Rudan I. 2009. Setting Research Priorities to reduce Global Mortality from Childhood Diarrhoea by 2015. PLoS Med; 6:01-6.
  • Kosek M, Lanata CF, Black RE, Walker DG, Snyder JD, Salam MA, Mahalanabis D, Fontaine O, Bhutta ZA, Bhatnagar S, Rudan I.  2009. Directing diarrheal disease research towards disease burden reduction.J Health Popul Nutr; 27(3):319-31.
  • Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M, Mearin ML, Ortigosa L, Phillips A. 2008. Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Report on Celiac Disease. Celiac Disease Working Group.J Pediatr Gastroenterol Nutr; 47:214-219.
  • Behera B, Mirdha BR, Makharia GK, Bhatnagar S, Dattagupta S. 2008. Parasites in patients with malabsorption syndrome: A clinical study in children and adults. Dig Dis Sci; 53(3):672-9.
  • Rachakonda G, Choudekar A, Parveen S, Bhatnagar S, Patwari A, Broor S. 2008. Genetic diversity of norviruses and sapoviruses in children with acute sporadic gastroenteritis in New Delhi, India. J Clin Virol; 43:42-8.
  • Bhatnagar S#, 2007. Effects of zinc supplementation on child mortality. Lancet; 369:885-6.
  • Bhatnagar S#, Aggarwal R. 2007. Lactose intolerance.BMJ; 334:1331-2.
  • Kaur G, Rapthap CC, Kumar S, Bhatnagar S, Bhan MK, Mehra NK. 2006.Polymorphism in L-selectin, E-selectin and ICAM-1 genes inAsian Indian pediatric patients with celiac disease. Hum Immunol; 67(8):634-8.
  • Ray P, Fenaux M, Sharma S, Malik J, Subodh S, Bhatnagar S, Greenberg H, Glass RI, Gentsch J, Bhan MK. 2006. Quantitative evaluation of rotaviral antigenemia in children with acute rotaviral diarrhea. J Infect Dis; 194(5):588-93.
  • Bhan MK, Bahl R, Bhatnagar S. 2005.Typhoid and paratyphoid fever. Lancet; 366:749-62. 
  • Bhatnagar S#, Gupta SD, Mathur M,  Phillips AD, Kumar R, Knutton S, Unsworth J, Lock B, Natchu UC, Mukhopadhyaya S, Saini S, Bhan MK. 2005.Coeliac disease with mild to moderatehistological changes is a common cause of chronicdiarrhea in Indian children. J Pediatr Gastroenterol Nutr; 41:204-209.
  • Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK. 2004. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr; 38(1):34-40.
  • Troncone R, Bhatnagar S, Butzner D, Cameron D, Hill I, Hoffenberg E, Maki M, Mendez V, de Jimenez MZ. 2004. European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Celiac disease and other immunologically mediated disorders of the gastrointestinal tract: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr; 39 Suppl 2:S601-10.
  • Ray P, Malik J, Singh RK, Bhatnagar S, Bahl R, Kumar R, Bhan MK. 2003. Rotavirus Nonstructural Protein NSP4 induces heterotypic antibody response during natural infection in children. J Infect Dis; 187(11):1786-93.
  • Hill I, Bhatnagar S, Cameron DJS, De Rosa S, Maki M, Russell GJ, Troncone R. 2002. Celiac Disease: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr; 35(2):S78-88. 
  • Kaur G, Sarkar N, Bhatnagar S, Kumar S, Rapthap CC, Bhan MK, Mehra NK. 2002. Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. Human Immunol; 63(8):677-82.
  • International Task Force. 2001. Effect of zinc supplementation on clinical course of acute diarrhea.  J Health Popul Nutr; 19:339-46.
  • CHOICE Study GroupBhatnagar S#. 2001. Multicenter, randomized, double-blind clinical trial to evaluate the efficacy and safety of a low osmolarity oral rehydration salts solution in children with acute watery diarrhea. Pediatrics; 107(4):613-8.
  • Bhatnagar S#, Taneja S. 2001. Zinc and cognitive development. Br J Nutr; 85:139-145.
