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People : Scientific : Faculty & Scientists

DR. BHABATOSH DAS, M.Tech., Ph.D. 

Assistant Professor
+91-129-2876471 
bhabatosh [at] thsti [dot] res [dot] in
2017: JSPS Fellow, Osaka University, Japan
2008-2011: CNRS Fellow, The Institute of Integrative Biology of the Cell, France
2006-2008: CSIR Research Fellow, Indian Institute of Chemical Biology, India
2003-2006: ICMR Research Fellow, Indian Institute of Chemical Biology, India
2001-2003: M.Tech., Biotech. & Biochem. Eng., IIT-Kharagpur, India

My current research focus is oriented to understand-

(i) The ecological principles of the microbial communities inhibiting in the human body and their role in health and diseases.

(iii) Role of gut microbiota in the emergence and spread of multidrug resistant (MDR) enteric pathogens.

(ii) How to resensitize MDR pathogens and commensal gut microbiota against routinely used antibiotics.

SELECTED PEER-REVIEWED PUBLICATIONS

2018

  • Das B.@,Ghosh TS., Kedia S., Rampal R., Saxena S., Bag S., Ridhima M., Dayal M., Mehta O., Surendranath A., Travis SPL., Tripathi P., Nair GB., Ahuja V. (2018). Analysis of the gut microbiome of Rural and Urban  Healthy Indians living in Sea level and High Altitude Areas.  Sci.  Rep. 2018 Jul 4;8(1):10104. PMID:29973712
  • Bag S., Ghosh T.S., Banerjee S., Mehta O, Verma J., Dayal M., Anbumani D., Kumar P., Saha B., Kedia S., Ahuja V., Ramamurthy T., Das B@. (2018). Molecular Insights into Antimicrobial Resistance Traits of Commensal Human Gut Microbiota. Mic. Ecol. Doi:10.1007/s00248-018-1228-7. PMID:30009332
  • Das B@., Verma J., Kumar P., Ghosh A., Ramamurthy T. (2018). Antibiotic Resistance in Vibrio cholerae: Understanding the Genesis and Mechanisms. Vaccine (Provisionally Accepted).
  • Sarkar S., Das B.@, Banerjee S.K.@. Insights into the Human Gut   Microbiome and Cardiovascular Diseases. J. Prac. Card. Sci. 2018;4:10-4.
  • Kumar A., Bag S., Das B@. Novel Genetic tool to study the stability of genomic islands. Rec. Pat. Biotech. 2018 May 4;4(1): 10-14.
    PMID:29473528
  • Ramamurthy T., Das B., Mukhopadhyay A., Debes AK., Chakraborty S., Sack D. (2018) Performance and diagnostic techniques for the detection of Cholera.   Vaccine (Provisionally Accepted)
  • Pant A., Das B., Bhadra RK. (2018). CTX phage of Vibrio cholerae: Genomics and applications. Vaccine (Provisionally Accepted).

 

2017

  • Das B@., Choudhuri S., Srivastava R., Nair G.B., Ramamurthy T. Fostering research into antimicrobial resistance in India. BMJ 2017;358:j3535 PMID:28877874
  • Bag S., Ghosh T.S., Das B@. Complete genome sequence of Faecalibacterium prausnitzii strain Indica isolated from the gut of a healthy adult Indian. Genome Announc. 16;5(46). pii: e01286-17. PMID:29146862
  • Bag S., Ghosh T.S., Das B@. Complete genome sequence of Collinsella aerofaciens strain Indica isolated from the gut of a healthy Indian. Genome Announc. 22;5(47). pii: e01361-17. doi: 10.1128/genomeA.01361-17. PMID: 29167267
  • Kumar P., Bag S., Dey P., Ghosh T.S., Dayal M., Saha B., Verma J., Saxena S., Pant A., Kumar D., Desigamani A., Rana P., Hanpude P., Maity T.K., Bhadra R.K., Sharma N.C., Nair G.B., Ramamurthy T., Das B. Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India Sci.  Rep.  2017 Oct 31;7(1):14468. PMID: 29089611
  • Bag S., Ghosh T.S., Das B@. Whole Genome Sequence of Megasphaera elsdenii strain Indica isolated from the gut of a healthy adult Indian. Genome Announc 5: e01033-17. PMID:29051237
  • Das A., Pereira V., Saxena S., Ghosh TS., Anbumani D., Bag S., Das B., Nair GB., Abraham P., Mande SS (2017) Gastric microbiome of Indian patients with Helicobacter pylori infection, and their interaction network. 2017, Sci.  Rep. 7, 15438. PMID:29133866
  • Bag S., Ghosh T.S., Das B@. Whole Genome Sequence of Bifidobacterium longum strain Indica isolated from the gut of a healthy adult Indian. Genome Announc. 5: e01017-17. PMID:29025929
  • Bag S., Ghosh T., Das B.@ Draft Genome Sequence of Prevotella copri isolated from the gut of a healthy adult Indian. Genome Announc. 5:e00834-17. PMID:28912310

