People : Scientific : Faculty & Scientists

DR. PALLAVI KSHETRAPAL, Ph.D. 

Ramalingaswamy Fellow
+91-129-2876353  (1292876613)
pallavi.kshetrapal [at] thsti [dot] res [dot] in
Post Doctorate from Harvard Medical School (HMS), Boston, USA
Ph.D. from Center for Cellular and Molecular Biology (CCMB), Hyderabad
M.Sc degree from Dept of Genetics, South campus, Delhi University

Present Research Interest

The broad focus of my research is to study pediatric health from a translational point of view. One of the major health challenges in child health is rising instances of pediatric cancers. One of my research goals is to study the underlying mechanisms that could lead to Pediatric cancers, especially the role of Notch synergies in T-cell Lymphoblastic Leukemias (T-ALLs). As a second aim, I am interested in studying the genetic factors that contribute to fetal tolerance during pregnancy, changes in which could lead to adverse pregnancy outcomes. Using molecular and cell biology techniques I would like to unravel the complex role of the genes that support normal fetal development. A thoughtful approach of mutually studying the genetic and hormonal factors, especially in the perinatal period will help us recognize the underlying mechanistic pathways that when modulated by environmental factors may lead to adverse pregnancy outcomes.

Awards and prize(s) won

  • Selected for the “Innovative Young Biotechnologist Award for the year 2013” by Department of Biotechnology.
  • Selected for the Ramalingaswamy Re-entry Fellowship of Department of Biotechnology (DBT) for the year 2012-2013.
  • Awarded the Prof. LSS Kumar award by the Indian National Science Academy for the year 2005.
  • Awarded the INSA young Scientist Medal by the Indian National Science Academy for the year 2005.
  • Awarded the Development Traveling Fellowship to visit Dr Matthew Freeman’s lab at the Medical Research Council (MRC), Cambridge (March- April 2004).
  • Visited Dr.Stephane Noselli’s Lab at Faculty de Sciences, Nice, France on an INDO-FRENCH exchange program (Jan-Feb 2004).
  • Awarded Delhi University, South Campus Endowment Scholarship. (1997-98).
  • Awarded ShantiPrasad Puraskar from Delhi University for outstanding performance in B.Sc Botany (Hons.) (1994-97).
  • Awarded a Science Meritorious Scholarship for securing first position in the college. (1994-97).

Research Articles

  • Pallavi S. K, Diana M. Ho, Chindo Hicks, Lucio Miele, Spyros Artavanis Tsakonas. (2012) Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. (EMBO; published online).
  • Silvia Fre, Pallavi S.K, Mathilde Huyghe, Marick Lae, Sylvie Robine, Spyros Artavanis-Tsakonas and Daniel Louvard. (2009). Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the mouse intestine.Proc Natl Acad Sci U S A. 6309–6314.
  • Pallavi S K, Kannan R, Shashidhara LS. (2006). Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev Biol. 296 (2):340-352.
  • Pallavi, S.K. and Shashidhara, L.S. (2005). Signaling capabilities of peripodial cells of the Drosophila wing imaginal disc. J Cell Sci. 118: 3363-3370.
  • Berger C., Pallavi S. K., Prasad M., Shashidhara L. S. and Technau G. M. (2005). A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nature Cell Biology 7, 56-62.
  • Bharathi V., Pallavi S. K., Bajpai R., Emerald B. S., and Shashidhara L.S. (2004). Genetic characterization of the Drosophila homologue of coronin. J Cell Sci. 117, 1911-1922.
  • Pallavi S. K. and Shashidhara L. S. (2003). EGFR/Ras mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130, 4931-1441.

 

Reviews

  • Berger C., Pallavi S. K., Prasad M., Shashidhara, L. S. and Technau, G. M. (2005). Cyclin E Acts under the Control of Hox-Genes as a Cell Fate Determinant in the Developing Central Nervous System. Cell Cycle. Mar 4; 4(3).