  • Alam NH, Majumdar RN, Fuchs GL & the CHOICE Study Group (Bhatnagar S: member of CHOICE Study Group). 1999.The efficacy and safety of a reduced osmolarity oral rehydration solution in adults with cholera: a randomized double blind clinical trial. Lancet; 354: 296-99.
  • Bhatnagar S, Singh KD, Sazawal S, Saxena SK, Bhan MK. 1998. Efficacy of milk versus yogurt feeding in acute non-cholera diarrhea among malnourished children. J Pediatr; 132:999-1003.
  • Bhatnagar S, Bhan MK, Singh Kiran Deep, Srivastava R. 1996. Prognostic factors in hospitalized children with persistent diarrhoea; implications for diet therapy. J Ped Gastroenterol Nutr; 23:151-158.
  • Bhatnagar S,Bhan MK, Singh Kiran Deep, Saxena SK, Shariff M. 1996. Efficacy of milk based diets in persistent diarrhoea: a randomized controlled trial. Pediatrics; 98:1122-1126.
  • Bhan MK, Bhatnagar S, Singh KD. 1996. Evaluation of the efficacy of an algorithm for the treatment of persistent diarrhoea: A multicentric study. International working group on persistent diarrhoea. Bull WHO; 74:479-89.
  • International Study Group, (Bhatnagar S: Study group authorship) 1995 on reduced osmolarity ORS solutions. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. Lancet; 345:282-285.
  • Sommerfelt H, Bhan MK, Srivastava R, Bhatnagar S. 1993. Evaluation of DNA-DNA hybridization for the direct detection of enterotoxigenic Escherichia coli in stool blots. Scand J Infect Dis; 25:457-63.
  • Bhatnagar S, Bhan MK, George C, Gupta U, Kumar R, Bright DS, Saini S. 1992. Is small bowel bacterial overgrowth of pathogenic significance in persistent diarrhoea? Acta Paed; 81(S381):108S-113S.
  • Bhatnagar S, Bhan MK, Sazawal S, Gupta U, George C, Arora NK, Kashyap DK. 1992. Efficacy of massive dose oral gentamicin therapy in non-bloody persistent diarrhoea with associated malnutrition. J Pediatr Gastroenterol Nutr; 12:117-24.
  • Sazawal S, Bhatnagar S, Bhan MK, Saxena SK, Arora NK, Aggarwal SK, Kashyap D. 1991. Alanine based oral rehydration solution. Assessment of efficacy in acute non-cholera diarrhoea among children. J Pediatr Gastroenterol Nutr; 12(4):461-8.
  • Sazawal S, Bhan MK, Bhandari N, Clemens J, Bhatnagar S. 1991. Evidence for recent diarrhoeal morbidity as a risk factor for persistent diarrhoea: A case control study. Int J Epidemiol; 20:540-5.
  • Bhan MK, Sazawal S, Bhatnagar S, Bhandari N, Guha DK, Aggarwal SK. 1990. Glycine, Glycyl-Glycine and Maltodextrin based oral rehydration solution: Assessment of efficacy and safety in comparison to standard ORS. Acta Pediatr Scand; 79:518-26.
  • Bhandari N, Bhan MK, Sazawal S, Clemens JD, Bhatnagar S, Khoshoo V. 1989. Association of antecedent malnutrition with persistent diarrhoea. A case control study. BMJ; 298:1284-7.
  • Khoshoo V, Bhatnagar S, Bhan MK. 1989. Monosaccharide intolerance complicating protracted diarrhoea in infancy. J Pediatr Gastroenterol Nutr; 9:131-4.
  • Bhan MK, Khoshoo V, Puri S, Jain R, Jayashree S, Bhatnagar S. 1989. Serum anti gliadin antibody profile in childhood protracted diarrhoea due to coeliac disease and other causes in developing country. Scand J Gastroenterol;24:1212-6.
  • Bhan MK, Arora NK, Khoshoo V, Raj P, Bhatnagar S, Sazawal S, Sharma K. 1988. Comparison of a lactose free cereal based formula and cow's milk in infants and children with acute gastroenteritis. J Pediatr Gastroenterol Nutr;7:208-13.
  • Bhan MK, Ghai OP, Khoshoo V, Vasudev AS, Bhatnagar S, Arora NK, 1987. Efficacy of lentil and pop rice based rehydration solution in comparison with standard glucose electrolyte solution. J Pediatr Gastroenterol Nutr; 6:392-9.