 

2016

  • Das B., Pazhani G.P., Sarkar A., Mukhopadhyay A.K., Nair G.B., Ramamurthy T. Molecular Evolution and Functional Divergence of Vibrio cholerae. Curr. Opin. Infect. Dis. 2016, 29(5):520-7. PMID:27537830
  • Bag S.*, Saha B.*, Mehta O.*, D. Anbumani, Kumar N., Dayal M., Pant A., Kumar P., Saxena S., AllinK.H., Hansen T., Arumugam M., Vestergaard H.,Pedersen O., Pereira V., Abraham P., Tripathi R., Wadhwa N., Bhatnagar S., PrakashV.G., Radha V., Anjana R. M., Mohan V., Takeda K., Kurakawa T., Nair G.B., Das B.@ An Improved Method For Isolation Of High Quality Community Bacterial DNA From Human And Environmental Samples For Metagenomics Studies. Sci. Rep. 2016, 6, 26775
  •  Rakonjac J., Das B., and Derda R. Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Front. Microbiol. 2016, 7:2109 PMID:28066406.
  • Chowdhury G., Bhadra R.K., Bag S., Pazhani G.P., Das B., Basu P., Nagamani K., Nandy R.K., Mukhopadhyay A.K., Ramamurthy T.  Rugose atypical Vibrio cholerae O1 El Tor responsible for 2009 cholera outbreak in India. J. Med. Microb. 2016, 65: 1130-1136 PMID:27561681

2015

  • Pant A., Anbumani D., Bag S., Mehta B., Kumar P., Saxena S., Nair G. B., Das B.@ Effect of LexA on chromosomal integration of CTXfin Vibrio cholerae. J. Bacteriol.2015, 198:268-75. PMID: 26503849

2014

  • Das B.@ Mechanistic Insights Into Filamentous Phage Integration In Vibrio cholerae. Front. Microbiol. 2014, 5:650. PMID:25506341
  • Das B.@, Kumari R., Pant A., Sen Gupta S., Saxena S., Nair G.B. A Novel, Broad-Range, CTXΦ-Derived Stable Integrative Expression Vector For Functional Studies. J. Bacteriol. 2014, 196(23): 4071-80. PMID:25225263
  • Das B*, Banerjee R*, Nair G.B., Basak S. Dynamics in genome evolution of Vibrio cholerae. Infect Genet Evol. 2014, 23:32-41. PMID:24462909 (*equally contributed)
  • Das B.*,Midonet C.*,  Paly E., Barre F.X. XerD initiates the integration of TLCΦinto the Vibrio cholerae genome independently of FtsK. Proc. Natl. Acad. Sci. USA; 2014, 111 (47): 16848-16853.PMID:25385643  (*equally contributed)
  •  Das B., Nair G.B., Bhadra R.K. Acquisition and dissemination mechanisms of CTXΦ in Vibrio cholerae: New paradigm for dif residents. World J Med Genet. 2014, 4: 27-33.
  • Bag S., Das B., Dasgupta S., Bhadra R.K. Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis. Arch Microbiol. 2014,196(8):575-88. PMID:24859914
  • Kim E.J., Lee D., Moon S.H., Lee C.H., Kim S.J., Lee J.H., Kim, J.O., Song M., Das B., Clemens J.D., Pape J. W., Nair G.B., Kim D.W. Molecular insights into the evolutionary pathway of Vibrio choleraeO1 atypical El Tor variants. Plos pathogens. 2014, 0(9):e1004384. PMID:25233006
  • Ghosh T.S., Sen Gupta S., Bhattacharya T., Yadav D., Barik A., Chowdhury A., Das B., Mande S.S., Nair G.B. Gut Microbiomes of Indian children of varying nutritional status. PLoS One.2014,9:e95547 PMID:24763225

2013

  • Das B.,Martinez E., Midonet C., and Barre F.X. Integrative mobile elements exploiting Xer recombination. Trends Microbiol. 2014, 21:23-30. PMID:23127381.

