People : Scientific : Faculty & Scientists

DR. HUMA QURESHI, Ph D 

Senior Scientist
+91-129-2876332  (+91-129-2876332)
huma.qureshi [at] thsti [dot] res [dot] in
2002–2007: PhD Microbiology (HIV/AIDS vaccines development), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
2007–2011: Postdoc fellow, Center of comparative medicine and California National Primate Research Center, UCDavis, CA, USA.
2012: Postdoc fellow, The Gavin Herbert Eye institute, School of Medicine UC Irvine, CA, USA.

My current research focus is to isolate of broadly neutralizing antibodies from clinical samples of HIV-1 subtype C infected elite neutralizers using antigen specific single cell sorting strategy. Briefly, we extract RNA from a single cell and amplify heavy and light chains variable segments and clone them into antibody expression vectors. Thereafter, we express these antibodies into mammalian system and check their neutralization efficacy using TZMbl assay. HIV-1 subtype C causes more than 50% infections globally and it is very important to understand this particular subtype for developing vaccine and therapy against HIV-1.  HIV-1 subtype C specific broadly neutralizing antibodies is likely to give us information about the novel neutralizing epitopes targeted during HIV-1 subtype C infection.  Understanding of the novel neutralizing epitopes will help in designing better HIV envelope immunogens suitable for specific geographic regions where HIV-1 subtype C is prevalent.  Moreover, isolated HIV-1 neutralizing antibodies could also be used as a therapeutic agent to immunize HIV-1 infected individuals to reduce the viral burden. 

  • Huma Qureshi, Zhong-Min Ma, Ying Huang, Gregory Hodge, Michael A. Thomas, Janet DiPasquale, Veronique DeSilva, Linda Fritts, Andrew J. Bett, Danilo Casimiro, John W. Shiver, Marjorie Robert-Guroff, Michael N. Robertson, Michael B. McChesney, Peter B. Gilbert, Christopher J. Miller (2012), Penile SIVmac Challenge Of Ad5-Infected Macaques Immunized With an Ad5-Based Vaccine Recapitulates the Enhanced Infection Rate Among STEP Trial Vaccinees. (J Virol. 2012 Feb;86(4):2239-50. Epub 2011 Dec 7)
  • Qureshi H, Genescà M, Fritts L, McChesney MB, Robert-Guroff M, Miller CJ. Infection with Host-Range Mutant Adenovirus 5 Suppresses Innate Immunity and Induces Systemic CD4+ T Cell Activation in Rhesus Macaques. PLoS One. 2014 Sep 9;9(9):e106004. doi: 10.1371
  • Huma Qureshi*; Xavier Dervillez*; Aziz A. Chentoufi *; Arif A. Khan; Elizabeth Kritzer; David C. Yu; Oscar R. Diaz; Khaled W. Kabbara; Chetan Gottimukkala; Chelsea Nguyen; Min..a Kalantari; Maria C. Villacres; Vanessa M. Scarfone; John Sidney; Alessandro Sette; Anthony B. Nesburn; Steven L. Wechsler & Lbachir BenMohamed, Asymptomatic HLA A*0201-Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+T Cells from Seropositive Asymptomatic Individuals and Protect Against Ocular Herpes (J Immunol. 2013 Nov 15;191(10):5124-38.) * These authors contributed equally to this research.
  • Ma ZM, Keele BF, Qureshi H, Stone M, Desilva V, Fritts L,Lifson JD, Miller CJ (2011). SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma (AIDS Res Hum Retroviruses. 2011 Dec;27(12):1259-69)
  • Rothaeusler K, Ma ZM, Qureshi H, Carroll TD, Rourke T, McChesney MB, Miller CJ (2012). Antiviral antibodies and T cells are present in the foreskin of simian immunodeficiency virusinfected rhesus macaques. J Virol.Jul;86(13):7098-106. Epub 2012 Apr 24
  • Meritxell Genescà, Zhong-min Ma, Yichuan Wang, Basel Assaf, Huma Qureshi, Linda Fritts, Ying Huang, Michael McChesney, and Christopher Miller Live-Attenuated Lentivirus Immunization Modulates Innate Immunity and Inflammation While Protecting RM from Vaginal SIV Challenge J Virol. 2012 Sep;86(17):9188-200.

1. Isolation and chracterization of  of broadly neutralizing antibodies from HIV-1 Subtype C infected elite neutralizers.

1. Awarded Research fellowship from ICMR (Indian Council of Medical Research), India in year 2001.

2. Recipient of Research fellowship from CSIR (council of scientific and industrial research), India from year 2002-2007.

3. Recipient of travel Grant to attend AIDS vaccine 2006 meeting held in Amsterdam, Holland, Europe in year 2006.

4. Recipient of travel Grant by DBT to attend Institute of Human Virology annual meeting held in Baltimore USA in year 2006.