National

  • Yadav P, Khalil S, Mirdha BR, Makharia GK, Bhatnagar S. 2015. Molecular characterization of clinical isolates of Cyclospora cayetanensis from patients with diarrhea in India. Indian J Med Microbiol; 33(3):351-6.
  • Bothra M, Bhatnagar S. 2015. Probiotics in pediatrics. Indian J Pediatr; 82(5):399-400.
  • Khandelwal D, Gupta N, Mukherjee A, Lodha R, Singh V, Grewal HM, Bhatnagar S, Singh S, Kabra SK; Delhi Pediatric TB Study Group. 2014. Vitamin D levels in Indian children with intrathoracic tuberculosis. Indian J Med Res; 140(4):531-7.
  • Tak V, Mirdha BR, Yadav P, Vyas P, Makharia GK, Bhatnagar S. 2014. Molecular characterisation of Giardia intestinalis assemblages from human isolates at a tertiary care centre of India. Indian J Med Microbiol; 32(1):19-25.
  • Dwivedi S, Das BK, Aneja S, Sharma S, Chaturvedi MK, Kahn G, Fitzwater SP, Chandran A, Wadhwa N, Bhatnagar S. 2014. Group B Streptococcal Meningitis in Infants Beyond the Neonatal Period. Indian J Pediatr; 81(1):4-8.
  • Ramachandran P, Fitzwater SP, Aneja S, Verghese VP, Kumar V, Nedunchelian K, Wadhwa N, Veeraraghavan B, Kumar R, Meeran M, Kapil A, Jasmine S, Kumar A, Suresh S, Bhatnagar S, Thomas K, Awasthi S, Santosham M, Chandran A. 2013. Prospective multi-centre sentinel surveillance for Haemophilus influenzae type b & other bacterial meningitis in Indian children. Indian J Med Res; 137(4):712-20.
  • Bhat AS, Chaturvedi MK, Saini S, Bhatnagar S, Gupta N, Sapra S, Gupta SD, Kabra M. 2013. Prevalence of celiac disease in Indian children with Down syndrome and its clinical and laboratory predictors. Indian J Pediatr; 80(2):114-7.
  • Vohra P, Bhatnagar S. 2012. Childhood diarrhea. J Indian Med Assoc; 110(11):848-9.
  • Makharia GK, Verma AK, Amarchand R, Bhatnagar S, Das P, Goswami A, Bhatia V, Ahuja V, Datta Gupta S, Anand K. 2011. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol; 26:894-900. 
  • Gulani A, Bhatnagar S, Sachdev HP. 2011. Neonatal zinc supplementation for prevention of mortality and morbidity in breastfed low birth weight infants: systematic review of randomized controlled trials. Indian Pediatr; 48(2):111-7.
  • Yadav P, Das P, Mirdha BR, Gupta SD, Bhatnagar S, Pandey RM, Makharia GK. 2011. Current spectrum of malabsorption syndrome in adults in India. Indian J Gastroenterol; 30(1):22-8.
  • Bhatnagar S#, Alam S, Gupta P. (Editorial). 2010. Management of Acute Diarrhea: From Evidence to Policy. Indian Pediatr; 47:215-7.
  • Bhatnagar S#, Bhatia V, Wadhwa N, Kumar H. 2008. Low osmolarity ORS and Zinc supplementation in the management of acute watery diarrhea in children. Indian J Pediatr; 75(SS1)S53-6.
  • Bhatnagar S#, Wadhwa N, Bhatia V, Aggarwala A. 2008. Practical issues in dietary management of persistent diarrhea in developing countries. Indian J Pediatr; 75(SS1)S123-8.
  • Bhatnagar S#, Lodha R, Choudhury P, Sachdev HP, Shah N, Narayan S, Wadhwa N, Makhija P, Kunnekel K, Ugra D. 2007. Consensus statement of the IAP National Task Force: status report on management of acute diarrhea. Indian Pediatr; 44:380-9.
  • Bhatnagar S#, Lodha R, Choudhury P, Sachdev HP, Shah N, Narayan S, Wadhwa N, Makhija P, Kunnekel K, Ugra D.  2007. IAP guidelines 2006 on hospital based management of severely malnourished children. Indian Pediatr; 44:443-61.
  • Bhatnagar S#, Tandon N. 2006. Diagnosis of Celiac Disease. Indian J Pediatr; 73(8):703-9. 
  • Bhatnagar S, Bhandari N, Mouli UC, Bhan MK. 2004. IAP National Task Force. Consensus Statement of IAP National Task Force: status report on management of acute diarrhea. Indian Pediatr; 41(4):335-48.
  • Bhatnagar S#, Mouli Natchu UCM. 2004. Editorial: Coeliac disease in Indian children. Natl Med J India; 17:124-27. (Cited:03, I.F: 1.0)
  • Bhatnagar S#, Natchu Mouli UC. 2004. Zinc in child health and disease. Indian J Pediatr; 71:991-5.
  • Bhan MK, Bhatnagar S. 2004. Editorial: Racecadotril-Is there enough evidence to recommend it for treatment of acute diarrhea? Indian Pediatr; 41:1203-4.
  • Bhatnagar S#. 2000. Comment on “Is starch the answer for cholera?” Selected Summaries Nat Med J India; 13:252-3.
  • Bhatnagar S, Bhan MK.1999. Serological diagnosis of Coeliac Disease. Indian J Pediatr; 66:S26-S31.
  • Bhatnagar S, Bhan MK. 1997. Current antibiotic choice for enteric fever. Indian Pediatr; 34:173-174.
  • Bhan MK, Bhandari N,Bhatnagar S, Bahl R. 1996. Epidemiology and management of persistent diarrhoea in children of developing countries. Ind J Med Res;104:103-14.
  • Bhatnagar S,Singh KD. 1995. Management of Persistent Diarrhoea. JIMA; 93(6):227-30.
  • Bhatnagar S,Singh KD. 1995. Management of Dysentery. JIMA; 93(6):235-6.
  • Bhandari N, Bhan MK, Bhatnagar S. 1991. Fluid therapy in acute diarrhoea. Indian J Pediatr; 58:733-43.
  • Bhan MK &Bhatnagar S. 1991. Drug therapy in acute and persistent diarrhoea. Indian J Pediatr; 58:789-94.
  • Bhan MK, Sazawal S, Raj P, Bhandari N, Kumar R, Bhardwaj Y, Srivastava R, Bhatnagar S. 1989. Aggregative Escherichia coli, Salmonella, and Shigella are associated with increasing duration of diarrhoea. Indian J Pediatr; 56:81-6. 
  • Khoshoo V, Raj P Srivastava, Bhandari N, Sazawal S, Bhatnagar S, Bhan MK. 1989. Efficacy of nalidixic acid in the treatment  of acute bloody diarrhoea. Indian Pediatr; 26:1135-8.
  • Bhan MK, Khoshoo V, Bhatnagar S, Bhandari N, Ghai OP. 1988. Increased food intake in children treated with puffed rice based ORS. Indian Pediatr; 25:193-5.