2012

  • Pal R.R., Bag S., Dasgupta S., Das B., Bhadra R.K. Functional characterization of the stringent response regulatory gene dksA of Vibrio cholerae and its role in modulation of virulence phenotypes. J. Bacteriol. 2012, 194(20):5638-48.PMID:22904284

2011

  • Das B.,Bischerour J., Barre F.X. VGJFintegration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains. Proc.Natl. Acad. Sci, USA. 2011, 108:2516-2521. PMID:21262799
  • Das B., Bischerour J., Barre F.X. ­Molecular mechanism of acquisition of the cholera toxin genes. Indian J. Med. Res. 2011, 133:195-200.PMID:21415494.
  • Pal R.R., Das B., Dasgupta S., Bhadra R.K. Genetic components of stringent response in Vibrio cholerae. Indian J. Med. Res. 2011,133:212-217. PMID:21415497.
  • Majumdar T., Das B., Bhadra R.K., Dam B., Mazumder S. Complete nucleotide sequence of a quinolone resistance gene (qnrS2) carrying plasmid of Aeromonas hydrophila isolated from fish. Plasmid. 2011, 66:79-84. PMID:21664930.

2010

  • Das B.*, Bischerour J*., Val M.E., Barre F.X. Molecular keys of the tropism of integration of the Cholera Toxin phage. Proc.Natl. Acad. Sci, USA 2010, 107:4377-4382. (Commentary in PNAS). 
  • Halder K., Das B., Nair G. B., Bhadra R.K. Molecular evidences favouring stepwise evolution of Mozambique Vibrio cholerae O1 El Tor hybrid strain. Microbiology(SGM) 2010, 156:99 107. 

2009

  • Das B.,Pal R.R., Bag S., Bhadra R.K. Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene. Mol. Microbiol. 2009. 72:380-398. PMID:19298370.

2008

  • Das B.,Bhadra R.K. Molecular characterization of Vibrio cholerae ΔrelA ΔspoT double mutants. Arch. Micrbiol. 2008,189:227-238. PMID:17968531.
  • Shah S., Das B., Bhadra R.K. Functional analysis of the essential GTP-binding protein coding gene cgtA of Vibrio cholerae. J. Bacteriol. 2008, 190:4764-4771. PMID:18456812.
  • Bhowmick R., Ghosal A., Das B., Koley H., Saha D. R., Ganguly S., Nandy R.K., Bhadra R.K., Chatterjee N.S. Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin. Infect. Immun. 2008, 76:4968-4977.PMID:18765724.

2007

  • Das B.,Halder K., Pal P., Bhadra R.K. Small chromosomal integration site of classical CTX prophage in Mozambique Vibrio cholerae O1 biotype El Tor strain. Arch.Micrbiol. 2007, 188:677-683. PMID:17618421.

2006

  • Maiti D., Das B.,Saha A., Nandy R.K., Nair G.B., Bhadra R.K. Genetic organization of the pre-CTX and CTX prophages in the genome of an environmental Vibrio cholerae non-O1, non-O139 strain. Microbiology (SGM) 2006, 152:3633-3641.PMID:17159216.

 

Research in News

(1) The Hindu (26th August 2018)

Title: A nursery of drug resistance

https://www.thehindu.com/sci-tech/health/a-nursery-of-drug-resistance/article24782373.ece

 

(2) BusinessLines (21st August 2018)

Gut bacteria are a reservoir of drug resistance genes: study

https://www.thehindubusinessline.com/news/science/gut-bacteria-are-a-reservoir-of-drug-resistance-genes-study/article24744954.ece

 

(3) Nature India(29 July 2018)

Pathogens pick up drug resistance genes from friendly bacteria

https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.95

 

(4) Nature India (July11, 2018)

Rural Indians have healthier guts than urban folks

https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.88

 

(5) Dept. of Biotechnology, Govt. of India (July 23, 2018)

Richness, functions and diversity of the gut microbiome of healthy Indians

http://www.dbtindia.nic.in/gut-microbiome-of-healthy-indians/

 

