News

Dr. Amit Awasthi receives the 2017 Early Career Faculty Travel Grant from AAI


Posted on: 2017-03-16

Dr. Amit Awasthi receives the 2017 Early Career Faculty Travel Grant from the American Association of Immunologists (AAI). The travel grant supports travel to the annual AAI event.

Dr. Amit Awasthi is elected to the executive committee of the Indian Immunology Society(IIS)


Posted on: 2017-03-10

Dr. Amit Awasthi, Associate Professort at CHME has been elected to the executive committee of the Indian Immunology Society. He has been awarded the GP Talwar Mid Career Scientist Award for the year 2016 at the 43rd Immunocon held in Vishakapatnam . The award is given for original immunological work done in India for members of the Indian Immunology Society. The award carries a certificate of honor, medal and cash prize.

Dr. Jayanta Bhattacharya awarded with the Indo-South A​frica​ Collaborative Research Program


Posted on: 2017-03-09

Dr. Jayanta Bhattacharya, Principal Investigator at the HIV ​V​accine ​Translational ​Research ​Laboratory has been awarded ​with ​the Indo-South ​A​frica​ Collaborative Research Program on Health Sciences with Emphasis on TB HIV & AIDS for his proposal titled "Isolation and Characterization of Monoclonal Antibodies from HIV-1 Subtype C Infected Individuals​ (http://www.dbtindia.nic.in/list_tb_hiv_aids/​)​. This is in collaboration with Prof. Lynn Morris, National Institute of Communicable Diseases (NICD), Johannesburg.​ The proposed collaborative programme ​will be under the framework of bilateral Science and Technology Cooperation Agreement between the Department of Science and Technology, Ministry of Science and Technology, Governments of India and South Africa.​ ​
http://www.dbtindia.nic.in/list_tb_hiv_aids/

5th Molecular Virology Meeting at THSTI


Posted on: 2017-02-22

The 5th Molecular Virology meeting was held at THSTI on 11th and 12th February 2017. The meeting brought together leading researchers working on different aspects of Virology. The meeting covered both basic and applied research and provided a platform to discuss latest developments in areas of host-virus interactions, immune responses and vaccine development, molecular biology, evolution and epidemiology of viruses and emerging therapeutics and diagnostics. The meeting included poster presentation by the students from various institutes.

Best Poster Presentation Award: Mr.Parameshwar Katare-DDRC


Posted on: 2017-02-20

Mr. Parmeshwar Katare,PhD student with Dr. Sanjay Kumar Banerjee, DDRC has bagged the best poster presentation award for the research work entitled “Sulfur Metabolites from Garlic Activate SIRT-3 to Prevent Mitochondrial Dysfunction in Diabetic Heart” in the 14th annual meeting of International Society of Heart Research, (ISHR) Indian section held from 27th to 29th January 2017 at the CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

Science SETU between THSTI and Acharya Narendra Dev College


Posted on: 2017-02-20

THSTI faculty from the virology group of VIDRC visited Acharya Narendra Dev College on 14th and 15th Feb 2017 as part of the science SETU program.The program had scientific lectures and interactive sessions.

THSTI connects with students of Maitreyi College, New Delhi through Science Setu


Posted on: 2017-02-07

As part of implementation of the Science Setu program, the faculty and scientists of THSTI from the Drug Discovery Research Centre (DDRC) and Vaccine and Infectious Disease Research Centre (VIDRC) visited Maitreyi College, New Delhi on 18th October 2016 and on 24th and 25th January 2017 for interaction with students and teachers. Presentations and discussions covered topics from systems biology, conceptual understanding of the language of biology, vaccines and drugs for tuberculosis, biology of viruses, host-virus interactions and current and future prospects of virology.

Dr Sagarika Haldar receives the Global Health Travel Award funded by the Bill & Melinda Gates Foundation to attend and present awarded research work at the Keystone Symposium


Posted on: 2017-01-31

Dr Sagarika Haldar received the Global Health Travel Award funded by the Bill & Melinda Gates Foundation to attend and present awarded research work as a poster entitled Utility of Mycobacterium tuberculosis antigens derived from serum and serum derived exosomes for the diagnosis of Extrapulmonary Tuberculosis at the Keystone Symposium: A5, New Developments in Our Basic Understanding of Tuberculosis held at the Fairmont Hotel Vancouver in Vancouver, British Columbia, Canada on January 14 – 18, 2017.

THSTI files for patent on the diagnostic platform and therapeutics based on novel HupB aptamers


Posted on: 2017-01-30

THSTI and AIIMS have recently filed an Indian provisional patent application on novel aptamers against mycobacterial nucleoid-associated protein HupB and uses thereof. A team of researchers from THSTI and AIIMS led by Prof. Jaya S. Tyagi and including Dr. Hanumanthappa Krishna Prasad, Dr. Tarun Kumar Sharma, and Priya Kalra, is working on establishing use of these novel HupB aptamers in rapid and accurate diagnosis of TB in humans and as therapeutic agent in anti-TB pharmaceutical compositions.

THSTI organized 2nd Board Meeting of Global Coalition for Epidemic Preparedness Innovations (CEPI)


Posted on: 2017-01-30

The Department of Biotechnology, Government of India entrusted THSTI for organizing 2nd Board Meeting of Global Coalition for Epidemic Preparedness Innovations (CEPI) in India on December 15-16, 2016 in Hotel Taj Palace, New Delhi.
The CEPI focuses on the development of new vaccines for known and unknown pathogens and being a founder of the coalition, DBT was hosting the second meeting of the CEPI.
THSTI organized a Scientific Meeting on the “Role of the India Vaccine Industry in Global Public Health” on December 15, 2016 followed by the Second Meeting of the CEPI on December 16, 2016.
Honble Cabinet Minister for Science & Technology and Earth Sciences, Government of India, Dr. Harsh Vardhan was Chief Guest in the event. The event was attended by Dr. Vijaya Raghavan, Secretary, DBT and Dr. Jeremy Farrar, Director, Wellcome Trust along with more than 30 delegates from India and abroad.

US delegates visited THSTI exploring collaboration opportunities


Posted on: 2017-01-27

Speakers at International Seminar on Technology Transfer as a Tool to optimize IP and Innovation organized by National Development and Research Centre (NDRC) on 9th January, 2017 visited THSTI on 10th January, 2017 to explore collaboration opportunities.

Ms. Nina Vaskunlahti, Finnish Ambassador visits THSTI


Posted on: 2017-01-26

THSTI is one of the locations for the Indo-Finnish Diagnostic Research Centre (IFDRC) which is collaboration between University of Turku, Finland and THSTI and set-up to complement and enhance the research capabilities of its Indian and Finnish scientific networks from academia and industry in the area of diagnostics.
Her Excellency Ms. Nina Vaskunlahti, Ambassador of Finland visited THSTI on January 10, 2017 showing her interest in the projects going on at THSTI under this Indo-Finnish Co-operation.

Shortlisted for talk at Proteomics Society of India Meeting (PSI 2016)


Posted on: 2017-01-23

Mr. Puneet Kumar Kadimi, Research Application Developer, in DDRC, working with Dr. Amit Kumar Yadav was shortlisted for an Oral talk on his research work titled A Browser-based Interactive Dashboard for Exploratory Analysis of MS-based Proteomics data at the 8th Meeting of PSI and the 3rd Meeting of AOAPO hosted at New Delhi, India from 14-17th Dec 2016.

International Travel Award from Joint International Tropical Medicine Meeting 2016 (JITMM-2016), Bangkok


Posted on: 2017-01-20

Dr. Chandresh Sharma (Innovation Awardee) and Ms. Tarang Sharma (PhD Student) at the Center for Bio-Design and Diagnostics (CBD), THSTI, have bagged the International Travel Award in the conference Joint International Tropical Medicine Meeting 2016 (JITMM-2016), Uncover Asian Tropical Medicine, from 7-9 December 2016, held at Amari Watergate, Bangkok, Thailand.
Dr. Chandresh gave a Turbo talk and poster presentation on his work titled, Developing a Rapid Test for Improved Diagnosis of Typhoid Fever, while Ms. Tarang Sharma has received the JITMM 2016 Travel Grant for presenting her research work titled Unravelling the host specificity of Salmonella infection by comparative secretome profiling.

Dr. Shinjini Bhatnagar is awarded Fellow of National Academy of Medical Sciences


Posted on: 2017-01-19

National Academy of Medical Sciences (India) is a unique institution which fosters and utilizes academic excellence as its resource to meet medical and social goals. It was registered as the Indian Academy of Medical Sciences on 21st April, 1961 under Societies Registration Act XXI of 1860.
Over the years the Academy has recognized the outstanding achievements made by the Indian scientists in the field of medicine and allied sciences and conferred Fellowship as well as Membership to the selected persons through a peer reviewed process and finally voting by all the Fellows.
Dr. Shinjini Bhatnagar, Dean, Clinical Research, Head, Pediatric Biology Centre has been awarded Fellow of the National Academy of Medical Sciences for 2016.

Award of PhD degrees


Posted on: 2017-01-16

Mr. Manish Sharma and Ms. Minu Nain, Research Scholars of VIDRC Molecular Virology Lab successfully defended their PhD thesis and were awarded their degrees from Jamia Hamdard.
They have the proud distinction of being the first two PhD scholars from THSTI.