Chapters in standard text books

  • Vohra P, Bhatnagar S. 2015. When to Suspect Celiac Disease in a Child?  Handbook of Celiac Disease: Pub: Kontentworx, a division of KWX Communications Pvt. Ltd.;37-41
  • Bhatnagar S, Dabas A, Shah D. 2015. Persistent Diarrhea. PG Textbok of Pediatrics, Volume 2. Pub: Jaypee Brothers Medical Publisher (P) Ltd.;1404-1408
  • Bhatnagar S, Vohra P,Kunnekal K. 2013. Antimicrobial therapy in acute gastroenteritis. Rational Antimicrobial Practice in Pediatrics. Eds: Shah N, Singhal T. Pub: Indian Academy of Pediatrics. 
  • Bhatnagar S,Singh M, Chaturvedi M. 2012.  Acute Gastroenteritis. Medical Emergencies in Children, 4th edition Pub: Sagar
  • Bhatnagar S, Rangan P, Chaturvedi MK. 2012. Oral rehydration therapy and zinc supplementation; Acute Diarrhea in Children, Pub: Elsevier, a division of Reed Elsevier India Private Limited,.
  • Bhatnagar S, Lodha R, Bhatia V, Wadhwa N, Agarwala A. 2009. Nutrition. Ghai Essential Pediatrics, 7th Edn. Pub: CBS & Distributors;57-77.
  • Bhatnagar S, Aggarwal A, Kumar P. 2007. Nutritional management of Celiac disease in Basics of Clinical Nutrition. Ed: Joshi YK;302-16. 
  • Bhatnagar S,Singh M. 2007. Medical Emergencies in Children, 4th edition Pub: Sagar;334-51. 
  • Bhatnagar S, Kunnekal K. 2006. Antimicrobial therapy in acute gastroenteritis. Rational Antimicrobial Practice in Pediatrics. Eds: Shah N, Singhal T. Pub: Indian Academy of Pediatrics;125-33.
  • Bhatnagar S, Aggarwal A, Sharma P. 2003. Nutritional management of Celiac disease in Basics of Clinical Nutrition. Ed: Joshi YK. Pub: Jaypee; 220-6.
  • Bhatnagar S, Bhatnagar V. 2003. Acute Abdomen in Principles of Pediatric Neonatal Emergencies Eds: Sachdev HPS, Choudhary P, Bagga A, Chugh K, Ramji S, Puri RK. Pub: Jaypee; 595-603.