(6) Vigyan Prasar, Dept. of Science and Technology, Govt. of India (July 19, 2018)

A peek into gut of Indians throws up surprises

http://vigyanprasar.gov.in/isw/peek_into_gut_indians_throwsup_surprises_story.html

 

(7) The Hindu (July 22, 2018)

What your gut is telling you

https://www.thehindu.com/sci-tech/health/what-your-gut-is-telling-you/article24485083.ece

 

(8) Hindustan Times (July 22, 2018)

Vegetarian diet helps keep Indian gut healthy: Study

https://www.hindustantimes.com/health/vegetarian-diet-helps-keep-indian-gut-healthy-study/story-9fEx1ypTnvOlm1y9zoJKzL.html

 

(9) Deccan Herald (23rd July, 2018)

Scientists map gut microbiota of Indians

https://www.deccanherald.com/national/scientists-map-gut-microbiota-682983.html

 

(10) The Hindu (15th October 2017)

We need to talk about AMR

https://www.thehindu.com/todays-paper/tp-opinion/we-need-to-talk-about-amr/article19864066.ece

 

(11) Fountain ink (17th May 2017)

The body’s secret garden: How the exploration of the microbiome is going to change face of medicine

https://fountainink.in/reportage/the-body039s-secret-garden

 

(12) Dept. of Biotechnology, Govt. of India (2015)

Scientists in THSTI Develop Novel Genetic Tools to speed up Drug Discovery Research

http://www.dbtindia.nic.in/scientists-in-thsti-develop-novel-genetic-tools-to-speed-up-drug-discovery-research/

 

(13) Times of India (Aug 17, 2015)

Research roundup: Vector-wise

https://timesofindia.indiatimes.com/home/education/news/Researcg-roundup-Vector-wise/articleshow/48511390.cms

 

 

Book/Book Chapter

  • eBook (2017): Filamentous Bacteriophage in Bio/Nano/Technology, Bacterial Pathogenesis and Ecology. Edited by: Jasna Rakonjac, Bhabatosh Das, Ratmir Derda. Publisher: Frontiers Media SA. ISBN: 9782889450954
  • Dasgupta S., Das B., Basu P., Bhadra R.K. (2016) Molecular basis of stringent response in Vibrio cholerae (Edited by Frans J. de Bruijn. John Wiley & Sons, Inc, USA). P. 507-516 Aug 2016
  • Nair G.B., Sen Gupta S., Das B.(2014). The “Uncultured” but significant world of the human gut microbiome: New metagenomic insights. In G. P. Talwar and L.M. Srivastava (Eds.), Textbook of Biochemistry and Human Biology (pp. 664-671). Delhi, India: PHI Learning Pvt. Ltd.
  • Das B.and Nair G.B. (2012). The genomics of Cholera. In ‘Genomics Applications for the Developing World’ (Eds. Karen E. Nelson & Barbara jones-Nelson) Springer publication, USA pp. 21-38, DOI: 10.1007/978-1-4614-2182-5_3.
  • Bhadra R.K., Shah S., Das B.(2010). Small Molecule Signaling Systems in Vibrio cholerae.  In ‘Epidemiological and Molecular Aspects on Cholera’ (Eds. Ramamurthy T. & Bhattacharya S. K.). Humana Press, USA, pp. 185-201.
  • Bhadra R.K. and Das B.(2008). Coordinated regulation of gene expression in Vibrio cholerae. In ‘Vibrio cholerae: Genomics and Molecular Biology’ (Eds. Faruque, S.M. & Nair, G.B). Caister Academic Press, UK, pp. 153-167.

 

 

  • BMGF Travel Grant Award to attend 52nd US-Japan Joint Panel Conference on Cholera and Other Bacterial Enteric Infections (2018)

  • Japan Society for the Promotion of Science (JSPS) Invitational Fellowship Award (2017). 

  • Invited Member in World Health Organization (WHO) Expert Group for Developing “Target Product Profile for cholera Rapid Diagnostic Tests, 2017
  • Young Investigator Award (1st prize) from Yakult India Microbiota and Probiotic Science Foundation, 2016

Adjunct Visiting Faculty at Kasturba Medical College, Manipal University, Manipal

Editorial Board Member

  • Frontiers in Microbiology

            (Nature publishing group)

  • Microbial Ecology

           (Springer)