Short listed for talk in World Congress on Drug Discovery and Development


Posted on: 2016-12-23

Mr. Mrityunjay Singh, SRF, in DDRC, under the supervision of Dr. Shailendra Asthana was short listed for a talk on his research work titled “Molecular modeling of the disordered regions of Sirt-1 to understand the atomistic protein-protein interaction mechanism” in the World Congress on Drug Discovery and Development in the Indian Institute of Sciences (IISc) Bengaluru, between 23rd and 25th November, 2016. He won the “Best Presentation Award” for his presentation.

International travel grant from RSG-Germany Student Symposium on Computational Genomics


Posted on: 2016-12-23

Mr. Mitul Srivastava, SRF, in DDRC, under the supervision of Dr. Shailendra Asthana won “International Travel Grant” for presenting his research work titled “A protein-protein interaction approach to unravel the mechanism of protein rescue and degradation” at RSG-Germany Student Symposium on Computational Genomics in the Institute of Molecular Biology, Mainz, Germany on 29th and 30th November, 2016. His research work was highlighted as best abstract for flash presentation.

THSTI filed for patent on method of mass spectrometry involving novel multiplexing technique


Posted on: 2016-12-19

THSTI filed for patent on a method of mass spectrometry for quantitatively studying multiple proteome samples (18-plex) in a single shot of mass spectrometry experiment. The method and informatics tools enable better, reliable, and efficient quantitation with reduced technical variability and increased multiplexing capacity at the same time.
The technology is developed by DDRC team led by Dr. Amit Kumar Yadav including Dr. Ajay Kumar, Dr. Shilpa Jamwal, Suruchi Aggarwal and Dr. Kanury Rao.

Nature India covers the research conducted by Dr. Awasthi’s laboratory on the association of dietary potassium with the susceptibilty of Crohn’s disease and ulcerative colitis.


Posted on: 2016-12-18

This study is an outcome of collaborative research between THSTI, Massachusetts General Hospital, Boston Children Hospital, Johns Hopkins Medical Centre, and Channing Division of Network Medicine. This is the first ever study suggesting extracellular potassium induced T cell tolerance by inducing the generation of Foxp3+ Treg cell in humans.
The article titled “Identification and characterization of a novel association between dietary potassium and risk of Crohn’s disease and Ulcerative colitis” is authored by Hamed Khalili, Sakshi Malik, Ashwin N. Ananthakrishnan, John J. Garber, Leslie M. Higuchi, Amit Joshi, Joanna Peloquin, James M. Richter, Kathleen O. Stewart, Gary C. Curhan, Amit Awasthi, Vijay Yajnik and Andrew T. Chan.
The Telegraph (http://www.telegraphindia.com/1161209/jsp/nation/story_123797.jsp)
Indian Express (http://indianexpress.com/article/lifestyle/health/for-inflamed-bowels-solution-could-lie-in-potassium-intake-4422435/)
http://www.natureasia.com/en/nindia/article/10.1038/nindia.2016.159

Ms. Bhavya Khullar, has won second position in FameLab India North


Posted on: 2016-12-12

Ms. Bhavya Khullar, has won second position in FameLab India North

Bhavya Khullar, PhD student of Dr. Shailaja Sopory at Pediatric Biology Center,THSTI has been selected to participate and compete in the FameLab India this year.


Posted on: 2016-11-25

FameLab is one of the biggest science communication competitions in the world!!
FameLab is a training programme in a competition format to get people talking about science, technology, engineering, maths and medicine. A bit like X-Factor, really, but with a slightly more intelligent slant to it. There are four basic stages: regional heats, regional final, masterclass, and national final, with the eventual winners being invited to travel to the UK and participate in the Cheltenham Science Festival. Applicants have three minutes to present a concept from their field of study to a panel of judges. Make it funny, make it dramatic, make it jaw-dropping, eye-opening, lightbulb-poppingly brilliant. It’s entirely up to how creative you’re feeling. The judges look for somebody who can shine in content, clarity and charisma (in other words it has to be scientifically accurate, clear to understand and presented with a wink and a smile).
https://www.britishcouncil.in/programmes/higher-education/famelab

Prof. Gagandeep Kang, Executive Director has been awarded the Infosys Prize 2016 in the field of Life Sciences


Posted on: 2016-11-18

For details visit:
http://www.infosys-science-foundation.com/prize/laureates/2016/index.asp

Prof. Gagandeep Kang has taken charge as the new Executive Director of THSTI.


Posted on: 2016-08-16

Prof. Gagandeep Kang, Professor of Microbiology and Head of the Wellcome Trust Research Laboratory (WTRL), and Division of Gastrointestinal Sciences at Christian Medical College (CMC), Vellore, has taken charge as the new Executive Director of Translational Health Science and Technology Institute (THSTI), Faridabad, on Aug. 16, 2016. Over the past 20 years, Prof. Kang has built a strong inter-disciplinary research and training program, where young faculty and graduate students are mentored before embarking on independent research careers. She leads a multi-disciplinary research team that conducts comprehensive and complementary studies in the description, prevention and control of diarrheal disease using state-of-the-art tools in the laboratory, hospital and the field.
Prof. Kang is an Associate Editor for PLoS Neglected Tropical Diseases and Tropical Medicine and International Health, and serves on the editorial board of Nature Scientific Reports as well. She is a Council Member of the International Society for Infectious Diseases and an Independent Director of the Biotechnology Industry Research Assistance Council. Her expertise in vaccines is underlined by her membership of the National Technical Advisory Group on Immunization, the WHOs Global Advisory Committee on Vaccine Safety, and the WHOs Immunization and Vaccine Implementation Research Advisory Committee, as well as chairing the WHO SEARs Immunization Technical Advisory Group.

THSTI scientist lauded for twin achievements


Posted on: 2016-08-15

Dr. Sameena Khan of DDRC has been selected as an Associate of the Indian Academy of Sciences. The associates program was initiated by the academy in 1983 to encourage talented young scientists, below the age of 35 years, who are working in India. The intent is also to induct such young people into different programmes of the academy.
Dr. Khan has also been selected for the NASI Young Scientist Platinum Jubilee Award in Biological Sciences for 2016. This award, conferred by the National Academy of Sciences, India, is in recognition of Dr. Khan’s promise, creativity, and excellence as a young scientist. The award will be presented to her during the valedictory function of the 86th Annual Session of the academy. Dr. Sameena Khan had previously also bagged the INSA Medal for Young Scientist Award in 2015.

Dr. Amit Awasthi, Assistant Professor, CHME, has received the American Association of Immunologists (AAI) travel grants.


Posted on: 2016-07-08

Dr. Amit Awasthi, Assistant Professor, CHME, has received the following grants:
The 2016 American Association of Immunologists (AAI) Early Career Faculty travel grant to attend the annual meeting of AAI in Seattle, USA.
The American Association of Immunologists (AAI) travel grant to attend the International Congress of Immunology in Melbourne, Australia.

THSTI faculties receive Biotechnology Ignition Grant-in-Aid


Posted on: 2016-06-28

BIRAC has accepted two proposals submitted by THSTI faculties under 8th call of the Biotechnology Ignition Grant BIG Scheme (1st Jan – 15th Feb, 2016). One proposal is on Strip-based Typhoid Diagnostics, through a start-up company founded by Dr. Susmita Chaudhuri and Dr. Niraj Kumar working in the Centre for Biodesign and Diagnostic (CBD), THSTI. Another proposal is on aptamer-based TBM Diagnostics, from Dr. Tarun Kumar Sharma, also a part of CBD, THSTI.

New Indian Provisional Patent Application on TBM diagnosis using aptamers


Posted on: 2016-06-28

THSTI and AIIMS have recently filed their second provisional patent application on novel aptamers which are experimentally proved to be used efficiently against M.tb malate synthase, an enzyme essential for persistence of M.tb in human body. A team of researchers from THSTI and AIIMS led by Prof. Jaya S. Tyagi and including Dr. Tarun Kumar Sharma, Dr. Chanchal Kumar, Abhijeet Dhiman, and Ishara datta, is working on screening novel aptamers which will have application in diagnosis and treatment of Tuberculosis in Humans. The first filing under this collaborative research was in February, 2016 on novel aptamers against HspX antigen and the technology is already licensed for translation into a market ready product.

Dr. Gaurav Batra receives grant from the Wellcome Trust for the development of ultrasensitive diagnostic test for blood borne infections


Posted on: 2016-06-22

Dr. Gaurav Batra (Centre for Biodesign and Diagnostics, THSTI), in collaboration with ICGEB, University of Turku, Finland and two industrial partners, has received funding from the Wellcome Trust, UK to develop a novel, multiplexed Point of Care Test (POCT) for the detection of HIV, HCV and HBV infections. Dr. Gaurav Batra is the Principal Investigator and the coordinator of this multi-institutional project.
The performance of commercially available rapid POCTs for HIV, HCV and HBV is very poor compared to central lab tests (ELISA etc) and there is an urgent need for highly sensitive and specific, rapid, field-deployable multiplex tests for these blood borne infections. A multiplexed high sensitivity POCT for HIV, HCV and HBV will find utility in Emergency settings, Population screening, blood bank, STI clinics and Antenatal screening.