Details of patents granted:

  • Bhatnagar S, Khanna N, Natchu UC, Wadhwa N, Gupta S, Bagga A, Saini S. “A method and device for detection of anti-transglutaminase antibodies”  (patent no. 1133/DEL/2011 dated 18-04-2011).
  • Monoclonal Antibodies specific to Salmonella typhi flagellin, and use thereof   Application number: 683/DEL/2015  Priority Date: 13th March, 2015
  • Production of recombinant Cytolethal Distending Toxin B protein and its uses as diagnostic tool thereof   Application number: 1350/DEL/2015  Priority Date: 14th May, 2015

Details of technology transferred/ developed:

  • Collaborated with International Center of Genetic Engineering and Biology, AIIMS and to develop easily available indigenous, rapid, sensitive and specific diagnostic tests for Celiac Disease.
  • Transferred the technology to JMitra in 2013 as per DBT guidelines
  • The ELISA and the rapid point of care tests were commercialized by the industry in October 2014 (Patent NO 1133/DEL/2011; dated 18.04.2011). JMitra & Co (industrial partner)

Summary of the key funded research programmes since 1985

Ongoing research support (at THSTI; Role: Principal Investigator)

  1. Creation of a bio repository and imaging data bank for accelerating evidence generation to facilitate children to thrive. A biobank of longitudinally collected varied bio specimens of women enrolled in the pregnancy cohort with well characterized information on environmental, clinical, social and epidemiological determinants at different time points will be established. Funding Agency/Grant (INR): Bill & Melinda Gates Foundation (BMGF) & United States Agency for International Development (USAID) with BIRAC, Department of Biotechnology, Government of India as part of the All Children Thriving Grand Challenges Program/3,25,00,000.
  2. Pediatrics Biology Program at THSTI:Mandate: Develop multidisciplinary research programs that bridge the gap between clinical and population epidemiology on one hand and mechanistic biology on the other with the ultimate mission of finding robust sustainable solutions for critical public health problems for neonates, infants and children. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/ 20,65,85,000
  3. Glue Grant Scheme-1: Multidiciplinary program to facilitate “bedside to bench and back to the bedside” research between research institutions (Translational Health Science and Technology Institute, National Brain Research Center, Regional Center for Biotechnology) and Gurgaon Civil Hospital as a model of ‘grassroots’ level implementable clinical research in hospitals outside of tertiary academic medical centers. A clinical research centre has been established at the district hospital as part of this collaboration and three large studies have been intiated; (i) Vitamin D supplementation to improve immune response to vaccines administered in early infancy- randomized placebo controlled study, (ii) Inter institutional program for Maternal, Neonatal and Infant Sciences, (iii) Social Innovation Immersion Programme Fellowship. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/ 5,73,06,000
  4. Pediatric Renal Biology Program Research on Nephrotic Syndrome. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/8,91,49,816
  5. Inter Institutional Program for Maternal, Neonatal and Infant Sciences-A translational approach to studying preterm birth. A large cohort of pregnant women has been initiated at Gurgaon Civil Hospitalin Haryana where 8000 woman will be followed from the first trimester of pregnancy till delivery and for 42d post partum. Primary objective is to elucidate causal biological and non-biological risks of preterm birth and its clinical consequences to create important knowledge-driven interventions and technologies that can be sustainably implemented in clinical practice and in the community.  Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/ 48,85,32,796
  6. Zinc as an adjunct for the treatment of very severe disease in infants younger than 2 months. Individually randomized double-blind placebo-controlled hospital-based multi (8) center, multi country (India, Nepal, Norway) study to evaluate the efficacy of daily administration of 10 mg of elemental zinc along with standard antibiotic therapy to infants aged 1 day up to 2 months hospitalized with clinical sepsis on case fatality. Mechanistic studies will be conceptualized and initiated within the RCT to understand sepsis biology and how zinc works in the context of sepsis.Funding Agency/Grant (INR):Reseacrh Council of Norway/21,08,35,990
  7. Glue-Grant scheme-2: Developing a long-term partnership for translational health research in child health between the Department of Pediatrics, AIIMS and the Pediatric Biology Center, THTSI. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/ 6,90,41,937 (with AIIMS)
  8. Development of a rapid diagnostic test for diagnosis of Celiac disease. Collaborative program between Translational Health Science and Technology Institute, International Center for Genetic Engineering & Biotechnology, All India Institute of Medical Sciences and an industry partner (patent no. 1133/DEL/2011 dated 18-04-2011). Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/96,87,356

