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Scientist C
savit [at] thsti [dot] res [dot] in
M.B.B.S. - Government Medical College Calicut, Calicut University, Kerala, India
M.D. (Pathology) - All India Institute of Medical Sciences (AIIMS), New Delhi, India
Post-doctoral research - National Institute of Immunology, New Delhi, India

Present Research Interests

The focus of my ongoing research is to study physiological mechanisms in the foetus and neonate that are of relevance to understanding the pathophysiology of adverse outcomes in intra-uterine and neonatal period. I work in close collaboration with Uma Chandra Mouli Natchu, Shailaja Sopori, Nitya Wadhwa, Pallavi Kshetrapal and Shinjini Bhatnagar (Paediaric Biology Centre, THSTI) and under the mentorship of Satyajit Rath, Vineeta Bal and Anna George (NII). Using cellular and flow-cytometry based Immunologic approaches in mouse models and humans, I work on :

  • Understanding the relative contributions of genetic and environmental factors shaping the normal immune phenotype and function in humans
  • Functional and developmental maturation of the neonatal immune system with the aim to understand immune mechanisms contributing to neonatal infectious morbidity.
  • Immune mechanisms contributing to fetal tolerance during pregnancy
  • Prabhu SB, Rathore DK, Nair D, Chaudhary A, Raza S, Kanodia P, et al. Comparison of Human Neonatal and Adult Blood Leukocyte Subset Composition Phenotypes. PloS One. 2016;11(9):e0162242.
  • Rane S, Das R, Ranganathan V, Prabhu S, Das A, Mattoo H, et al. Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function. BMC Biol. 2014;12:106.
  • Prabhu SB, Khalsa JK, Banerjee H, Das A, Srivastava S, Mattoo HR, et al. Role of apoptosis-inducing factor (Aif) in the T cell lineage. Indian J Med Res. 2013 Nov;138(5):577–90.
  • Salam N, Rane S, Das R, Faulkner M, Gund R, Kandpal U, Lewis V, Mattoo H, Prabhu SB, Ranganathan V, Durdik J, George A, Rath S, Bal V. T cell ageing: effects of age on development, survival & function. Indian J Med Res. 2013 Nov;138(5):595–608.
  • Gupta P, Jagya N, Prabhu SB, Durgapal H, Acharya SK, Panda SK. Immunohistochemistry for the diagnosis of hepatitis E virus infection. J Viral Hepat. 2012 Feb;19(2):e177-183.
  • Prabhu SB, Gupta P, Durgapal H, Rath S, Gupta SD, Acharya SK, et al. Study of cellular immune response against Hepatitis E virus (HEV). J Viral Hepat. 2011 Aug;18(8):587–94.