DDRC, RBPL partner to explore new possibilities in diabetes research


Posted on: 2016-04-06

The Drug Discovery Research Centre (DDRC), a niche Centre of the Translational Health Science and Technology Institute of the Department of Biotechnology, Govt. of India, and Revelations Biotech Pvt. Ltd. (RBPL), a Hyderabad based Research and Development Company, have entered into a research collaboration to develop new approaches for diagnosis and treatment of diabetes.
The Minister of State for Science & Technology and Earth Sciences, Shri Y.S. Chowdary, presided over the Memorandum of Agreement (MoA) signing ceremony which took place at Prithvi Bhawan, New Delhi. While addressing the crowd, the Minister said that India stands out as the diabetic capital of the world which is a cause of serious concern. Shri Chowdary also laid emphasis on the importance of Translational Research to facilitate translation of cutting edge research works by scientists in their labs to manufacturing low cost drugs for the masses, with sufficient contribution from the private sector. He reiterated on the importance of finding a preventive measure to diagnose and combat the incidence of diabetes at an early stage.
As many as 50 million people suffer from type-2 diabetes in India. The annual expenditure for diabetes treatment in the country is to the tune of Rs. 1.5 lakh crores. Diabetes is a chronic progressive metabolic disorder of multiple etiologies that is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism. Although previously thought to represent a problem of ‘middle-age’ the alarming trend seen in recent years is a rapid rise in incidence of this disease in the younger population. This is largely due to lifestyle changes where a high calorie diet is coupled with sedentary habits. Importantly, the expanding dimension of this disease emphasizes the urgent need for more sensitive methods for detection, and also for more effective regimens for treatment.
Prof. K. VijayRaghavan, Secretary, Department of Biotechnology, Govt. of India, lauded the DDRC-RBPL collaboration. He stressed that the focus on addressing these needs will be meted out through two separate programs. The goal of one of these programs is to develop a data based software package that will not only identify individuals/youth who are becoming susceptible to diabetes, but also predict future course of disease in those who are already diabetic. It is anticipated that the advance warning provided by such a system will allow the target individuals to pre-emptively make the appropriate lifestyle alterations so as to mitigate disease development, and prevent its progression. The second program is to develop a new drug that will prevent reabsorption of glucose in the kidneys. This reabsorption process contributes to maintaining the high glycemic levels in diabetics. Inhibition of this process by an effective drug therefore will lead to a significant lowering of the blood glucose level.

THSTI faculty shines at MPAI, 2016


Posted on: 2016-03-29

Dr. Sagarika Haldar, DST INSPIRE Faculty at the Center for Bio-design & Diagnostics (CBD), bagged the 1st prize in the poster session on Infectious Diseases in the 5th Annual Conference of the Molecular Pathology Association of India (MPAI) and International Symposium “Integration of Genetics and Genomics in Laboratory Medicine”. The event was held on March 12-13, 2016 at the PGIMER, Chandigarh.
The poster, entitled “Rapid detection of multi drug resistance in Mycobacterium tuberculosis directly from smear negative sputum samples by High Resolution Melt curve analysis”, was co-authored by Divya Anthwal, Rakesh Kumar Gupta, Manpreet Bhalla, and Jaya Sivaswami Tyagi.

DDRC bags prestigious IUSSTF Award


Posted on: 2016-02-22

The Drug Discovery Research Center (DDRC) of THSTI has been conferred with the prestigious Indo-US Science and Technology Forum (IUSSTF) Award, 2015. The IUSSTF, established under an agreement between the Government of India and the United States of America in March, 2000, aims to promote and catalyze Indo-US bilateral collaborations in the fields of science, technology, engineering, and biomedical research through substantive interaction between government, academia and industry. Its principle objective is to provide opportunities to exchange ideas, information, skills and technologies, and to collaborate on scientific and technological endeavor of mutual interest that can translate the power of science for the benefit of mankind at large. With this in mind, a joint proposal between DDRC and Department of Radiation Oncology, Stanford University, USA was considered under Call-II of IUSSTF, 2015, and based on peer reviews, a two-year financial support has been agreed upon for the same. The Centre for Integrative Biology of Non-Communicable Diseases (CIBN) will act as the joint center while DDRC and the Department of Radiation Oncology, Stanford University, USA will serve as the nodal host institution.

THSTI scientist wins Young Investigator Award


Posted on: 2015-12-18

Dr. Shailendra Asthana, Scientist-C at the Drug Discovery Research Center, THSTI, Faridabad, has received the Young Investigator Award-2015 for his research work titled, “Small molecule modulation of Sirt1 activity by targeting its unstructured disordered N-terminal” at the Conference on Bioinformatics and Computer Aided Drug Design (CBCADD)-2015, recently held at IIT Guwahati, from Dec. 6-8, 2015. Dr. Asthana was also felicitated with the DST-SERB Start-Up Young Scientists Research Grant-2015 for his project titled, "Functional characterization of finger loop with/without inhibitors in HCV RNA-Dependent RNA Polymerase: A microscopic picture through computational simulations and its application for new antiviral drug development".

THSTI shines at ACBICON-2015


Posted on: 2015-12-11

Dr. Anurag Sankhyan and Dr. Chandresh Sharma, Innovation Awardees at the Center for Bio-Design and Diagnostics, THSTI, Faridabad, have bagged the ACBI-IFCC TFYS Young Scientist Award-2015, and M. G. I. M. S. (Sevagram) Award, respectively at ACBICON-2015, held at P.G.I.M.E.R., Chandigarh from Nov. 26-28, 2015. While Dr. Sankhyan bagged the award for his research work titled, "An array of human recombinant antibodies from naturally recovered individuals for inhibition of preS1-hepatocyte interaction", Dr. Sharma received the accolade for his paper titled “Generation of monoclonal antibodies specific to S. typhi as a potential candidate for improved typhoid diagnostics”. The event also saw another member of THSTI, Ms. Tarang Sharma, PhD Student of Dr. G. B. Nair and Dr. Ashutosh Tiwari (Center for Bio-Design and Diagnostics) being felicitated with the Organizing Committee Award for Excellent Poster Presentation for her poster titled “Development of a Robust and Efficient Diagnostic test for acute Typhoid fever”.

Scientist felicitated at BPCON 2015


Posted on: 2015-12-11

Dr. Sanjay K Banerjee, (Scientist E) at the Drug Discovery Research Center, THSTI, Faridabad, has been awarded with the prestigious Prof. Shailendra K Vajpeyee Award, 2015 for his research work titled “Role of Nitric Oxide on Hypertension in Diabetes: A Study from bench to Bed”. He presented his work at the 25th Annual Conference of the Indian Society of Hypertension (Silver Jubilee BPCON 2015, Faridabad), which was organized by the ESIC Medical College & Hospital, Faridabad from Nov. 20 -22, 2015. Dr. Banerjee is currently engaged in research to find novel targets and therapeutic interventions to reduce cardiovascular complication in diabetes at THSTI.

2nd Meeting of Global Task Force on Cholera Control (GTFCC)


Posted on: 2015-11-26

2nd Meeting of Global Task Force on Cholera Control (GTFCC)

Vigilance Awareness Week 2015


Posted on: 2015-10-30

Vigilance Awareness Week 2015

हिन्दी सप्ताह समारोह 2015


Posted on: 2015-09-21

प्रत्येक वर्ष की भाँति संस्थान में इस वर्ष भी हिन्दी सप्ताह समारोह 14 से 21 सितम्बर 2015 के मध्य आयोजित किया गया| सप्ताह के मध्य सभी वैज्ञानिकों, अधिकारियों, कर्मचारियों एवं छात्रों को केवल हिन्दी में बात करने तथा अपना वैभागिक कार्य हिन्दी में करने के लिए प्रेरित किया गया|
समारोह के मध्य पूरे सप्ताह भर विभिन्न हिन्दी कार्यक्रम आयोजित किए गये जैसे स्वयं द्वारा रचित हिन्दी कविता पाठन, किसी तात्कालिक दिए गये विषय पर हिन्दी में अपने विचार व्यक्त करना, निबंध लेखन इत्यादि| सभी कार्यक्रमों के सफल अयोजन हेतु संस्थान के अधिष्ठाता (अकादमी) एवं अधिष्ठाता (नैदानिक शोध) के मार्गदर्शन के साथ-साथ अन्य वैज्ञानिकों, अधिकारीयों, कर्मचारीयों एवं छात्रों ने अपना भरपूर सहयोग प्रदान किया |
हिन्दी सप्ताह समारोह के समापन अवसर पर मुख्य अतिथि के रूप में प्रोफेसर हरि मोहन शर्मा जी उपस्थित थे जो दिल्ली विश्वविद्यालय के हिन्दी विभाग के विभागाध्यक्ष हैं| समापन समारोह की अध्यक्षता संस्थान के निदेशक डॉ. जी. बी. नायर नें की| विजेता प्रतिभागियों को संस्थान के निदेशक नें पुरस्कार भी वितरित किए|

Pediatric Biology Centre won three Grand Challenges (India) Grant Opportunity awards