Recently granted research support (At THSTI; Role: Co-Principal Investigator)

  1. Maternal micronutrient and genetic associations with pregnancy outcomes in North India.Funding Agency/Grant (GBP): Bill Melinda Gates Foundation/ $855,553
  2. Validation of a metabolite panel for postnatal assessment of gestational age on cord blood and neonate heel dried blood spot in low and middle-income resource settings in India. Funding Agency/ Grant (INR): Bill Melinda Gates Foundation/ 1,66,80,170
  3. Studies on placental regulatory mechanisms in abnormal pregnancies and exosome specific metabolomic signatures in adverse pregnancy outcomes. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/30,00,000
  4. Understanding the distinct development and functional properties of the neonatal immune system and their clinical consequences in the neonatal period. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/ 1,68,57,440
  5. HLA-G 5’URR genotyping in small for gestational age neonates compared to appropriate for gestational age neonates. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/4,00,00,00
  6. Stress outcomes on pregnancy, fetal growth and birth weight: Development of methods to identify mothers at risk of preterm birth and intrauterine growth restriction resulting from maternal stress. Funding Agency/Grant (INR): Bill & Melinda Gates Foundation (BMGF) & United States Agency for International Development (USAID) with BIRAC, Department of Biotechnology, Government of India as part of the All Children Thriving Grand Challenges Program/3,25,00,000

Completed research support (Role: Co- investigator)

At THSTI      

 

  1. Profiling of placental physiologic signature during pregnancy in maternal liquid biopsies. Funding Agency/Grant (INR):Bill & Melinda Gates Foundation/ 31,93,824
  2. The development of immersion based innovation program that target the neglected tail of health care innovation for maternal and child health in India. Funding Agency/Grant (INR): Biotechnology Industry Research Assistance Council/ 9,11,70,00
  3. Neonatal immune profiles: infections and toxicants.Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/88,08,576
  4. Social Innovation Immersion Programme Fellowship: The development of immersion based innovation program that targets the neglected tail of health care innovation for maternal and child health in India. Collaborative program between THSTI, Gurgaon General Hospital, Maulana Azad Medical College, All India Institute of Medical Sciences and Safdarjung Hospital, Kalawati Saran Children Hospital and an Industry partner; Coordinated by THSTI. Funding Agency/Grant (INR): Biotechnology Industry Research Assistance Council/91,17,000
  5. Molecular mechanisms of minimal change disease nephrotic syndrome: Role of CD80. Funding Agency/Grant (INR):  Department of Biotechnology, Govt. of India/4,70,9600
  6. Vitamin D Supplementation to improve immune response to vaccines administered in early infancy- randomized placebo controlled study. Funding Agency/Grant (INR): Department of Biotechnology, Govt. of India/1,60,00,000

At AIIMS

  • Role of gain in fat mass in early infancy on programming of adiposity and biochemical markers associated with cardiometabolic risk. Funding Agency: Department of Biotechnology, GOI
  • ICMR Advanced Center for Newborn Health and Research.Funding Agency: Indian Council of Medical Research
  • Development of a sensor platform - DXPhone that turns any camera phone into a glucose monitor. Funding Agency: Biotechnology Industry Research Assistance Council

