People : Scientific : Faculty & Scientists

DR. PRABHANSHU TRIPATHI, Ph.D. 

Ramalingaswamy Fellow
+91-129-2876474 
prabhanshu [at] thsti [dot] res [dot] in
Ph.D. from CSIR-Institute of Genomics and Integrative Biology, Delhi
M.Sc. in Biotechnology from University of Allahabad, Uttar Pradesh

 

Research  Interests

  • Inflammation & Immunology– Mechanisms involved in immune regulation and autoimmunity.
  • To explore the role of microbiome in human health.

 

Research  Experiences

  • Post doctoral Fellow, Jan.2013-Dec. 2015

                  Department of Microbiology and Immunology,

                  University of Gothenburg, Gothenburg,  Sweden

 

  • Post doctoral Fellow, April 2011- Dec. 2012

             Department of Pathology, University of Chicago Medical Centre,

             Chicago, Illinois, USA

 

  • Visiting Faculty, May 2010 - March. 2011

             School of Public Health, Johns Hopkins University,

               Baltimore, Maryland, USA

  • Tripathi P,  Sedimbi S, Karlsson M, Yrlid U,  Kadri N and  Cardell S.TLR stimulation of type II NKT cells requires cell to cell contact with DCs with involvement of CD40-CD40L and IL-12p40.J Immunol 2015 194:192.20
  • Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy KD, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos D, Zhou L, Chang EB, Fu YX, and Nagler CR.  Commensal bacteria-induced regulatory T cells protect against systemic allergic responses to food. Proceedings of the National Academy of Sciences: 2014; 111(36): 13145-50
  • Tripathi P, Nair S,  Singh  BP,  Arora  N. Supplementation of Antioxidants Glutathione and Alpha Lipoic Acid Attenuates Oxidative Stress and Th2 Response in Allergic Airway Inflammation. Indian journal of allergy, asthma and immunology: 2013; 27(1): 19-26
  • Feehley T, Stefka A, Tripathi P, McCoy K, Mazmanian S, Seo GY, Theriault B,  Antonopoulos D, Chang E, and Nagler C. Commensal bacteria induce a barrier protective response to prevent sensitization to food allergens. J Immunol: 2013; 190:120.19
  • Tripathi P, Stefka A, FeehleyT, Patton T,Chang E, Antonopoulos D, Pei Z and Nagler C. Antibiotic induced alterations in the commensal microbiome reduce CD4+Foxp3+Tregs in the colonic lamina propria and increase allergic responses to food. J Immunol :2012;188:175.14
  • Tripathi P, Stefka A, Feehley T,Pei Z and Nagler C.Tlr4-/- mice have reduced proportions of CD4+Foxp3+Tregs in the colonic lamina propria and increased susceptibility toallergic responses  to  food. J Immunol :2012;188:175.20
  • Feehley T,  Stefka A,  Tripathi P, Antonopoulos D, Chang E,  Theriault B,  and  Nagler C. Commensal bacteria regulate Treg abundance in a gnotobiotic model of food allergy. J Immunol :2012;188:120.
  • Tripathi P,Nair S, Singh BP, Arora N. Molecular and immunological characterization of subtilisin like serine protease, a major allergen of Curvularia lunataImmunobiology:2011; 216(3):402-8.
  • Tripathi P, Nair S, Singh BP, Arora  N.  Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation. Free Radic Biol Med: 2010;48(6):839-44.
  • Nair S.,Tripathi P.,Singh B.P., and Arora N. Glutathione with mutated glutathione-S-transferase shows synergistic effect in reducing oxidative stress and airway inflammation. Allergy :2010;65 (Suppl. 92): 90.
  • Arora N., Tripathi P., Nair S. and Singh B.P.  Molecular cloning and characterization of subtilisin like serine protease allergen from Curvularial unata.Allergy:2010;65 (Suppl. 92);183.
  • Tripathi P, Kukreja N,Singh BP, Arora N. Serine protease activity of Cur l 1 from Curvularia lunata augments Th2 response in mice. J Clin Immunol:2009;29(3):292-302.
  • Tripathi P., Singh B.P., and Arora N. Mutated Glutathione-S-Transferase Reduced Airway Inflammation In Murine Model. J of Allergy and Clin Immunol: 2008;117 (Suppl. 2):S186.
  • Tripathi   P,   Singh   BP,  Arora   N.   Mutated   Glutathione-s-transferase reduced   airway inflammation by limitingo xidative stress and Th2 response. Free Radic Biol Med: 2008; 45:1413-1419.
  • Tripathi P.,Singh B.P.,and Arora N. Bioinformatic analysis of Glutathione-s-transferase from   Curvularia  lunata  and  Epicoccum  purpurascens. Indian journal of allergy, asthma and immunology: 2006;20(2):125.
  • Tripathi P,Singh BP,Arora N.Recombinant allergens–gateway to efficient diagnosis and therapy for atopic asthma and rhinitis. Indian journal of allergy, asthma and immunology: 2006;20 (1):41-51.
  • Tripathi P and Sharma S. Immunology and Immunotechnology. In Singh R & Trivedi M (Eds.), Biotechnology: Trends and Applications(pp. 1-25). Studium Press LLC, Houston, TX , USA
  • Tripathi P, Singh BP,  Arora N,  A  formulation  useful for ameliorating  oxidative stress and airway inflammation. Indian patent filed (Application no.-1903/DEL/2009).

 

Title: Effect of environmental factors including diet and artificial sweeteners on gut microbiome and their consequences on type 2 diabetes

Duration: 2016-2020

Funding Agency:Department of Biotechnology (Govt. of India)

  • Awarded with Ramalingaswami re-entry fellowship from Dept. of Biotechnology (Govt. of India), India in 2015-16
  • Selectedf or‘Travel Award ’for oral presentation in annual meeting (May 4th to 8th, 2012) of ‘American Association of Immunology ’Boston, USA. Selected for Fellow in Training International Scholarship to attend ‘2008 Annual meeting of  American Academy of Allergy Asthma and Immunology (AAAAI)’ at Philadelphia, Pennsylvania, U.S.A (14th-18th March 2008).
  • Selected for International Travel Scholarship from European Academy of Allergy Asthma and   Immunology   to   attend   GA2LEN/EAACI   Allergy   School   in   Bischenberg   – Bischoffsheim   (near  Strasbourg),  France,  21st-24th  September  2007  on  the  topic “Recombinant Allergens: From Fundamental Aspects To Clinical Applications”.
  • UCB-ICAAI Young Scientist Award by Indian College of Allergy, Asthma and Applied Immunology in Dec 2006.
  • Member of Editoruial Board in *Reproductive Immunology* from Insight Medical Publishing, USA.
  • Trainee Member of American Association of Immunologists, BETHESDA, USA.
  • Fellow In Training Member of American Academy of Allergy Asthma and Immunology, MILWAUKEE, USA.
  • Fellow In Training Member of American College of Allergy Asthma and Immunology, ILLINOIS, USA.
  • Junior Affiliate Member of European Academy of Allergology and Clinical Immunology, STOCKHOLM, SWEDEN.
  • Qualified GATE (Graduate Aptitude Test in Engineering) in 2003.
  • Qualified CSIR-JRF in 2003
  • Qualified all India entrance for masters in Biotechnology, organised by Jawaharlal Nehru University, Delhi
  • Merit scholarship during graduation.

MS. MANISHA TYAGI
JUNIOR RESEARCH FELLOW