People : Scientific : Faculty & Scientists

DR. SAMEENA KHAN, PhD 

Inspire Faculty
+91-129-2876498 
sameena [at] thsti [dot] res [dot] in
Postdoctoral Training - International Centre for Genetic and Engineering and Biotechnology (ICGEB), New Delhi
Ph.D. in Structural Biology - International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi
Master in Biotechnology-Banasthali Vidyapith, Rajasthan

My group is interested in decrypting the fine balance between ubiquitination and deubiquitinationprocesses, and probe how this fine-tuning regulates metabolic disorders such as diabetes and cardiovascular diseases. Currently we are focusing on the biochemical-biophysical and cellular investigations of E3 ligases and DUBs components of the vast ubiquitin proteasome machinery and interested in looking how this machinery affects the cellular processes. We are mainly focused on the regulatory aspects of selected proteins from E3 ligases and DUBs family, with diverse functionalities. We are also interested to see the ubiquinylated proteins in the cardiomyocytes and to link it with the E3 ligases and DUBs.

Additionally, my group is part of target validation group at DDRC. The aim here to support the drug discovery research programmes, which includes the identification and characterization of new targets for drug discovery. 

  • Khan S*: Recent advances in our understanding of the biology and drug targeting of malaria parasite aminoacyl-tRNAsynthetases. Malaria Journal, 2016 (* first and the corresponding author).
  • Khan S, Sharma A, BelrhaliH, YogavelM & Sharma A: Structural basis of malaria parasite lysyl-tRNAsynthetase inhibition by cladosporin. J StructFunctGenomics, 2014
  • Manhas R, TripathiP, Khan S, SethuLakshmiB, LalSK, GowriVS, SharmaA, MadhubalaR. Identificationandfunctionalcharacterizationofa novel bacterialtypeasparaginesynthetase A: atRNAsynthetase paralogfromLeishmaniadonovani. J BiolChem. 2014
  • Khan S, GargA, SharmaS,Camacho N, PicchioniD, Saint-LégerA, Ribas de PouplanaL, YogavelM & SharmaA: Anappendeddomainresultsin anunusualarchitecturefor malariaparasite tryptophanyl-tRNAsynthetase. PlosOne. 2013
  • Khan S, GargA, Camacho N, Van RooyenJ, Pole AK, BelrhaliH, Ribas de PouplanaL, SharmaV & SharmaA: Structuralanalysisofmalariaparasite lysyl-tRNAsynthetase providesplatformfor drugdevelopment. ActaCrystallogrD BiolCrystallogr. 2013
  • Bhatt TK,*Khan S,*DwivediVP, BandayMM, Sharma A, ChandeleA, Camacho N, Ribasde PouplanaL, Wu Y, Craig AG, MikkonenAT, Maier AG, YogavelM & Sharma A: Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses. Nature Communications, 2011 (* these authors have contributed equally)
  • Khan S*, Sharma A*, JamwalA*, Sharma V, Pole AK, Thakur KK & Sharma A: Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum. Scientific Reports, 2011 (* these authors have contributed equally).
  • Jackson KE*, HabibS*, FrugierM, HoenR, Khan S,Pham JS, Ribasde PouplanaL, RoyoM, Santos MA, Sharma A & Ralph SA: Protein translation in Plasmodium parasites. Trends Parasitol. 2011.Review
  • YogavelM, Khan S, Bhatt TK & Sharma A: Structure of D-tyrosyl-tRNATyrdeacylaseusing home-source Cu Kalphaand moderate-quality iodide-SAD data: structural polymorphism and HEPES-bound enzyme.ActaCrystallogrD BiolCrystallogr. 2010.
  • Bhatt TK, KapilC, Khan S, JairajpuriMA, Sharma V, SantoniD, SilvestriniF, PizziE & Sharma A:  A genomic glimpse of aminoacyl-tRNAsynthetasesin malaria parasite Plasmodium falciparum. BMC Genomics2009
 
  • “Deciphering the role of human protein degradation machinery in metabolic syndrome”. (Granted By DST) for 5 years (2014-2019) as Principal Investigator
  • “Molecular dissection of the functioning of ubiquitin proteasome modules; Mulanand USP18 and their implications in metabolic disorder”. (Granted by INSA) for 3 years (2016-2019) as Principal Investigator
  • NASI Young Scientist Platinum Jubilee Award, 2016
  • Associate of the Indian Academy of Sciences, 2016
  • INSA Medal for Young Scientist Award, 2015
  • INSPIRE faculty fellowship, 2014
  • BiocareDBT Young scientist fellowship, 2014
  • Best Poster Award at International Symposium-cum-workshop New Advances in X-Ray Diffraction and Cryo-Electron Microscopy, 2014
  • Global travel Award Winner (Bill and Melinda Gates foundation)- Keystone, Malaria, 2013
  • Abstract selected for XXIV tRNAconference, 2012
  • Qualified CSIR-UGC SRF Fellowship (June, 2011)
  • Merit Scholarship holder during M.Sc(Biotechnology) 


MS. KANIKA SINGH
SENIOR RESEARCH FELLOW

DR. SUDHA
RESEARCH ASSOCIATE

MR. HEM CHANDRA JOSHI
LAB TECHNICIAN

MR. ASHISH SARKAR
LAB TECHNICIAN

MR. VIKAS DHAR DUBEY
TECHNICAL ASSISTANT ( GLOBAL METABOLOMICS )