 

Completed research support 

(Role: Principal Investigator)

  • Hib Meningitis Sentinel Surveillance in North India.Collaborative program between Translational Health Science and Technology Institute, All India Institute of Medical Sciences and Kalawati Saran Children’s Hospital; Coordinated by THSTI. Funding Agency: INCLEN
  • Cross sectional study of cord blood immune markers in term appropriate for gestational age and small for gestational age neonates. Funding Agency: THSTI
  • Etiology and characteristics of influenza and other pathogens in acute lower respiratory infection in severe and very severe pneumonia in hospitalized children 2-24 months of age. Funding Agency: Johns Hopkins Bloomberg School of Public Health, USA
  • Efficacy of zinc in the treatment of severe and very severe pneumonia in hospitalized children 2-24 months of age. Funded by Johns Hopkins Bloomberg School of Public Health, USA and World Health Organization.
  • Zinc as an immunomodulator in the treatment of possible serious bacterial infections in infants more than 7 days and up to 4 months of age. Funding Agency: Department of Biotechnology, Govt. of India and the European Union
  • Effects of administering 10 mg of zinc orally to young infants aged 7 days and up to 4 months with possible serious bacterial infection on survival and function of peripheral blood mononuclear cells. Funding Agency: Department of Biotechnology, Govt. of India and the European Union.
  • Intravenous autologous bone marrow-derived stem cell therapy of patients with acute ischemic stroke; A multi-institutional project. Funding Agency: Department of Biotechnology, Govt. of India
  • Data Management of the multicenter trial on the efficacy of stem cell in improvement of LVF in patients with Acute Myocardial Infarction. Funding Agency: Department of Biotechnology, Govt. of India
  • Specific targeted research or innovation project. Funding Agency: European Union
  • Etiological significance of microscopic colitis in chronic diarrhea in children and its pathogenesis. Funding Agency: Indian Council of Medical Research
  • Extended studies on safety and efficacy of zinc-ORS compared to ORS alone in hospitalized children with severe and complicated acute diarrhea. Funding Agency: Indo-Norwegian Programme of Institutional Cooperation
  • Helicobacter pylori infection in early childhood: characterization of isolates and determination of their ability to exert pathogenic effect in in-vitro and in-vivo models. Funding Agency: Indian Council of Medical Research
  • Evaluation of zinc supplementation as adjunct to ORT in acute non-cholera diarrhea. Funding Agency: World Health Organization
  • Randomized controlled trial of low glucose ORS formulation and standard WHO glucose electrolyte solution in the treatment of acute diarrheal dehydration. Funding Agency: World Health Organization

Role: Co-Principal Investigator/Co-Investigator)

  • Immunological effect of zinc supplementation in HIV infected children receiving highly active antiretroviral therapy.  Funding agency: Indian Council of Medical Research
  • Zinc supplementation in childhood tuberculosis patients in Delhi, India. Funded by University of Bergen, Norway
  • Randomized controlled trial of low glucose ORS formulation and standard WHO glucose electrolyte solution in the treatment of acute diarrheal dehydration. Funding Agency: World Health Organization
  • Development of a dietary algorithm for children aged 3-36 months with persistent diarrhea. Funding Agency: World Health Organization
  • Efficacy of feeding yoghurt in comparison to milk to malnourished children with acute diarrhea. Funding Agency: World Health Organization
  • Randomized controlled trials of new ORS formulations (glycine, glutamine, alanine) and WHO glucose electrolyte solution in the treatment of acute diarrheal dehydration. Funding Agency: World Health Organization
  • Efficacy of oral gentamicin therapy in persistent diarrhea in hospitalized children aged 4-36 months. Funding Agency: World Health Organization

 

