People : Scientific : Faculty & Scientists


Thsti National Chair, Head-ddrc
+91-129-2876448  (+91-129-2876448)
kanury [at] thsti [dot] res [dot] in
Pune University, Department of Chemistry, Pune, India, MSc, 1979
MS University, Department of Chemistry, India, PhD, 1983

Teaching Activity

Tutoring activities in the ICGEB Ph.D. Programme.


Scientific Activity

Our long-term interest is in understanding the regulatory parameters that influence the outcome of an immune response. Within this our current focus is to understand the mechanisms controlling plasticity in receptor-initiated signaling pathways. The experimental strategy involves a ‘systems level’ analysis of the antigen receptor-dependent signal transduction network. We measure the kinetic and quantitative contributions of various intermediates in the signaling pathways and then monitor how these contributions are modulated in response to specific perturbations within the network. Our larger goal is to delineate the overall structure of this network and also to characterize its dynamic features. We are particularly interested in deriving both quantitative and qualitative measures of signal output under conditions where the receptor is differentially activated. The aim here is to eventually understand how such information processing impacts on the gene expression profile.

Selected publications

  • Sharma, M., George, A.A., Singh, B.N., Sahoo,N.C., Rao, K.V.S. 2007. Regulation of TranscriptElongation through Cooperativeand Ordered Recruitment of Cofactors. J. Biol. Chem. 282, 20887-20896
  • Basu, S.K., Kumar, D., Singh, D.K., Ganguly, N.,Siddiqui, Z., Rao, K.V.S., and Sharma, Pawan. 2006. Mycobacterium tuberculosis secreted antigen(MTSA-10) modulates macrophagefunction byredoxregulation ofphosphatases. FEBSJ. 273, 5517-5534
  • George,A.A. Sharma, M., Singh, B.N., Sahoo,N.C., Rao, K.V.S. 2006. Transcription from a TATA andINR-less promoter: Spatial segregation of promoterfunction. EMBO J. 25, 811-821
  • Sethi, D.K., Agarwal, A,Manivel, V., Rao, K.V.S., Salunke, D.M. 2006. Differential epitope positioningwithin the germlineantibodyparatopeenhances promiscuityinthe primary immune response.Immunity24, 429-438
  • Sinha A, A Singh, V Satchidanandamand K Natarajan. 2006.Impairedgeneration ofreactive oxygen species duringdifferentiation of Dendriticcells (DCs) byMycobacterium tuberculosis secretoryantigen (MTSA) and subsequent activation ofMTSA-DCs by mycobacteriaresults in increased intracellularsurvival. JImmunol. 177, 468-478
  • Latchumanan, V.,Balkhi, M.Y., Sinha, A., Singh,B., Sharma, P., Natarajan, K. 2005. Regulation of immune responses to Mycobacterium tuberculosis secretoryantigens by Dendriticcells. Tuberculosis85, 377-383
  • Singh, D.K., Kumar, D.,Siddiqui, Z., Basu, S.K.,Kumar, V., Rao, K.V.S.2005. Thestrength ofreceptor signalingis centrallycontrolled through acooperativeloop between Ca2+and an oxidant signal. Cell121, 281-293
  • Chaturvedi, A., Siddiqui, Z.,Bayiroglu,F., Rao,K.V.S. 2002. A GPI-linked isoform of the IgDreceptor regulates restingB cellactivation. NatureImmunol. 3, 951-957
  • Manivel, V., Bayiroglu, F., Siddiqui, Z., Salunke,D.M., Rao, K.V.S. 2002. Theprimary antibodyrepertoirerepresents a linked networkofdegenerate antigen specificities. J. Immunol. 169, 888-897
  • Natarajan, K., Sahoo, N.C., Rao, K.V.S. 2001. Signal thresholds and modular synergyduring expression ofcostimulatorymolecules in Blymphocytes. J.Immunol. 167, 114-122
  • Manivel, V., Sahoo, N.C., Salunke, D.M., Rao, K.V.S. 2000. Maturation ofaprimary antibodyresponse isgoverned bymodulations in flexibilityof theantigen-combiningsite. Immunity13, 611-620