Posted on: 2015-09-17

Investigators and collaborators of the Pediatric Biology Centre won three Grand Challenges (India) Grant Opportunity awards from the Bill and Melinda Gates Foundation for the call on All children Thriving-Creating and Measuring Integrated solutions for healthy birth, growth and development. The program, managed in India through strategic partnership between BMGF-DBT and BIRAC, announced these awards during the BIRAC Innovators Meet held on 15th September 2015 at the Heritage Village, Manesar, Gurgaon.
These seed grant awards were for
1. “Creation Of A Bio Repository And Imaging Data Bank For Accelerating Evidence Generation To Facilitate Children To Thrive” to THSTI ( PBC-Dr. Shinjini Bhatnagar, Dr. Pallavi Kshetrapal, Dr. Nitya Wadhwa, Dr. Uma Chandra Mouli Natchu, Dr. Shailaja Sopory; CHME- Dr.G.B. Nair, Dr. Bhabatosh Das) along with collaborators from NIBMG ( Dr. Partha Majumder, Dr. Arindam Maitra) and RCB ( Dr. Dinakar Salunke, Dr. Tushar Maiti). The proposed project will be co-ordinated by Dr. Shinjini Bhatnagar
2. “The humble absolute neutrophil count as a measure of mucosal inflammation and as a predictor of linear growth in Indian infants” to Dr. Uma Chandra Mouli Natchu and Dr. Shailaja Sopory
3. “Stress outcomes on pregnancy, fetal growth and birth weight: Development of methods to identify mothers at risk for preterm birth and intra uterine growth restriction resulting from maternal stress” to Dr. Arindam Maitra (NIBMG), Dr. Tushar Maiti (RCB) and Dr. Nitya Wadhwa (PBC-THSTI)

THSTI observed Sadbhavana Diwas


Posted on: 2015-08-20

THSTI observed Sadbhavana Diwas

THSTI celebrates Independence Day 2015


Posted on: 2015-08-15

THSTI celebrates Independence Day 2015

Prof. Suniti Solomon, the pioneering researcher who detected first HIV case in India and a collaborator friend of THSTI passes away


Posted on: 2015-07-31

HIV researcher Dr. Suniti Solomon, who first documented to the world the prevalence of the HIV infection in India in 1986 and one who truly led research into the treatment passed away at her residence in Chennai on 28 July, 2015. One of India’s foremost HIV/AIDS researchers, Dr. Suniti Solomon was the first person to set up the voluntary testing and counseling center (VCTC) in the country. She was a pioneer in treating HIV patients since early 80s during a time when most medical practitioners were reluctant to treat HIV/AIDS patients. She founded the Y R Gaitonde Center for AIDS Research and Education (YRG CARE), a premier non-government organization set to carry out care and support center, in Chennai. She was also the Professor of Microbiology at the Madras Medical College. A pioneer in public health and HIV research, Dr. Solomon was part of several inventive HIV prevention trial research supported by agencies including the US National Institute of Mental Health, the US National Institute of Allergy and Infectious Disease. She served as the President of the AIDS Society of India. In 2012, Dr Solomon was awarded with the Lifetime Achievement Award for Service on HIV/AIDS by the MGR Medical University and in 2009; the Ministry of Science and Technology conferred her with the National Women Bio-scientist Award. The Tamil Nadu State AIDS Control Society also had given her a Lifetime Achievement Award. She was awarded a DMS (Honoris Cusa) by the Brown University in USA in 2006. In addition, for her excellent humanitarian work, she was awarded with the Mother Teresa Memorial Award for education and humanitarian services. She was a fellow of National Academy of Medical Sciences (NAMS), New Delhi and had served on several boards, including National Technical Team on Women and AIDS, Advisory Board of the International AIDS Vaccine Initiative, the Scientific Committee of the National AIDS Research Institute Pune and the Microbicide Committee of Indian Council of Medical Research.
Dr. Solomon’s contribution and support has immensely helped to bridge the challenging gap to implement one of the very important scientific agenda being carried out in the HIV Vaccine Translational Research (HVTR) laboratory at the Translational Health Sciences and Technology Institute (THSTI). The HVTR laboratory at THSTI is carrying out reverse vaccinology study (Protocol G), where investigators are assessing a large number serum samples and memory B cells obtained from anti-retroviral naïve slow progressing HIV positive individuals for presence of broadly neutralizing antibodies. This study will enable identify elite neutralizers and help isolate broadly neutralizing human monoclonal antibodies which then will help rational immungen design. Dr. Solomon’s support has helped recruit, retain, collect appropriate patient samples maintaining the highest ethical standards and are being screened at the HVTR laboratory through collaboration through the International AIDS Vaccine Initiative (IAVI). In the event, scientists at THSTI achieve the desired milestone; Dr Solomon’s contribution will be of paramount importance.

THSTI observed a two minutes silence to condole the sudden demise of Dr. APJ Abdul Kalam, former President of India at 11 am on 28th July, 2015


Posted on: 2015-07-28

THSTI observed a two minutes silence to condole the sudden demise of Dr. APJ Abdul Kalam, former President of India at 11 am on 28th July, 2015

Sphaera pharma, THSTI and Wellcome Trust collaborates


Posted on: 2015-07-23

To develop novel treatment for drug resistant tuberculosis
Sphaera Pharma (India), a subsidiary of Sphaera Pharma (Singapore), and the Drug Discovery Research Centre (DDRC) of the Translational Health Science and Technology Institute have received funding from The Wellcome Trust to develop a novel, first-in-class, therapeutic for the treatment of multiple drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB).
This is based on a unique approach, first identified at the International Centre for Genetic Engineering and Biotechnology, that targets a host protein. The approach has the potential to be more effective, and is less likely to result in development of drug-resistance. It is also expected to work in conjunction with current therapies.
Dr Sundeep Dugar, Chief Executive Officer, Sphaera Pharma Singapore, has indicated that this novel approach through the collaboration between Sphaera Pharma, India, DDRC and Wellcome Trust has the potential to deliver a first-in-class novel therapy for TB.

THSTI celebrates the 6th Foundation Day


Posted on: 2015-07-17

THSTI celebrates the 6th Foundation Day

DDRC receives Wellcome grant for TB drug discovery research


Posted on: 2015-07-14

Dr. Kanury Rao (DDRC, THSTI), in collaboration with Sphaera Pharma (India), has received funding from The Wellcome Trust to develop a novel, first-in-class, therapeutic for the treatment of multiple drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB).
This is a unique approach that targets a host protein and has the potential to be more effective, less likely to result in development of resistance and should work in conjunction with current therapies. Initial work towards this goal was done in ICGEB.
The incidence of MDR and XDR TB are on the rise and current treatments are not very effective, with long treatment regimens and significant side effects. Hence there is urgent need for the development of new anti-TB drugs that are cheaper, easily available, more effective and require a shorter treatment period. India also has one of the worlds highest burden of tuberculosis with approximately 66000 MDR-TB (Multiple Drug Resistant TB) cases among notified pulmonary TB cases in 2011.

Sakshi Malik is selected for three International Travel award


Posted on: 2015-07-10

Sakshi Malik, PhD student of Dr. Amit Awasthi at THSTI has got the international travel award to attend 6th congress of Federation of Immunological societies of Asia-Oceania at Singapore (29th June - 3rd July).
She has also been selected for International travel award by upcoming 4th European Congress of Immunology at Austria ,Vienna and EMBO meeting at Birmingham (September 6th - 9th, 2015).

Dr. Amit Awasthi has been elected as member of American Association of Immunologist, 2015


Posted on: 2015-07-10

Dr. Amit Awasthi has been elected as member of American Association of Immunologist, 2015.
Dr. Amit Awasthi has been selected to give plenary/lead talk at "Immunocon-2015" Annual Conference of Indian Immunology Society (October 9th - 11th, 2015)
Dr. Amit Awasthi has been invited as a international speaker at Academy of Immunology & Microbiology, Institute of Basic Science at Pohang University of Science & Technology (POSTECH), South Korea (October 14th, 2015).

The First Gates Foundation Grant to THSTI


Posted on: 2015-07-02

The Translational Health Science and Technology Institute (THSTI) has received its first grant from the Global Policy and Advocacy Program at the Bill Melinda Gates Foundation for creation of a "National Roadmap for targeted introduction of the available Oral Cholera Vaccine in India". The Principal Investigator for this project is Dr. G.B Nair and this roadmap created with inputs from an Expert Group on Cholera created for this purpose and will be coordinated by Dr. Sanjukta Sen Gupta from the Policy Center for Biomedical Research at the institute.
Although several companies are gearing up to produce oral cholera vaccine, ShancholTM is the only available oral cholera vaccine as of now. It is WHO prequalified and manufactured in India and has been shown to be safe and efficacious both in endemic and outbreak situations in several parts of the world. Even though ShancholTM is used through private healthcare in India it is out of reach of the marginalized population of the country that is affected by cholera. A roadmap for introduction in the national immunization program will ensure its availability to the population, which needs it the most.

The First Gates Foundation Grant to THSTI


Posted on: 2015-07-01

The Translational Health Science and Technology Institute (THSTI) has received its first grant from the Global Policy and Advocacy Program at the Bill Melinda Gates Foundation for creation of a "National Roadmap for targeted introduction of the available Oral Cholera Vaccine in India". The Principal Investigator for this project is Dr. G.B Nair and this roadmap created with inputs from an Expert Group on Cholera created for this purpose and will be coordinated by Dr. Sanjukta Sen Gupta from the Policy Center for Biomedical Research at the institute.
Although several companies are gearing up to produce oral cholera vaccine, ShancholTM is the only available oral cholera vaccine as of now. It is WHO prequalified and manufactured in India and has been shown to be safe and efficacious both in endemic and outbreak situations in several parts of the world. Even though ShancholTM is used through private healthcare in India it is out of reach of the marginalized population of the country that is affected by cholera. A roadmap for introduction in the national immunization program will ensure its availability to the population, which needs it the most.

