People : Scientific : Faculty & Scientists

DR. SHAILAJA SOPORY, Ph.D. 

Scientist D
+91-129-2876345  (+91-129-2876345)
ssopory [at] thsti [dot] res [dot] in
Ph.D, Indian Institute of Science, Bangalore, KA
M.S. Biological Sciences, Indian Institute of Science, Bangalore, KA
B.Sc.(H) Biochemistry, Daulat Ram College, Delhi University

Present Research Interest

My laboratory works in collaboration with the laboratory of Dr. Uma Chandra Mouli Natchu. We are interested in looking at the development of the neonatal immune system at the immunophenotypic and functional level. We are trying to understand the role of nutrition, intestinal inflammation and microbial exposures to linear growth in children during the initial stages of their life.

Another aspect of the research involves looking at specific childhood diseases, like minimal change nephrotic syndrome in children, which is associated with proteinuria (loss of protein in the urine) due to disruption of the podocyte slit diaphragm (a modified tight junction specific to the podocyte). This forms part of a larger picture of finally looking at loss of barrier function in other epithelial cells during infection and inflammation.

1) Neugebauer JM, Kwon S, Kim HS, Donley N, Tilak A, Sopory S, Christian JL. The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo.Proc Natl Acad Sci U S A. 2015 Apr 20. pii: 201501449. [Epub ahead of print]

2) Rathore DK, Nair D, Raza S, Saini S, Singh R, Kumar A, Tripathi R, Ramji S, Batra A, Aggarwal KC, Chellani HK, Arya S, Bhatla N, Paul VK, Aggarwal R, Agarwal N, Mehta U, Sopory S, Natchu UC, Bhatnagar S, Bal V, Rath S, Wadhwa N. Underweight full-term Indian neonates show differences in umbilical cord blood leukocyte phenotype: a cross-sectional study. PLoS One. 2015 Apr 21;10(4):e0123589. doi: 10.1371/journal.pone.0123589. eCollection 2015.

3) Sinha A, Bajpai J, Saini S, Bhatia D, Gupta A, Puraswani M, Dinda AK, Agarwal SK, Sopory S, Pandey RM, Hari P, Bagga A. Serum-soluble urokinase receptor levels do not distinguish focal segmental glomerulosclerosis from other causes of nephrotic syndrome in children. Kidney Int. 2014 Mar;85(3):649-58. doi: 10.1038/ki.2013.546. Epub 2014 Jan 15.

4) Sopory, S., Kwon, S., Wehrli, M., Christian, J.L. Regulation of Decapentaplegic activity and signaling range by tissue-specific cleavage of an upstream site within the prodomain. Developmental Biology (2010) 346: 102-112.

5) Biswas, KH, Sopory, S, Visweswariah, SV. The GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP. Biochemistry. 2008 Mar 18;47(11):3534-43.

6) Goldman, D.D., Hackenmiller, R., Nakayama, T., Sopory, S. Wong, C. Kulessa, H.Christian, J.L., Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development (2006) 133(10):1933-42.

7) Sopory, S., Nelsen, S.M., Degnin, C.R., Wong, C.R., Christian, J.L.Regulation of Bone Morphogenetic Protein-4 Activity by Sequence Elements within the Prodomain. Journal of Biological Chemistry (2006) 281(45):34021-31.

8) Sopory, S., Kaur, T. and Visweswariah, S.S. The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion. Cellular Signaling (2004) 16 (6):681-692.

9) Sopory, S., Balaji, S., Srinivasan, N. and Visweswariah, S.S. Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5. FEBS Letters (2003) 539 (1-2) 161-166.

10)Bakre, M. M., Sopory, S. and Visweswariah, S. S. Expression and Regulation of the cGMP-binding, cGMP-specific Phosphodiesterase (PDE5) in human colonic epithelial cells: Role in the induction of cellular refractoriness to the heat-stable enterotoxin peptide. Journal of Cellular Biochemistry (2000) 77: 159-167.