People : Scientific : Faculty & Scientists

DR. AANCHAL SHARMA, Ph.D. 

Scientist C
+91-129-2876481 
aanchal [at] thsti [dot] res [dot] in
Ph.D. Biotechnology, National Centre for Cell Science, University of Pune
M.Sc. Biotechnology, MS University of Baroda
B.Sc. Biomedical Science, University of Delhi

Research  Interest:

The objective of the lab is to develop, optimize and validate in vitro cell free enzyme and cell based assays for hit to lead identification of small molecules in drug discovery programs. By using various platforms like TR-FRET, Luminescence and biochemical & immunologist techniques, we try to establish and validate bioassays for in vitro screening of NCEs (New Chemical Entities).

Research Experience:

Research Scientist (2011-2017)

Department of Pharmacology, Daiichi Sankyo India Pharma Pvt Ltd., Gurgaon

Research Associate (June -Sep2011)

VIDRC, THSTI, Faridabad

 

  • Meena AS, Sharma A, Kumari R, Mohammad N, Singh SV, Bhat MK (2013) Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PLoS One 8(4) e61524
  • Sharma A and Bhat MK (2011). Enhancement of drug mediated and quercetin induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells. Integrative Cancer Therapies 10 (4), NP4-14
  • Sharma A, Meena AS and Bhat MK (2010) Hyperthermia associated carboplatin resistance: Differential role of p53, HSF1 and Hsp70 in hepatoma cells. Cancer Science 101:5, 1186
  • Sharma A, Upadhay AK, Bhat MK (2009) Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell death in hepatoma cells. Cancer Biology and Therapy 8:22, 2104
  • Kumari R, Sharma A, Ajay, AK and Bhat MK (2009) Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models. Molecular Cancer 8:87
  • Aher NG, Pore VS, Mishra NN, Kumar A, Shukla PK, Sharma A, Bhat MK (2009) Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. Bioorganic & Medicinal Chemistry Letters 19:759
  • Team of the year award for diligently performing the IND (Investigational New Drug) studies in the fiscal year 2012-2013 at Daiichi Sankyo India Pvt. Ltd.
  • Star Team award for proactive involvement in setting up the database, IDBS in the fiscal year 2012-2013 at Daiichi Sankyo India Pvt Ltd.
  • Won 1st Best Poster Award at 3rd International Symposium on Translational Cancer Research organized by Society for Translational Cancer Research held at Bhubaneswar in December'2009
  • Qualified CSIR-UGC National Eligibility Test (NET), India 2005
  • Member of the editorial board of GSL Journal of Vaccines and Vaccination 
  • 6-month certificate course in “Clinical Research” from Symbiosis Institute of Health Science, Pune, 2009