Scientists in THSTI Develop Novel Genetic Tools to speed up Drug Discovery Research


Posted on: 2015-06-30

Genetic information of a living organism is pivotal in understanding its biology. Every single gene carries a code which defines a particular function in the cell. How exciting it would be if the genes of bacteria like the one that causes cholera and tuberculosis can be studied by turning them “on” or “off” at the will of the scientists? This is not an easy task as the disease causing bacteria are often smart and are difficult to manipulate. Scientists have to outwit them by constantly developing novel tools and techniques. Two scientists at the Translational Health Science and Technology Institute (THSTI) have independently created tools that have successfully addressed this challenge. Their research work was majorly funded by the Department of Biotechnology, Ministry of Science and Technology, Government of India.
Dr. Bhabatosh Das, Assistant Professor at the Centre for Human Microbial Ecology, THSTI, and his team have successfully built a delivery tool technically called “vector” for introducing and controlling any gene that they wish to study in a range of bacteria. The scientific intelligence involved in the building of this vector termed as pBD32 (BD is abbreviation for Bhabatosh Das) is the selection of the DNA from various sources and bringing them together into one delivery system. pBD32 has a piece of DNA termed as XBS selected from a virus which in nature was known to attack the cholera bacteria and with the help of this DNA fragment goes and sits inside the bacterial chromosome. Dr. Das believed that XBS would come handy to place any gene of interest in other bacterial chromosome to turn the gene “on” or “off”. Scientifically this is termed as a stable, broad host range tightly regulated expression system that as described by Dr. Das and his team in their Journal of Bacteriology Publication (Volume: 196, Number:23, December 2014, Pages-4071-4080) could be used in several bacteria like Vibrio cholerae (causing Cholera) and Klebsiella pneumoniae (causing Pneumonia), Salmonella enterica (causing Typhoid fever), Escherichia coli (lives in human gut).
Scientists working across the world like USA, Germany, UK, Japan are using this genetic tool for functional studies in the drug discovery field and highly appreciated the development with encouraging complements:
Victor DiRita, University of Michigan, USA: “This clever new vector will be a great value to many researchers and I am pleased we are presenting it to the field as a paper in Journal of Bacteriology”.
Dhruba Chattoraj, NIH Bethesda, USA: “You have expanded the repertoire Vc genetic toolbox by making some really useful vectors”.
Christian Berens, Institute of Molecular pathogenesis, Germany: “Thank you very much for your efforts and for providing this vector to the community”.
Robert Blumenthal, The University of Toledo College of Medicine, USA: “I read your J. Bacteriol paper with great interest, and believe that pBD62 could be very useful in my research on E. coli recombination”.
Dr. Catherine Monahan, Cubist Pharmaceuticals, Inc. USA: “The work described in your paper is very interesting, particularly the plasmid’s ability to stably integrate as a single copy into the chromosome of different bacterial species. The capability to differentially regulate the expression of a cloned gene using the pBAD promoter in various backgrounds is very exciting”.

When it comes to the tuberculosis causing bacterium Mycobacterium tuberculosis, nothing is ever enough as this bacterium has successfully made it difficult for the scientists to study its essential genes. Tuberculosis is a major global killer accounting for two deaths every three minutes killing ~ 2 million people every year. None of the tools developed till date has been proved to be greatly efficient in elucidating essential gene function in TB. Turning “off” the essential genes is a primary approach but is a major challenge as most of the delivery tools do not achieve finding the exact place where the essential gene sits in the mycobacterial genome and do not have efficient blocking mechanism for causing loss of function. Dr. Nisheeth Agarwal, Assistant Professor at the Vaccine and Infectious Disease Research Center, THSTI, and his team have tackled it by improvising the CRISPRi (Clustered Regularly Interspaced Short Palindromic Repeat Interference) tool for disrupting the mycobacterial genes in a cost effective manner. This tool employs a foreign protein dCas9 borrowed from other bacteria and tweaked by his team to work in mycobacteria, and a stretch of oligonucleotide fragment termed as guide RNA (sgRNA) designed to pair with the gene in the mycobacteria that the scientist would like to disrupt. Dr. Agarwal’s team has successfully engineered specific guide RNAs-dCas9 complex for many essential genes of the mycobacteria and have disrupted them from becoming functional. This tool is simple, cost effective and more importantly quicker considering that the tuberculosis causing mycobacteria takes a long time to culture under laboratory conditions and precious time is lost in the absence of quick manipulative tools. More than 50 genes could be inactivated in a short span of six months using this tool in Dr. Agarwal’s laboratory. This will enable identifying new pathways unique to M. tuberculosis growth and design drugs against it in a significantly greater pace. The study was published in Nature Communications on 25th February, 2015 and has received worldwide acclaim from the community of eminent TB researchers:
Dr. Jeff Cox, University of California San Francisco: “it represents an exciting advance for the field”.
Dr. Jiayun Liu, Johns Hopkins University: “I admire you very much for your great achievement in this field”.
Dr. Dirk Schnappinger, Weill Cornell Institute: “Congratulations on your recent paper in Nature communications. Very nice work”.
Dr. Sarah Stanley, University of California, Berkeley: “Congratulations on this excellent publication of a breakthrough technology for those of us in the M. tuberculosis field.

World enviroment Day 2015 plantations at THSTI


Posted on: 2015-06-24

World enviroment Day 2015 plantations at THSTI

Launch of celiac disease diagnostic kit


Posted on: 2014-10-30

A diagnostic kit for celiac disease developed jointly by THSTI, ICGEB & AIIMS sponsored by DBT, has been launched by the Honble Science and Technology minister Dr. Jitendra Singh in a ceremony on 28th Oct. Please find the press release of the program.
download/Business_standard_CD.pdf
downloads/Down_to_earth_CD.pdf
downloads/hindustan_times.pdf

Cleanliness drive at THSTI


Posted on: 2014-10-02

THSTI observed "Swachhta Divas" on 2nd October, 2014.

संस्थान में हिन्दी सप्ताह समारोह का आयोजन 2014


Posted on: 2014-09-26

प्रत्येक वर्ष की भाँति संस्थान में इस वर्ष भी हिन्दी सप्ताह समारोह 22 से 26 सितम्बर 2014 के मध्य आयोजित किया गया| सप्ताह के प्रथम दो दिवसों में सभी वैज्ञानिकों, अधिकारियों, कर्मचारियों एवं छात्रों को केवल हिन्दी में बात करने तथा अपना वैभागिक कार्य हिन्दी में करने के लिए प्रेरित किया गया|
सप्ताह का औपचारिक उद्घाटन संस्थान के कार्यकारी निदेशक डाँ. जी. बी. नायर नें किया| इस पावन अवसर पर संस्थान के अधिष्ठाता (अकादमी ) एवं अधिष्ठाता (नैदानिक शोध) के साथ अन्य वरिष्ठ वैज्ञानिक, अधिकारी, कर्मचारी एवं छात्र उपस्थित थे|
समारोह के मध्य पूरे सप्ताह भर विभिन्न हिन्दी कार्यक्रम आयोजित किए गये जैसे निबंध लेखन प्रतियोगिता, हिन्दी वर्तनी (स्पेलिंग), हिन्दी प्रश्नोत्तरी तथा अनुलोम- विलोम शब्द, किसी तात्कालिक दिए गये विषय पर हिन्दी में अपने विचार व्यक्त करना, स्वयं द्वारा रचित हिन्दी कविता पाठन इत्यादि|
हिन्दी सप्ताह समारोह के समापन के अवसर पर मुख्य अतिथि के रूप में प्रोफेसर गोविंद प्रसाद जी उपस्थित थे जो जवाहर लाल नेहरू विश्वविद्यालय के हिन्दी विभाग के विभागाध्यक्ष हैं| समापन समारोह की अध्यक्षता संस्थान के कार्यकारी निदेशक डॉ. जी. बी. नायर नें की| विजेता प्रतिभागियों को मुख्य अतिथि नें पुरस्कार भी वितरित किए|

THSTI in the media for its Inter-institutional Program on Maternal Neonatal and Infant Sciences


Posted on: 2014-09-05

The minister of Science and Technology, Govt. of India, has recently made a press briefing about a major initiative of Department of Biotechnology, the Inter-institutional Program on Maternal Neonatal and Infant Sciences. THSTI, being a major contributor to the program with Dr. Shinjini Bhatnagar leading the multi-institutional and multi-disciplinary group, received a special mention in the press release. Read the press articles here:


http://indianexpress.com/article/cities/delhi/govt-plans-study-on-preterm-births-to-prevent-neonatal-deaths/

http://articles.economictimes.indiatimes.com/2014-09-02/news/53480123_1_preterm-babies-india-institute-preterm-birth

http://www.deccanherald.com/content/429047/joint-study-preterm-birth-launched.html

THSTI celebrates the 5th Foundation Day


Posted on: 2014-08-08

THSTI celebrated its 5th Foundation Day on July 15th. The occasion was celebrated with grand enthusiasm by the THSTI community along with our donors, collaborators and well wishers. The Foundation Day pre-ceremony was marked by poster competition by students/fellows from research organizations of Delhi-NCR, quiz and debate by THSTI students, faculty and administrative personnel.