  • Fellow Indian National Science Academy, 2017
  • Fellow National Academy of Medical Sciences, 2016
  • Fellow National Academy of Sciences, 2007
  • Shri. Har Bhagwan Kumar Oration, Indian Academy of Pediatrics, 2012  
  • Member National Academy of Sciences
  • Member National Academy of Medical Sciences
  • WHO Temporary Advisor for research in childhood diarrheal diseases
  • Recognition for research in Pediatric Gastroenterology at 2nd World Congress of Pediatric Gastroenterology, Hepatology & Nutrition, 2004
  • Hotam Tomar Gold Medal in recognition of excellent scientific contribution and services in Paediatric Gastroenterology and Nutrition,1995
  • Dr. ST Achar Gold Medal Award for Research in Child Health, 1989

Contribution in International and National Technical and Scientific Expert Groups (in Addition to those Referred to in the Section on Contribution to Global and National Policy)

Wellcome Trust/DBT India Alliance             

  • Member of the Review Committee for the Fellowship program on clinical and public health research
  • Member of the Review Committeefor the Research training fellowship for clinicians

Bill & Melinda Gates Foundation

  • Faculty on the program for Accelerating research and development to address the global crisis of preterm birth
  • Faculty on the program on Development of new strategies to improve zinc status in children with environmental enteropathy at risk of diarrhea

Biotechnology Industry Research Assistance Council

  • Member Task Force BIRAC-Biotechnology Ignition Grant
  • Member Expert Group for the program on Achieving Health Growth Through Agriculture and Nutrition; Innovations and Interventions Targeting Growth and Development (joint program between BIRAC - Bill & Melinda Gates Foundation)

 

 

Ministry of Health and Family Welfare, Government of India:

  • National Convener,IAP Plan of Action, Current Evidence-Based Management of Diarrhea, IAP and UNICEF Project on Diarrhea
  • Core Group Member for developing training modules on Facility Based Care of Severe Acute Malnutrition for Ministry of Health & Family Welfare and WHO India
  • Member Technical Consultation on Strategies For Prevention and Control of Iron Deficiency Anemia Amongst Under Three Children, Sponsored by: MOST India: The USAID Micronutrient Program.
  • Member National Consultation to Review Existing Guidelines in ICDS Scheme inthe Field of Health and Nutrition, New Delhi
  • Member Task Force, National Consultation on Benefits and Safety of Administration of Vitamin A to Pre-School Children and Pregnant and Lactating Women

Department of Biotechnology, Government of India

  • Expert Member Technical Screening Committee of Small Business Innovation Research Initiative
  • Member Research Advisory Committee ofPostgraduate Medical Institute, Chandigarh
  • Member of the Expert Group Indo - US Low Cost Diagnostics and Therapeutics in Medicine
  • Member Task Force for identifying Centers for Food and Nutritional Sciences Research
  • Member Expert cum Monitoring Group for Clinical Trials on Curcumin in Cancer
  • Member Expert Group of the Biotechnology Industrial Partnership Program
  • Member Task Force for identifying Priority Research Areas in Probiotics in Health
  • Member Expert Group for the DBT-DST-Agency for Science Technology & Research, Singapore Joint Program on Advances in Chemistry, Biology and Technology for Medicine
  • Member Human Studies Committee

Indian Council of Medical Research

  • Review Committee for identifying Research Proposals for the Indo-US Collaborative Programs
  • Member Expert Group on Probiotics
  • Member Expert Group for identifying Research Priorities in Celiac Diseases in India          

Advisor/Member for other International Organizations

  • Member Steering Committee MIT-DBT Program on Promoting Translational Research in India
  • Member of Technical Advisory Board for Diarrhea, Institute of One World Health
  • Working Group of Celiac Disease, Commonwealth Association of Pediatric Gastroenterology, Hepatology and Nutrition

Others:

  • Member Governing Body, Rajdhani College, Delhi University

 


DR. SHAILAJA SOPORY
SCIENTIST D

DR. NIRAJ KUMAR
RESEARCH SCIENTIST C

DR. SUSMITA CHAUDHURI
RESEARCH SCIENTIST C

DR. GAURAV BATRA
ASSISTANT PROFESSOR

DR. SAVIT B. PRABHU
SCIENTIST C

DR. UMA CHANDRA MOULI NATCHU
ASSOCIATE PROFESSOR

DR. MONIKA BAHL
DIRECTOR CPM

DR. PALLAVI KSHETRAPAL
RAMALINGASWAMY FELLOW

DR. RAMACHANDRAN T.
PH.D STUDENT

DR. NITYA WADHWA
ASSISTANT PROFESSOR