The evening started with the presentation of a report on THSTI by our Executive Director, Prof. G.B.nair.

Keynote address was given by Secretary DBT, Prof K. Vijayraghavan. DBT perspective on THSTI was shared by Dr. T.S. Rao (Senior Advisor, DBT). Prof. M.K.Bhan presented the perspectives of our Scientific Advisory Group of Experts (SAGE). Dr. T.S. Balganesh, Distinguished Scientist, OSDD-CSIR, delivered the Foundation Day oration.

Better understanding of Cholera Outbreaks - a prerequisite to prevent them


Posted on: 2014-08-07

Dr. G. Balakrish Nair, Executive Director, THSTI and Dr. Yoshifumi Takeda, Kyoto University, Japan has recently published Cholera Outbreaks in electronic and print format with Springers. This book provides a better understanding of cholera outbreaks. The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks, and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oral cholera vaccines to stop the spread of cholera outbreaks.
http://www.springer.com/biomed/medical+microbiology/book/978-3-642-55403-2

Introduction of e-Procurement module at THSTI by Dr. T.S. Rao


Posted on: 2014-07-07

In consonance with the directives received from the Department of Biotechnology (DBT), THSTI has started publishing their tenders through e-Procurement module of CPP portal. A formal function was held on 7th July, 2014 for the introduction of e-Procurement module at THSTI for which Dr. T.S. Rao, Senior Adviser, DBT was the chief guest.
Dr. G. B. Nair, Executive Director, THSTI welcomed the gathering and explained the need for e-Procurement in government organisations. He stated that e-procurement not only makes the system transparent and efficient, it also instils confidence among the vendors in the tendering system. Dr. T.S. Rao clarified that the government of India is monitoring the progress of the National e-governance plan (NeGP) and stated that e-Procurement is an important module under its mission mode project. He congratulated Mr. M.V. Santo, Head-Administration and his team for this achievement of introducing e-Procurement in THSTI.
Dr. T.S. Rao clicked the publish tender button under the e-Procurement module of CPP Portal to publish a tender for the purchase of an Ultrasound Machine for the Paediatric Biology Centre of THSTI.
downloads/eprocurement-introduction.pdf

Dr. Guruprasad Medigeshi receives the Wellcome Intermediate Fellowship


Posted on: 2014-06-20

Dr. Guruprasad Medigeshi, an Assistant Professor at the Vaccine and Infectious Disease Research Centre, THSTI, has received the Intermediate Fellowship by Wellcome-DBT India Alliance. His research proposal attempts to understand the dynamics of zinc influx and efflux mediated by zinc transporter proteins during viral infections and to assess if changes in zinc homeostasis has any bearing on the pathogenesis and disease outcome. Majority of childhood infections have viral etiology and pediatric illnesses caused by viruses such as dengue, respiratory syncytial virus and rotavirus are leading cause of child mortality worldwide. A number of clinical trials have been conducted with zinc supplementation as an adjunct in the treatment of some of these infections with conflicting results. There is a need to understand the mechanism of interaction between viral infections and zinc homeostasis in order to develop better therapeutic supplementation strategies using zinc. Dr. Medigeshis research is expected to bring great insights into this field.

Dr. Jayanta Bhattacharya receives National Bioscience Award


Posted on: 2014-06-20

Dr. Jayanta Bhattacharya received the prestigious National Bioscience Award by Department of Biotechnology this year. He is a Principal Scientist II (Research and Development) at the International AIDS Vaccine Initiative, India. As a Principal Investigator at the HIV Vaccine Translational Research Laboratory (HVTR), Gurgaon, a collaborative endeavor of the Translational Health Science & Technology Institute and International AIDS Vaccine Initiative, he is working on discovery of novel broad and potent antibodies from Indian patients using reverse vaccinology.

Maastricht University Medical Centre Delegates visit


Posted on: 2014-03-31

The Dutch Delegates including Jos Smits, Director Centre for Research Innovation, Support and Policy (CRISP), Dean for Research of FHML at Maastricht University, Professor of Pharmacology, Dorine Collijn , Head of Research Policy Department (CRISP), Shyam Vasudevarao , Technical Director Faculty of Health, Medicine and Life Sciences , Maastricht University visited THSTI to strengthen IndoDutch collaboration and initiate research programs with THSTI investigators. An overview of their strengths and existing activities was presented by Jos Smits. The Delegates had shown particular interest in the following activities at TSHTI: The Centre for Biodesign, the Centre for Human and Microbial Ecology and the Policy Centre for Biomedical Research. Faculty and Scientists of THSTI also actively participated during the discussion about the future prospects of collaboration between MUMC and THSTI. Discussion ended with a positive note for finding grounds of collaborative work to be carried out between the two institutes.

Symposium on Probiotics, Microbiome and Gut function Transforming Health and Well-being


Posted on: 2014-03-11

Yakult India Microbiota and Probiotic Science Foundation in association with the Translational Health Science and Technology Institute, Gurgaon and Apollo Hospitals organized the probiotic symposium , Probiotics, Microbiome and Gut function Transforming Health and Well-being on 15th and 16th February 2014 at the Intercontinental Eros Hotel, Nehru Place, New Delhi, India.
The programme of the symposium was especially designed to unravel the factors that shape the microbial communities of the gut and identify the latest developments in probiotic science that will positively affect the microbiota for clinical intervention. Keynote lectures by leading International and national experts allowed a better understanding of the matrix for probiotic delivery , mechanism of action of probiotics, the role of probiotics in preventing infections and an insight into the Alimentary Pharmabiotic Centre that serves as a model of how scientists, clinicians and industry can work together with shared goals. An insight into the epidemiological studies conducted on probiotics and the integration of probiotics in day to day clinical and nutritional practice were also some exciting highlights of the symposium.
This symposium brought together International and National experts and captured the latest findings on the growing science of the Gut Microbiota and the role of Probiotics for improvement of health and well-being.
Welcome address speech were delivered by Prof N. K. Ganguly, Distinguished Biotechnology Research Professor, Department of Biotechnology, Ministry of Science and Technology, Government of India, Prof. G. Balakrish Nair, Executive Director, Translational Health Science Technology and Institute and Prof. Anupam Sibal, Group Medical Director and Senior Consultant Pediatric Gastroenterologist and Hepatologist, Apollo Hospitals. During the symposium Prof. Yoshifumi Takeda, Emeritus Member, National Institute of Infectious Disease, Toyama, Shinjyuku, Japan was honored with Lifetime Achievement Honour award.
Recognizing the need to promote probiotic research in the country, the Foundation instituted three young Investigator awards to felicitate talent and knowledge.
http://yimpsf.in/webcast.html

THSTI HIV Vaccine Initiative in News


Posted on: 2014-03-06

Researchers at HIV Vaccine Translational Research Laboratory in India are close to isolating neutralising antibodies from HIV-infected individuals who have been infected but have not developed any disease for years. The HIV Vaccine Translational Research Laboratory is a research facility at the Government of Indias Translational Health Science and Technology Institute (THSTI) in the National Capital Region of New Delhi, India. The laboratory is a joint venture of IAVI and THSTI. The mission of the Laboratory is to develop strategies to accelerate the design and evaluation of HIV immunogensthe active ingredients of vaccinesin preclinical studies. Its ultimate aim is to design vaccines to prevent HIV infection, particularly vaccines that elicit an immune response capable of neutralizing a broad spectrum of HIV variants. The Laboratorys operations are coordinated with those of IAVIs AIDS Vaccine Design and Development Laboratory in New York, which coordinates all IAVI-supported vaccine design efforts, and the IAVI Neutralizing Antibody Center at The Scripps Research Institute in California, which serves as the headquarters of the Neutralizing Antibody Consortium (NAC). Follow the link to read the article in News:
http://www.thehindubusinessline.com/economy/indian-researchers-get-leads-on-hiv-vaccine/article5753963.ece

THSTI felicitates Prof. Mathuram Santosham for receiving Albert B. Sabin Gold Medal


Posted on: 2014-02-10

THSTI felicitated Prof Mathuram Santosham for receiving the prestigious Albert B.Sabin Gold Medal. The felicitation was done by THSTI Executive Director Dr. GB Nair in presence of all the faculty, scientists and scholars of THSTI.

Prof. Mathuram Santosham, M.D., is a professor of Pediatrics and Pediatric Infectious Diseases at Johns Hopkins, and director of both its Health Systems Program and Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health. He is a renowned expert in oral rehydration therapy and has conducted numerous clinical trials in the U.S. and worldwide on the safety and efficacy of oral rehydration therapy and gastroenteritis.

Albert Sabin Gold Medal is the highest scientific honor given by the Sabin Vaccine Institute and commemorates the legacy of the late Dr. Albert B. Sabin. This prestigious award is presented by the Sabin Vaccine Institute (Sabin) as part of the National Foundation for Infectious Diseases (NFID) annual conference.

Dr. Shinjini Bhatnagar Professor and Dean (Clinical Research) was also requested to speak a few words and she congratulated Prof Mathuram Santosham on receiving the award and expressed her happiness.

It was delightful to hear Prof Santosham sharing his journey of a scientific career in the most humble way and also thanking THSTI for felicitating him.

Erasmus University Medical Centre Delegates visit THSTI


Posted on: 2014-02-10

The Dutch Delegates from the Erasmus University Medical Centre visited THSTI to strengthen ties with IndoDutch collaboration and also to initiate collaborative work with THSTI.

Dr. Nair, Executive Director THSTI and Dr. Shinjini Bhatnagar Professor and Dean (Clinical Research) highlighted about the research activities taking place at THSTI and also talked about possible ground of collaborations.

The Delegates who visited THSTI were Prof Gabriel Paul Krestin, Professor and Chairman Radiology Department , University Medical Center Rotterdam , Prof. Hans vander Steen , Program Director, Neuroscience, Dr M.Arfan Ikram Associate Professor , Department of Epidemiology, Radiology and Neurology , Mr J.W. (Jelle) Nijdam Counsellor, Head of Science and Technology Department, Embassy of the Kingdom of the Netherlands, New Delhi and Ms Akansha Sharma , Policy Officer, Science and Technology, Embassy of the Kingdom of Netherlands, New Delhi.

There were discussions about collaboration between the two Institutions. Prof. Krestin and Prof. Steen showed keen interest in following up for future collaborative research activities between UMCR and THSTI. Faculty and Scientists of THSTI also participated during the discussions.

Dr. Guruprasad Medigeshi receives the Wellcome Intermediate Fellowship


Posted on: 2014-02-10

Dr. Guruprasad Medigeshi, an Assistant Professor at the Vaccine and Infectious Disease Research Centre, THSTI, has received the Intermediate Fellowship by Wellcome-DBT India Alliance. His research proposal attempts to understand the dynamics of zinc influx and efflux mediated by zinc transporter proteins during viral infections and to assess if changes in zinc homeostasis has any bearing on the pathogenesis and disease outcome. Majority of childhood infections have viral etiology and pediatric illnesses caused by viruses such as dengue, respiratory syncytial virus and rotavirus are leading cause of child mortality worldwide. A number of clinical trials have been conducted with zinc supplementation as an adjunct in the treatment of some of these infections with conflicting results. There is a need to understand the mechanism of interaction between viral infections and zinc homeostasis in order to develop better therapeutic supplementation strategies using zinc. Dr. Medigeshis research is expected to bring great insights into this field.

THSTI's translational journey boosted with the Pre-Term Birth Program


Posted on: 2014-01-22

THSTI's journey on the translational road-map got a significant boost with the initiation of the program on pre-term birth, which is the first inter-institutional program on maternal-fetal-infant health in India funded by DBT under the Grand Challenge Program. It is a multi-institutional & multidisciplinary research effort to predict & diagnose Preterm Birth (PTB) by elucidating the biology of maternal-fetal-neonatal physiology. The research outputs are expected to define biological, clinical and epidemiological risk factors to achieve appropriate risk stratification of mothers at risk of premature delivery. The program also has an in-built component of providing leads for novel interventions and their implementation in population. This program has important public health implications for our country where 3.6 million are born preterm, and over 300,000 of them die each year. India, contributes to the highest number of PTB and deaths worldwide, specifically 25% of the overall global preterm related deaths. Despite the introduction of many new therapies for prevention of PTB, the problem persists. These babies who are born early are more susceptible to infections, have higher mortality and have substantial long-term problems in their late childhood and adult life. The inter-institutional and multi disciplinary profile of the programme is evident as it involves clinicians, epidemiologists and biologists from the three autonomous DBT institutes, the Paediatric Biology Centre (PBC), and the Centre for Human Microbial Ecology (CHME) at the Translational Health Science and Technology Institute (THSTI), the Regional Centre for Biotechnology (RCB), and the National Institute of Biomedical Genomics (NIBMG). The other important partners are the clinicians at the General Hospital Gurgaon and Safdarjung Hospital. The physicians from Maulana Azad Medical College and All India Institute of Medical Sceinces are co-investigators in the program. Pediatric Biology Center, is the main coordinator of the programme and the project management will be implemented by the Clinical Development Services Agency, an extramural unit of THSTI.
http://dbtindia.nic.in/docs/pre-term_birth.pdf

Signing of MoU for establishment of Population Science Partnership Centre


Posted on: 2014-01-03

THSTI has entered into a collaboration with Centre for Health Research and Development, Society for Applied Studies (CHRD-SAS - a not for profit Scientific and Industrial Research Organization, dedicated to community health research). A MoU effecting the collaboration was signed at THSTI by Dr. Nita Bhandari (CHRD SAS) and Dr. G.B. Nair (THSTI). Under this collaboration the two institutions will pursue collaborative research and innovation in population based science, focused on development, evaluation and diffusion of affordable technologies and solutions for improved health and nutrition. The collaboration will emphasize solutions and technologies of public health importance to India and to the poorest. And also promote utilization of under-used existing technologies through appropriate modification and evaluation work in partnership for translational research and permit their respective scientists to collaborate on scientific projects. The collaboration is in synergy with the objectives of THSTI.

Dr. Amit Awasthi wins Innovative Young Biotechnologist Award


Posted on: 2013-12-18

Dr. Amit Awasthi, Assistant Professor at THSTI, has received the Innovative Young Biotechnologist award from the Department of Biotechnology. This coveted award is given to nurture outstanding young scientists with innovative ideas and desirous of pursuing research in frontier areas of biotechnology. Dr. Amit Awasthi is an immunologist with research focus on discovering underlying mechanisms of Inflammatory Bowel Disease (IBD). His major thrust area of research at the Centre for Human Microbial Ecology, THSTI is to understand the regulations of effector and regulatory T cells in IBD, especially, how IL-27 regulates Th17 cell response and enhances Tregs functions in gut inflammation. His research aims to open new avenues for development of therapeutic strategies in IBD.

JNU-THSTI MoU


Posted on: 2013-10-14

In June 2013, Jawaharlal Nehru University (JNU) accorded recognition to the THSTI academic program leading to the award of the PhD degree. An MoU to this effect was signed on 30th September 2013 on behalf of the two institutions by Prof. S. K. Sopory, Vice-Chancellor, JNU and Dr. G. B. Nair, Executive Director, THSTI at the JNU campus in New Delhi. The MoU provides for the enrollment of THSTI research students at JNU for their PhD degree. It extends to collaborative use of scientific expertise and infrastructure between the two institutions and also to the participation of THSTI faculty in the proposed integrated M.Sc.-Ph.D. course at the Special Center for Molecular Medicine, JNU.

संस्थान में हिन्दी सप्ताह समारोह का आयोजन
THSTI Celebrates Hindi Saptah


Posted on: 2013-09-13

In keeping with the national language objectives, THSTI commenced the HINDI SAPTAH celebrations from 16th September 2013. The week long celebrations were rolled out by Rashtrabhashashri and eminent scientist, Prof. Durga Dutt Ozha. The leadership at THSTI urged the members of the Institute to proactively adopt the Hindi language as it is the only medium in which they could interact with the beneficiaries of their Translational Research. As a part of the celebrations, 25 THSTIans participated in an spot essay competition in Hindi. The topic TV/Computer ke prabhav aur dushprabhav was selected by Prof. Ozha . The winners of the completion are:
First Prize: Mr. Ekalvya Srivastava
Second Prize: Mrs. Bhavya Khullar
Third Prize: Ms. Aakriti Upadhyay

THSTI celebrates the Fourth Foundation Day.


Posted on: 2013-07-18

The Institute celebrated its traditional Foundation Day on12th July 2013. THSTI's Foundation Day Address was made by Dr. Rita Colwell, former Director, US National Science Foundation. Dr. M.K. Bhan, Distinguished Professor, Ministry of Science and Technology, GoI, delivered the Keynote address. The Chairman's address was delivered by Prof. K VijayRaghav, Secretary, Department of Biotechnology, Government of India. Dr GB Nair, Executive Director, THSTI, highlighted the milestones achieved in fulfilling the Institute's mandate, since inception.
downloads/thsti_PressRelease.pdf

MoU of Collaboration.


Posted on: 2013-07-09

THSTI has entered into a collaboration with the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) . A MoU effecting the collaboration was signed at Dhaka, by Dr. John Clemens (icddr,b) and Dr. G.B. Nair (THSTI) on 3rd July 2013. Under this collaborations the two institutions will permit their respective scientists to collaborate on scientific projects. Icddr,b, has a mission to develop and promote realistic solutions to major health, population and nutritional problems facing the poor people of Bangladesh and other settings. The collaboration is in synergy with the objectives of THSTI.
http://www.icddrb.org/media-centre/news/4138-icddrb-expands-south-south-collaboration-in-translational-research

JNU Recognizes Doctoral Program at THSTI.


Posted on: 2013-06-17

The Executive Council of the prestigious Jawaharlal Nehru University (JNU), recently accorded recognition to the THSTI doctoral program leading to the award of the Ph.D degree. The recognition comes within the purview of Clause 5(13) of the JNU Act. It opens another avenue for registration with a acclaimed university, for research fellows pursuing their doctoral studies at THSTI."
http://thsti.res.in/pdf/ordinances.pdf

Indo-Finnish Diagnostic Research Centre (IFDRC)


Posted on: 2013-06-06

The goal of the Indo-Finnish Diagnostic Research Centre (IFDRC) is to complement and enhance the research capabilities of its Indian and Finnish scientific networks from academia and industry in the area of diagnostics. This collaborative effort between India and Finland is set to enable innovation and facilitate collaboration in diagnostic research and development between academic and industrial players in both countries. The two countries, through Translational Health Science and Technology Institute (THSTI) under Indian Ministry of Science and Technology and University of Turku, Turku, Finland have agreed that the center has two locations: one at THSTI, Delhi and one at the University of Turku."
http://www.utu.fi/en/news/news/Pages/diagnostics-will-be-developed-by-indo-finnish-collaboration.aspx

In the Press


Posted on: 2013-05-16

Ongoing research on Rotavirus at the VIDRC, THSTI received mention in a Press Release by DBT recently. It recognizes the contribution of the Rotavirus Laboratory, led by Dr. Sudhanshu Vrati, in the development of the ROTAVAC vaccine through social innovation partnerships. The vaccine when released will be useful in the control of diarrhea, afflicting infants. The vaccine is a more affordable alternative to existing Rotavirus vaccines . It could be a boon to child care in low resource countries".
http://pib.nic.in/newsite/erelease.aspx?relid=95976

C-TRIUMPH, Dr. Nisheeth Agarwal, Assistant Professor at THSTI is now a member of a team of 39 eminent TB researchers.


Posted on: 2013-05-03

Dr. Nisheeth Agarwal, Assistant Professor at THSTI is now a member of a team of 39 eminent TB researchers from USA and India on a prestigious grant, INDO-U.S. Vaccine Action Program (VAP), on tuberculosis research. The award was announced on 10th April, 2013 The program aims to establish Cohort Research Units (CRUs) involving clinical sites, and TB research laboratories to address fundamental research using clinical samples. The project led by Dr. Soumya Swaminathan, National Institute of Research in Tuberculosis, Chennai, India and Dr. Amita Gupta, Johns Hopkins University, Baltimore, USA. They intend to establish a fully developed CRU (fCRU), titled C-TRIUMPH - Cohort for TB Research Indo-US Medical PartnersHip in India. C-TRIUMPH is a collaborative consortium, with five year tenure. Eight premier institutions in India and USA form the consortium. Its objectives are to investigate various host and microbial factors associated with progression of TB through different stages. Dr. Agarwal will study signatures of latency and active tuberculosis in the Indian population. He will co-chair the Biomarkers and Diagnostics Scientific Working Group (SWG), one of the five SWGs proposed in the fCRU. India with 40% of its population exposed to Mycobacterium tuberculosis, has two million people developing the active TB disease annually. In India, TB accounts for 26% of the worlds burden for the disease. The C-TRIUMPH project conforms to the international roadmap for tuberculosis research. The project is jointly funded by Government Departments in USA and India. Dr. Agarwal did his M.Sc in Biotechnology from Banaras Hindu University and Ph.D. in Biochemistry from the University of Delhi. He went on to do his postdoctoral fellowship from the Centre for Tuberculosis Research at the Johns Hopkins University in Baltimore, USA. He took up appointment at THSTI as assistant professor in 2010. His laboratory currently works on essential signaling molecules of M. tuberculosis and their role in growth and virulence of the pathogen.

Dr. S. K. Biswas,THSTI-National Chair


Posted on: 2013-04-29

The THSTI fraternity mourned the untimely and sudden death of Prof. Sanjay Biswas, at a condolence meeting in his memory at THSTI on April 29, 2013. Prof. Biswas was a member of the Governing Body of THSTI. His vast experience in the field of engineering and capability to bond with people was evident from the discussions during the meetings. Prof. Biswas had recently, taken over as a National Chair at THSTI. True to his character he, rapidly embarked on a very ambitious project of planning biodesign and bioengineering laboratories at Center for Biodesign. Prof. Biswas was one of the cardinal members of the strategic team articulating the vision for the National Biodesign Alliance, anchored by THSTI. He had an infectious, childlike enthusiasm, but was meticulous in carefully charting the last detail of projects he undertook. His years of experience and knowledge were brought to bear in all endeavors. He was very quietly confident that he would be able to attract the best of talent globally to create a world-class center for Biodesign and bioengineering at THSTI. We extend our heartfelt condolences to the bereaved family, colleagues and admirers of Prof. Biswas at this hour of grief. The void left by the demise of Prof. Biswas, will take a long time to fill, if at all.

Declaration Launch: 400 Experts United Against Polio


Posted on: 2013-04-12

Declaration Launch: 400 Experts United Against Polio
http://vaccines.emory.edu/poliodeclaration/index.html

THSTI HIV Vaccine Initiative in News


Posted on: 2013-03-06

Researchers at HIV Vaccine Translational Research Laboratory in India are close to isolating neutralising antibodies from HIV-infected individuals who have been infected but have not developed any disease for years. The HIV Vaccine Translational Research Laboratory is a research facility at the Government of Indias Translational Health Science and Technology Institute (THSTI) in the National Capital Region of New Delhi, India. The laboratory is a joint venture of IAVI and THSTI. The mission of the Laboratory is to develop strategies to accelerate the design and evaluation of HIV immunogensthe active ingredients of vaccinesin preclinical studies. Its ultimate aim is to design vaccines to prevent HIV infection, particularly vaccines that elicit an immune response capable of neutralizing a broad spectrum of HIV variants. The Laboratorys operations are coordinated with those of IAVIs AIDS Vaccine Design and Development Laboratory in New York, which coordinates all IAVI-supported vaccine design efforts, and the IAVI Neutralizing Antibody Center at The Scripps Research Institute in California, which serves as the headquarters of the Neutralizing Antibody Consortium (NAC). Follow the link to read the article in News:
http://www.thehindubusinessline.com/economy/indian-researchers-get-leads-on-hiv-vaccine/article5753963.ece

Delegation from Vietnam to discuss possible areas of collaboration


Posted on: 2012-09-13

The Department of Biotechnology, Govt. of India and Ministry of Science and Technology, Govt. of Socialist Republic of Vietnam has singed a Programme of Cooperation in the area of biotechnology. In this connection, a four member delegation led by Dr. Dao Ngoc Chien, Deputy Director General of High Tech Department of MoST, Govt. of Socialist Republic of Vietnam visited on 12th September THSTI to discuss possible areas of collaboration.

India Launches a New Lab for HIV Research


Posted on: 2012-08-17

NEW DELHIOn Monday, India opened a $12 million, government-backed laboratory whose mission is to create a new vaccine against HIV. The HIV Vaccine Translational Research Laboratory, which aims to recruit about 30 scientists, is embedded within the Translational Health Science and Technology Institute, a $200 million facility under development on the outskirts of New Delhi. It will work in collaboration with the New York based-International AIDS Vaccine Initiative (IAVI); operating costs will be shared equally. India has the world's third largest burden of AIDS, despite the fact that "HIV infections have declined by 56% during the last decade, from 270,000 in 2000 to 120,000 in 2009," says India's health minister Ghulam Nabi Azad. He says there is a desperate need for a vaccine against HIV. "Designing a new broad-spectrum HIV vaccine will be the mandate of this new lab," says Margaret G. McGlynn, CEO of IAVI. The goal is achievable, she says: "Researchers have long known that after a few years of infection, a minority of HIV-positive people produce antibodies that can neutralize a broad spectrum of HIV variants." The aim is to find a suitable broad spectrum antibody for the purpose. McGlynn says the plan is to make and test a vaccine in India, which she says is "suitably placed with its talented scientific manpower, well-established pharma industry, and a huge commitment from the government."
http://news.sciencemag.org/2012/08/india-launches-new-lab-hiv-research

Dr. Amit Awasthi, Selected for National Academy of Science of India.


Posted on: 2012-07-26

Dr Amit Awasthi, Asst Professor, THSTI, has been selected for the National Academy of Sciences of India - Young Scientist Platinum Jubilee Award 2012 in the field of Bio-medical, Molecular Biology and Bio-technology.

Appointment of Executive Director for THSTI.


Posted on: 2011-10-20

Dr. G.B. Nair has been posted as the Executive Director of Translational Health Science and Technology Institute, Faridabad, which is an autonomous institute of Department of Biotechnology under Ministry of Science and Technology, Govt. of India. Dr Nair is an internationally renowned Scientist who has done extensive research in the field of Diarrheal Diseases particularly on cholera. He has many publications and patents to his credit. Dr. G.B. Nair was earlier the Director of National Institute of Cholera and Enteric Diseases (NICED), Kolkata. He has held various other postings in India and abroad including that of the Director of the Laboratory Sciences Division in the International Centre for Diarrhoeal Diseases Research, Bangladesh.

G.N. Ramachandran Gold Medal for Excellence in Biological Science & Technology to Dr. Dinakar M. Salunke.


Posted on: 2011-09-13

Gold Medal for excellence in Biological Sciences & Technology Instituted by the Council of Scientific & Industrial Research (CSIR) in the memory of Prof G N Ramachandran, has been announced for the year 2010 to Dr. Dinakar M Salunke. Dr Salunke has been awarded this medal for his outstanding contributions in understanding of the generation of antibody diversity and the processes by which antibodies change shape for interactions with antigens.